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Research of T lymphocyte subtypes and the phagocytosis activity of macrophages in the patients with virul hepatitis
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摘要: 为探讨病毒性肝炎患者体内细胞免疫功能的变化规律及相互关系。采用APAAP法、斑蝥皮泡法检测T细胞亚群、巨噬细胞吞噬率 （PR）及吞噬指数 （PI） ,并分析其相互关系。结果显示病毒性肝炎组CD3+ 细胞、CD4+ 细胞、CD4+ /CD8+ 比值降低、CD8+ 细胞升高 ,与对照组比较有显著差异 （P <0 0 1） ,各型病毒性肝炎组病人PR与CD4+ /CD8+ 比值正相关 ,其中CAH组相关系数r =0 76 4（P <0 0 5 ）。病毒性肝炎患者T细胞及巨噬细胞免疫功能均降低 ,且密切相关。结果有助于了解病毒性肝炎患者免疫功能的整体变化 ,对病毒性肝炎的免疫学诊断及免疫功能调整有一定意义。Abstract: WT5”BZ] To Detect T lymphocyte, macrophages immune function in the patients with virul hepatitis. T lymphocyte subtypes including CD3 +、CD4 +、CD8 + and phagocytosis rate (PR) and index (PI) of macrophages were measured in virul hepatitis. The results showned that the values of CD3 +、CD4 +、CD4 +/CD8 + were lower and CD8 + were higher in the virul hepatitis patients than in nomal control (P<0 01) ;The values of PR and PI were lower in patients than in controls (P<0 01) ;The values of PR and CD4 +/CD8 + were closely related in patients. T lymphocyte immune function, the phagocytosis activity of macrophages in virul hepatitis patients were significantly decreased, the changes of determent values of the two systems were closely interrelated. [WT5”HZ]
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Key words:
- Virul hepatitis /
- T lymphocyte /
- Macrophages
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[1]沈玉清 , 高德华 .巨噬细胞计数及功能检测。免疫学与免疫检验学。北京 :中国医药科技出版社 , 1989∶13 3 [][2 ]甑真 , 王麟士 , 曹治宸 , 等 .病毒性肝炎患者血清IL -6和T细胞亚群的关系。中华微生物学和免疫学杂志 , 1996, 16 ( 4 ) ∶3 0 2 [][3 ]张汉源 .各型肝炎肝组织内淋巴细胞亚群的免疫组织化学分析。同济医科大学学报 , 1989, 18 ( 4 ) ∶2 2 5 -
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