胆汁淤积性肝病的诊治现状及研究方向

于乐成; 陈成伟

doi:10.3969/j.issn.1001-5256.2019.02.001

胆汁淤积性肝病的诊治现状及研究方向

DOI: 10.3969/j.issn.1001-5256.2019.02.001

1. 解放军东部战区总医院/南京中医药大学附属八一医院全军肝病中心
2. 海军军医大学九〇五医院临床肝病研究中心

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-02-20

Current status and research interests of the diagnosis and treatment of cholestatic liver disease

Liver Disease Center of PLA, General Hospital of Eastern Theater Command/Bayi Hospital Affiliated to Nanjing University of Chinese Medicine

摘要

摘要:
胆汁淤积性肝病(CSLD)是指能够引起胆汁淤积的多种肝病的集合和统称,其病因复杂,发病机制有待深入阐明,尚缺乏足够有效的治疗手段。近十余年来对CSLD的多个方面有了较多新认识,为其精准诊治提供了更多层面和更为有效的抓手,同时也反映了许多问题依然悬而未决,亟需继续深入研究。本期重点号从6大方面介绍了有关CSLD的研究进展和存在问题:(1) CSLD的"上升"病理生理学模式;(2)胆汁淤积导致肝纤维化的机制及处置对策;(3)肠肝循环和肠道微生态与CSLD的关系;(4)药物性胆汁淤积的发病机制和诊疗问题;(5)肝衰竭时胆汁淤积的发生机制及处置对策;(6)胆汁淤积性肝病的治疗靶点和药物研发进展等。
- 胆汁淤积 /
- 肝硬化 /
- 肠肝循环 /
- 肝功能衰竭 /
- 诊断 /
- 治疗学 /
- 述评
Abstract:
Cholestatic liver disease ( CSLD) is a group of liver diseases which can cause cholestasis and has a complex etiology. Its pathogenesis remains unclear, and there are still no effective treatment measures. In the recent decade, new achievements have been made on various aspects of CSLD, which provides more help to accurate diagnosis and treatment and reflects many pending issues which need further research. This article introduces the research advances and problems in CSLD from the following six aspects: the“ascending”pathophysiology of CSLD, mechanisms of cholestasis-induced liver fibrosis and related management measures, association of enterohepatic circulation and intestinal microbiota with CSLD, pathogenesis and diagnosis/treatment of drug-induced cholestasis, pathogenesis and management of liver failure-associated cholestasis, and research advances in treatment targets and drug research and development for CSLD.
- cholestasis /
- liver cirrhosis /
- enterohepatic circulation /
- liver failure /
- diagnosis /
- therapeutics /
- editorial

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参考文献(37)

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