PDF下载 ( 80 KB)
The effect of insulin resistance and secreting functions on glucose metabolism of patients with Cirrhosis.
-
摘要: 为探讨肝硬化患者胰岛素抵抗及胰岛素分泌功能和糖代谢的改变。对 30例肝硬化患者和 2 6例正常人进行口服葡萄糖耐量及胰岛素释放试验 ,以Homa模型计算胰岛素抵抗指数 (IR)及胰岛 β细胞功能指数 (HB CI) ,并对结果进行分析。结果显示 ,肝硬化组糖耐量较对照组显著降低 (P <0 0 1) ,血清胰岛素水平增高 ,并呈现释放延迟 ,IR及HBCI指数高于对照组。结论 :肝硬化患者存在胰岛素抵抗、肝源性糖耐量异常及内源性高胰岛素血症或胰岛素释放延迟 ,与肝功能损害有关。Abstract: WT5”BZ] To evaluate the effect of Insulin resistance and secreting function on glucose metabolism of patients with cirrhosis, 30 cirrhosis patients and 26 controls were enrolled in the OGTT and insulin releasing test.IR derived from Homa model and HBCI were used for result analysis. Significant reduction in OGTT was observed while a rise in IR and HBCI was found in cirrhosis group compared with control group (P<0 01) .Serum insulin level was increased and insulin release was delayed in patients group.There exist insulin resistance, hepatogenous glucose tolerance impairment, endogenous hyperinsulinemia and insulin releasing delay in cirrhosis patients, which is considered to be associated with hepatonic dysfunction. [WT5”HZ]
-
Key words:
- Cirrhosis Insulin Blood glucose /
-
[1]MatthewsDR , HoskerJP , RUDENSKIas , etal.Homeostasismodelassessment:insulinresistanceandbeta cellfunctionfromfastingplasmaglucoseandinsulinconcentrationinman .Diabetologia , 1985 , 2 8∶412 [][2 ]HaffnerSM , GonzalezC , MiettnenH , etal.AprospectiveanalysisoftheHomamodel.TheMexicoCitydiabetesstudy .DiabetesCare , 1996, 19∶113 8 [][3 ]FraserGM , HarmanI, MellerN , etal.DiabetesmellitusisassociatedwithchronichepatitisCbutnotchronichepatitisBinfection .IsrJMedSci, 1996, 3 2 ( 7) ∶5 2 6 [4]RiggioO , MerliM , LeonettiF , etal.Impairednonoxidativeglucosemetabolisminpatientswithlivercirrhosis :effectsoftwoinsulindoses .Metabolism , 1997, 46 ( 7) ∶840 [][5 ]WuJ , LinsstromP , DanielssonA , etal.Insulinsecretioninpancreaticisletsfromratswithcirrhosis .JHepatol, 1994, 2 1∶3 3 2 -
本文二维码
计量
- 文章访问数: 2625
- HTML全文浏览量: 16
- PDF下载量: 25
- 被引次数: 0
下载:
