胸腺肽α1治疗重症肝炎的免疫调节研究

黄自存; 杨健; 周建良; 齐晖; 黄瑞芳; 戴勇

胸腺肽α1治疗重症肝炎的免疫调节研究

详细信息

中图分类号: R512.6
计量
- 文章访问数: 2502
- HTML全文浏览量: 15
- PDF下载量: 20
- 被引次数: 0
出版历程
- 出版日期: 2000-02-20

Immune regulation of Thymosin α1 was studied in severe hepatitis

摘要

摘要: 为了解日达仙的免疫调节作用 ,选取 18例重症肝炎病人用日达仙（Tα1）治疗 ,并在治疗前后检测内毒素（LSP）、肿瘤坏死因子（TNF）、白细胞介素 2受体（IL - 2R）、白细胞介素 4（IL - 4）、白细胞介素 6 （IL - 6 ）、及T细胞亚群（CD+ 8CD+ 4）。结果治疗前LSP、TNF、IL - 2R、IL - 6、CD+ 8均增高（P <0 0 1） ,而IL - 4及CD+ 4降低。经Tα1治疗后LSP、TNF、IL - 2R、IL - 6、CD+ 8均降低（P <0 0 1） ,而IL - 4和CD+ 4增高。提示Tα1是一种强有力的免疫调节剂 ,它能降低LSP、TNF、IL - 2R、IL - 6、CD+ 8,提升IL - 4水平 ,从而减轻重症肝炎时免疫反应对肝细胞的损伤
- 日达仙 /
- 重症肝炎 /
- T细胞亚群 /
- 炎症性细胞因子
Abstract: WT5”BZ]To study immune regulation of Tymosion α 1 (Tα 1) Eighteen patients with severe hepatitis were treated by Tα 1 The levels of LSP, TNF, IL-2R, IL-4, IL-6, CD + 8CD + 4 in the serum were observed before and after Tα 1 therapy Before treatment, the levels of LSP, TNF, IL-2R, IL-6, and CD + 8 increased, and levels of IL-4, and CD + 4 decreased in the patients At the end of treatment, the levels of LSP, TNF, IL-2R, IL-6 and CD + 8 decreased, and levels of IL-4 and CD + 4 increased The studies showed Tα 1 is an immune regulation It can reduce immune damage of liver-cells in severe hepatitis [WT5”HZ]
- WT5”BZ]Thymosion severe hepatitis Immune regulation /

HTML全文

参考文献(7)

〔1〕AndoKTakashiMoriyamaLucaGguidottietal MachanismsofClassⅠRestrictedImmunopathologyATransgenicMouseModelofFulminantHepati tisJExpMed , 1993 , 78∶15 41

〔2〕黄自存 , 张国良 , 周大 , 等胸腺肽α1 联合干扰素α1 b治疗慢性病毒性乙、丙型肝炎中国新药杂志 , 1997, 2∶90

〔3〕BaumannCABadamchianMGoldsteinAl ( 195 5 ) Tα1 antagonizesinducedapoplosisofdevelopingthymocytesinvitroMolCellBiol啨ｓ毢啨ａ (abstract2 0 72 )

〔4〕SekiyamaKDyoshibaMThomsonAWetal Circulatingproinflammatorycytokines (IL -1pTNFαandIL -6) andIL -1receptorantagonist (IL -ΙRa) infulminantHepaticfailureClinExpImmunol 1994。 98∶71

〔5〕FrancescoPDGaziano -RCombinedeffectoffluconasoleandthymosincα1 onsystemiccandidasisinmiceImmunopressedbymorphineTreatmentsClinExpImmunol 1994。paper 42 6

〔6〕FukudaRIshimuraNNguyenTXetal TheexpressionofIL -2IL -4andInterferongam (IFNr) mRNAUsingliver, biopsisatdifferentphaseofa cutexacerbationofChronicHepatitisBClinExpImmunol1995。 10 0∶446

[]〔7〕裕石明 , 张立煌 , 方梅林。等 IL -4对重症肝炎患者外周血单核细胞IL -1α表达调节研究 , 中华传染病杂志 , 1998, 16 ( 3 ) ∶14 4

施引文献

资源附件(0)

访问统计