中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 10
Oct.  2023
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(10): 2506-2512

Research advances in total pancreatectomy with autologous islet cell transplantation

DOI: 10.3969/j.issn.1001-5256.2023.10.033

  • Department of Organ Transplantation，Changzheng Hospital，The Second Affiliated Hospital of Navy Medical University，Shanghai 200003，China

Research funding:

General Project of National Natural Science Foundation of China (81971503)

More Information
  • Corresponding author: MAO Jiaxi， winds_1990@126.com （ORCID： 0000－0001－5006－6153）; GUO Wenyuan， guowenyuan@smmu.edu.cn （ORCID： 0000－0003－3313－3881）
  • Received Date: 2022-12-30
  • Published Date: 2023-10-30
    Abstract
  • Since the 1970s， patients with chronic pancreatitis （CP） have benefited from total pancreatectomy with autologous islet cell transplantation （TPAIT）. With the continuous development of surgical techniques and perioperative management over the past few decades， there have been improvements in islet cell function， insulin independence rate， and the survival rate of patients. This article summarizes the preoperative indications for TPAIT， the development of surgical operations， postoperative management and monitoring， and prognosis， so as to help clinicians learn more about TPAIT.

     

    • FullText(HTML)
  • loading
    • References(46)
  • [1]
    BALDWIN XL, WILLIAMS BM, SCHROPE B, et al. What is new with total pancreatectomy and autologous islet cell transplantation? review of current progress in the field[J]. J Clin Med, 2021, 10( 10): 2123. DOI: 10.3390/jcm10102123.
    [2]
    BELLIN MD, FREEMAN ML, GELRUD A, et al. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: Recommendations from PancreasFest[J]. Pancreatology, 2014, 14( 1): 27－ 35. DOI: 10.1016/j.pan.2013.10.009.
    [3]
    LI WL, FENG BZ, YANG YW, et al. Research progress on optimization strategies for microencapsulated islet transplantation[J]. Ogran Transplant, 2022, 13( 2): 258－ 265. DOI: 10.3969/j.issn.1674－7445.2022.02.016.

    李万里, 丰丙政, 杨玉伟, 等. 微囊化胰岛移植优化策略研究进展[J]. 器官移植, 2022, 13( 2): 258－ 265. DOI: 10.3969/j.issn.1674－7445.2022.02.016.
    [4]
    BALZANO G, MAFFI P, NANO R, et al. Autologous islet transplantation in patients requiring pancreatectomy: A broader spectrum of indications beyond chronic pancreatitis[J]. Am J Transplant, 2016, 16( 6): 1812－ 1826. DOI: 10.1111/ajt.13656.
    [5]
    ABU－EL－HAIJA M, ANAZAWA T, BEILMAN GJ, et al. The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis[J]. Pancreatology, 2020, 20( 4): 762－ 771. DOI: 10.1016/j.pan.2020.04.005.
    [6]
    LIU Y, CHEN HW. Clinical islet transplantation: Application and challenge[J/CD]. Chin J Hepatic Surg Electron Ed, 2021, 10( 4): 352－ 356. DOI: 10.3877/cma.j.issn.2095－3232.2021.04.003.

    刘颖, 陈焕伟. 临床胰岛移植: 应用及挑战[J/CD]. 中华肝脏外科手术学电子杂志, 2021, 10( 4): 352－ 356. DOI: 10.3877/cma.j.issn.2095－3232.2021.04.003.
    [7]
    FAN CJ, HIROSE K, WALSH CM, et al. Laparoscopic total pancreatectomy with islet autotransplantation and intraoperative islet separation as a treatment for patients with chronic pancreatitis[J]. JAMA Surg, 2017, 152( 6): 550－ 556. DOI: 10.1001/jamasurg.2016.5707.
    [8]
    NATHAN JD, YANG Y, EATON A, et al. Surgical approach and short－term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT[J]. Pancreatology, 2022, 22( 1): 1－ 8. DOI: 10.1016/j.pan.2021.09.011.
    [9]
    POLLARD C, GRAVANTE G, WEBB M, et al. Use of the recanalised umbilical vein for islet autotransplantation following total pancreatectomy[J]. Pancreatology, 2011, 11( 2): 233－ 239. DOI: 10.1159/000324273.
    [10]
    TOLEDO－PEREYRA LH, BANDLIEN KO, GORDON DA, et al. Renal subcapsular islet cell transplantation[J]. Diabetes, 1984, 33( 9): 910－ 914. DOI: 10.2337/diabetes.33.9.910.
    [11]
    MCEACHRON KR, YANG Y, HODGES JS, et al. Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation－a retrospective study[J]. Transpl Int, 2021, 34( 1): 87－ 96. DOI: 10.1111/tri.13762.
    [12]
    MCEACHRON KR, POTLAPALLI N, RAYANNAVAR A, et al. Early use of continuous glucose monitoring in children and adolescents after total pancreatectomy with islet autotransplantation[J]. Pediatr Diabetes, 2021, 22( 3): 434－ 438. DOI: 10.1111/pedi.13168.
    [13]
    GOŁĘBIEWSKA JE, BACHUL PJ, FILLMAN N, et al. Assessment of simple indices based on a single fasting blood sample as a tool to estimate beta－cell function after total pancreatectomy with islet autotransplantation－ a prospective study[J]. Transpl Int, 2019, 32( 3): 280－ 290. DOI: 10.1111/tri.13364.
    [14]
    BACHUL PJ, GOŁĘBIEWSKA JE, BASTO L, et al. BETA－2 score is an early predictor of graft decline and loss of insulin independence after pancreatic islet allotransplantation[J]. Am J Transplant, 2020, 20( 3): 844－ 851. DOI: 10.1111/ajt.15645.
    [15]
    BACHUL PJ, GOLAB K, BASTO L, et al. Long－term stability of β－cell graft function after total pancreatectomy and islet autotransplantation[J]. Pancreas, 2021, 50( 1): e2－e4. DOI: 10.1097/MPA.0000000000001711.
    [16]
    TAKITA M, NAZIRUDDIN B, MATSUMOTO S, et al. Variables associated with islet yield in autologous islet cell transplantation for chronic pancreatitis[J]. Proc(Bayl Univ Med Cent), 2010, 23( 2): 115－ 120. DOI: 10.1080/08998280.2010.11928597.
    [17]
    BOUCHER AA, WASTVEDT S, HODGES JS, et al. Portal vein thrombosis may be more strongly associated with islet infusion than extreme thrombocytosis after total pancreatectomy with islet autotransplantation[J]. Transplantation, 2021, 105( 11): 2499－ 2506. DOI: 10.1097/TP.0000000000003624.
    [18]
    CHUNG WY, POLLARD CA, KUMAR R, et al. A comparison of the inflammatory response following autologous compared with allogenic islet cell transplantation[J]. Ann Transl Med, 2021, 9( 2): 98. DOI: 10.21037/atm－20－3519.
    [19]
    WITKOWSKI P, WIJKSTROM M, BACHUL PJ, et al. Targeting CXCR1/2 in the first multicenter, double－blinded, randomized trial in autologous islet transplant recipients[J]. Am J Transplant, 2021, 21( 11): 3714－ 3724. DOI: 10.1111/ajt.16695.
    [20]
    NAZIRUDDIN B, KANAK MA, CHANG CA, et al. Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL－1β and TNFα[J]. Am J Transplant, 2018, 18( 9): 2322－ 2329. DOI: 10.1111/ajt.14961.
    [21]
    WILLIAMS BM, BALDWIN X, VONDERAU JS, et al. Portal flow dynamics after total pancreatectomy and autologous islet cell transplantation[J]. Clin Transplant, 2020, 34( 12): e14112. DOI: 10.1111/ctr.14112.
    [22]
    DESAI CS, SZEMPRUCH KR, VONDERAU JS, et al. Anticoagulation practices in total pancreatectomy with autologous islet cell transplant patients: An international survey of clinical programs[J]. Transpl Int, 2021, 34( 3): 593－ 595. DOI: 10.1111/tri.13821.
    [23]
    SCHROPE B. Total pancreatectomy with autologous islet cell transplantation[J]. Gastrointest Endosc Clin N Am, 2018, 28( 4): 605－ 618. DOI: 10.1016/j.giec.2018.05.003.
    [24]
    ZHANG SW, YAN HX, MA XQ, et al. Effects of different routes of heparin on instant blood－mediated inflammatory reaction after portal vein islet transplantation[J]. J Cent South Univ Med Sci, 2022, 47( 1): 1－ 7. DOI: 10.11817/j.issn.1672－7347.2022.200993.

    张声旺, 颜海雄, 马小倩, 等. 不同路径肝素对门静脉胰岛移植术后立即经血液介导炎症反应的影响[J]. 中南大学学报(医学版), 2022, 47( 1): 1－ 7. DOI: 10.11817/j.issn.1672－7347.2022.200993.
    [25]
    BOUCHER AA, DONG M, VINKS AA, et al. Hydroxyurea pharmacokinetics in pediatric patients after total pancreatectomy with islet autotransplantation[J]. J Clin Pharmacol, 2021, 61( 4): 547－ 554. DOI: 10.1002/jcph.1759.
    [26]
    MCEACHRON KR, YANG Y, HODGES JS, et al. Alterations in enteroendocrine hormones after total pancreatectomy with islet autotransplantation[J]. Pancreas, 2020, 49( 6): 806－ 811. DOI: 10.1097/MPA.0000000000001582.
    [27]
    ROBERTSON RP. Spontaneous hypoglycemia after islet transplantation: The case for using non－hepatic sites[J]. J Clin Endocrinol Metab, 2016, 101( 10): 3571－ 3574. DOI: 10.1210/jc.2016－2850.
    [28]
    CUI HL, XU L, LU T. Association of glucagon－like peptide－1 system with the prevention and treatment of nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2022, 38( 6): 1406－ 1410. DOI: 10.3969/j.issn.1001－5256.2022.06.039.

    崔泓亮, 徐立, 鲁彤. 胰高血糖素样肽1系统与非酒精性脂肪性肝病防治的关系[J]. 临床肝胆病杂志, 2022, 38( 6): 1406－ 1410. DOI: 10.3969/j.issn.1001－5256.2022.06.039.
    [29]
    DHIR G, CUSI K. Glucagon like peptide－1 receptor agonists for the management of obesity and non－alcoholic fatty liver disease: A novel therapeutic option[J]. J Investig Med, 2018, 66( 1): 7－ 10. DOI: 10.1136/jim－2017－000554.
    [30]
    HE LP, SONG YX, ZHU T, et al. Progress in the relationship between vitamin D deficiency and the incidence of type 1 diabetes mellitus in children[J]. J Diabetes Res, 2022, 2022: 5953562. DOI: 10.1155/2022/5953562.
    [31]
    MCEACHRON KR, DOWNS EM, SCHWARZENBERG SJ, et al. Fat－soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation[J]. J Pediatr Gastroenterol Nutr, 2021, 72( 1): 123－ 126. DOI: 10.1097/MPG.0000000000002950.
    [32]
    NANNO Y, WASTVEDT S, FREEMAN ML, et al. Metabolic measures before surgery and long－term diabetes outcomes in recipients of total pancreatectomy and islet autotransplantation[J]. Am J Transplant, 2021, 21( 10): 3411－ 3420. DOI: 10.1111/ajt.16573.
    [33]
    BRAMIS K, GORDON－WEEKS AN, FRIEND PJ, et al. Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis[J]. Br J Surg, 2012, 99( 6): 761－ 766. DOI: 10.1002/bjs.8713.
    [34]
    HARINDHANAVUDHI T, YANG Y, HODGES JS, et al. Body composition is associated with islet function after pancreatectomy and islet autotransplantation for pancreatitis[J]. J Clin Endocrinol Metab, 2021, 106( 2): e496－e506. DOI: 10.1210/clinem/dgaa790.
    [35]
    FURBETTA N, COMANDATORE A, GIANARDI D, et al. Perioperative nutritional aspects in total pancreatectomy: A comprehensive review of the literature[J]. Nutrients, 2021, 13( 6): 1765. DOI: 10.3390/nu13061765.
    [36]
    DESAI CS, KHAN KM, MA XB, et al. Effect of liver histopathology on islet cell engraftment in the model mimicking autologous islet cell transplantation[J]. Islets, 2017, 9( 6): 140－ 149. DOI: 10.1080/19382014.2017.1356558.
    [37]
    GRYBOWSKI D, BACHUL PJ, PYDA JS, et al. Pain resolution and glucose control in pediatric patients with chronic pancreatitis after total pancreatectomy with islet auto－transplantation[J]. Pediatr Surg Int, 2021, 37( 10): 1383－ 1392. DOI: 10.1007/s00383－021－04956－5.
    [38]
    SOLOMINA J, GOŁĘBIEWSKA J, KIJEK MR, et al. Pain control, glucose control, and quality of life in patients with chronic pancreatitis after total pancreatectomy with islet autotransplantation: A preliminary report[J]. Transplant Proc, 2017, 49( 10): 2333－ 2339. DOI: 10.1016/j.transproceed.2017.10.010.
    [39]
    CHINNAKOTLA S, BELLIN MD, SCHWARZENBERG SJ, et al. Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: Indication, surgical techniques, postoperative management, and long－term outcomes[J]. Ann Surg, 2014, 260( 1): 56－ 64. DOI: 10.1097/SLA.0000000000000569.
    [40]
    CHINNAKOTLA S, BEILMAN GJ, DUNN TB, et al. Factors predicting outcomes after a total pancreatectomy and islet autotransplantation lessons learned from over 500 cases[J]. Ann Surg, 2015, 262( 4): 610－ 622. DOI: 10.1097/SLA.0000000000001453.
    [41]
    SHAHBAZOV R, NAZIRUDDIN B, YADAV K, et al. Risk factors for early readmission after total pancreatectomy and islet auto transplantation[J]. HPB, 2018, 20( 2): 166－ 174. DOI: 10.1016/j.hpb.2017.08.033.
    [42]
    BUTTERFIELD JT, VAKAYIL VR, JOPPRU K, et al. Factors associated with morbidity following total pancreatectomy and islet autotransplantation: A NSQIP analysis[J]. Transplant Proc, 2021, 53( 2): 705－ 711. DOI: 10.1016/j.transproceed.2020.11.013.
    [43]
    WRAY CJ, AHMAD SA, LOWY AM, et al. Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions[J]. Pancreatology, 2005, 5( 6): 562－ 569. DOI: 10.1159/000087498.
    [44]
    GREGORY SH, COUSENS LP, van ROOIJEN N, et al. Complementary adhesion molecules promote neutrophil－Kupffer cell interaction and the elimination of bacteria taken up by the liver[J]. J Immunol, 2002, 168( 1): 308－ 315. DOI: 10.4049/jimmunol.168.1.308.
    [45]
    WOOD RP, MELENDEZ T, LANGNAS AN, et al. The viability of microorganisms in preservation solutions[J]. Transplantation, 1991, 51( 1): 239－ 241. DOI: 10.1097/00007890－199101000－00039.
    [46]
    KOTAGAL M, SLUSHER J, AHMAD S, et al. In－hospital and 90－day outcomes after total pancreatectomy with islet autotransplantation for pediatric chronic and acute recurrent pancreatitis[J]. Am J Transplant, 2019, 19( 4): 1187－ 1194. DOI: 10.1111/ajt.15150.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (218) PDF downloads(19) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return