Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

Zhaobin CHEN; Liyuan HUANG; Bingyuan WANG; Junping SHI; Jing ZHANG

doi:10.3969/j.issn.1001-5256.2023.10.025

Volume 39 Issue 10

Oct. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2023 > 39(10): 2454-2459

PDF( 961 KB)

Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

DOI: 10.3969/j.issn.1001-5256.2023.10.025

1.
School of Clinical Medicine，Jining Medical University，Jining，Shandong 272000，China
2.
Department of Elderly Gastroenterology，The First Affiliated Hospital of China Medical University，Shenyang 110000，China
3.
Department of Liver Diseases，The Affiliated Hospital of Hangzhou Normal University，Hangzhou 310000，China
4.
Department of Gastroenterology，Affiliated Hospital of Jining Medical University，Jining，Shandong 272000，China

Research funding:

‍Project of Medical and Health Technology Development Program in Shandong Province (2019WS366);

PhD Research Foundation of Jining Medical University (2017－BS－007);

Natural Science Foundation of Shandong Province (ZR2019PH068)

More Information

Corresponding author: ZHANG Jing， zhangjing8809@126.com （ORCID： 0000－0003－2502－3156）
Received Date: 2022-12-28
Published Date: 2023-10-30

Abstract

Abstract

There are gradual increases in the incidence rates of metabolic associated fatty liver disease （MAFLD） and type 2 diabetes mellitus （T2DM）， with close relationship and mutual interaction between the two diseases， but the specific mechanism is still unclear. Studies have shown that T2DM and MAFLD may cause aggravation of each other through insulin resistance， inflammation， some hepatocyte factors， and cellular senescence and protect each other through some hepatocyte factors. Further research on the association between T2DM and MAFLD and the mechanism of comorbidity is of great significance for the clinical prevention and treatment of the two diseases.
- Diabetes Mellitus， Type 2,
- Metabolic Associated Fatty Liver Disease,
- Insulin Resistance,
- Inflammation,
- Cytokines,
- Cellular Senescence

FullText(HTML)

References(45)

References

[1]	ESLAM M, NEWSOME PN, SARIN SK, et al. A new definition for metabolic dysfunction－associated fatty liver disease: An international expert consensus statement[J]. J Hepatol, 2020, 73( 1): 202－ 209. DOI: 10.1016/j.jhep.2020.03.039.
[2]	National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association, Fatty Liver Expert Committee, Chinese Medical Doctor Association. Guidelines of prevention and treatment for nonalcoholic fatty liver disease: A 2018 update[J]. J Clin Hepatol, 2018, 34( 5): 947－ 957. DOI: 10.3969/j.issn.1001－5256.2018.05.007. 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 非酒精性脂肪性肝病防治指南(2018年更新版)[J]. 临床肝胆病杂志, 2018, 34( 5): 947－ 957. DOI: 10.3969/j.issn.1001－5256.2018.05.007.
[3]	YOUNOSSI ZM, KOENIG AB, ABDELATIF D, et al. Global epidemiology of nonalcoholic fatty liver disease－Meta－analytic assessment of prevalence, incidence, and outcomes[J]. Hepatology, 2016, 64( 1): 73－ 84. DOI: 10.1002/hep.28431.
[4]	Chinese Diabetes Society. Guidelines for the prevention and treatment of type 2 diabetes in china(2020 edition)[J]. Int J Endocrinol Metab, 2021, 41( 5): 482－ 548. DOI: 10.3760/cma.j.cn121383－20210825－08063. 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 国际内分泌代谢杂志, 2021, 41( 5): 482－ 548. DOI: 10.3760/cma.j.cn121383－20210825－08063.
[5]	BUNGAU S, BEHL T, TIT DM, et al. Interactions between leptin and insulin resistance in patients with prediabetes, with and without NAFLD[J]. Exp Ther Med, 2020, 20( 6): 197. DOI: 10.3892/etm.2020.9327.
[6]	LONARDO A, BALLESTRI S, MARCHESINI G, et al. Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome[J]. Dig Liver Dis, 2015, 47( 3): 181－ 190. DOI: 10.1016/j.dld.2014.09.020.
[7]	ADAMS LA, ANSTEE QM, TILG H, et al. Non－alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases[J]. Gut, 2017, 66( 6): 1138－ 1153. DOI: 10.1136/gutjnl－2017－313884.
[8]	YOUNOSSI ZM, GOLABI P, de AVILA L, et al. The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta－analysis[J]. J Hepatol, 2019, 71( 4): 793－ 801. DOI: 10.1016/j.jhep.2019.06.021.
[9]	PORTILLO－SANCHEZ P, BRIL F, MAXIMOS M, et al. High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels[J]. J Clin Endocrinol Metab, 2015, 100( 6): 2231－ 2238. DOI: 10.1210/jc.2015－1966.
[10]	WILD SH, MORLING JR, MCALLISTER DA, et al. Type 2 diabetes and risk of hospital admission or death for chronic liver diseases[J]. J Hepatol, 2016, 64( 6): 1358－ 1364. DOI: 10.1016/j.jhep.2016.01.014.
[11]	LEE SH, PARK SY, CHOI CS. Insulin resistance: from mechanisms to therapeutic strategies[J]. Diabetes Metab J, 2022, 46( 1): 15－ 37. DOI: 10.4093/dmj.2021.0280.
[12]	SZENDROEDI J, YOSHIMURA T, PHIELIX E, et al. Role of diacylglycerol activation of PKCθ in lipid－induced muscle insulin resistance in humans[J]. Proc Natl Acad Sci U S A, 2014, 111( 26): 9597－ 9602. DOI: 10.1073/pnas.1409229111.
[13]	MENG FS, WANG XY, QI F, et al. Analysis of the mechanism and factors of IR in T2DM and its prevention and treatment strategy[J]. J Liaoning Univ Tradit Chin Med, 2023, 25( 2): 128－ 132. DOI: 10.13194/j.issn.1673－842x.2023.02.026. 孟繁硕, 王晓蕴, 齐峰, 等. 2型糖尿病胰岛素抵抗机制、因素分析与防治策略[J]. 辽宁中医药大学学报, 2023, 25( 2): 128－ 132. DOI: 10.13194/j.issn.1673－842x.2023.02.026.
[14]	SHI XT, XU YN, WANG M, et al. Research progress of adipokines in nonalcoholic fatty liver disease[J]. China Med Herald, 2022, 19( 19): 41－ 44, 65. 石项天, 徐亚楠, 王猛, 等. 脂质因子在非酒精性脂肪肝病中作用机制研究进展[J]. 中国医药导报, 2022, 19( 19): 41－ 44,65.
[15]	TANASE DM, GOSAV EM, COSTEA CF, et al. The intricate relationship between type 2 diabetes mellitus(T2DM), insulin resistance(IR), and nonalcoholic fatty liver disease(NAFLD)[J]. J Diabetes Res, 2020, 2020: 3920196. DOI: 10.1155/2020/3920196.
[16]	MIKAMI K, ENDO T, SAWADA N, et al. Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population[J]. Cytokine, 2020, 126: 154927. DOI: 10.1016/j.cyto.2019.154927.
[17]	AHMED ES, MOHAMED HE, FARRAG MA. Luteolin loaded on zinc oxide nanoparticles ameliorates non－alcoholic fatty liver disease associated with insulin resistance in diabetic rats via regulation of PI3K/AKT/FoxO1 pathway[J]. Int J Immunopathol Pharmacol, 2022, 36: 3946320221137435. DOI: 10.1177/03946320221137435.
[18]	YU Y, MAGUIRE TG, ALWINE JC. ChREBP, a glucose－responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus－infected cells[J]. Proc Natl Acad Sci U S A, 2014, 111( 5): 1951－ 1956. DOI: 10.1073/pnas.1310779111.
[19]	FARZANEGI P, DANA A, EBRAHIMPOOR Z, et al. Mechanisms of beneficial effects of exercise training on non－alcoholic fatty liver disease(NAFLD): Roles of oxidative stress and inflammation[J]. Eur J Sport Sci, 2019, 19( 7): 994－ 1003. DOI: 10.1080/17461391.2019.1571114.
[20]	YUAN Y, LIU Q, ZHAO F, et al. Holothuria leucospilota polysaccharides ameliorate hyperlipidemia in high－fat diet－induced rats via short－chain fatty acids production and lipid metabolism regulation[J]. Int J Mol Sci, 2019, 20( 19): 4738. DOI: 10.3390/ijms20194738.
[21]	WU HZ, BALLANTYNE CM. Metabolic inflammation and insulin resistance in obesity[J]. Circ Res, 2020, 126( 11): 1549－ 1564. DOI: 10.1161/CIRCRESAHA.119.315896.
[22]	YUNG JHM, GIACCA A. Role of c－Jun N－terminal kinase(JNK) in obesity and type 2 diabetes[J]. Cells, 2020, 9( 3): 706. DOI: 10.3390/cells9030706.
[23]	DU H, DUAN SD, LEI R, et al. Astragalin inhibits insulin resistance and oxidative stress in palmitic acid－induced hepg2 cells[J]. Curr Top Nutraceutical Res, 2022, 20( 4): 635－ 640. DOI: 10.37290/ctnr2641－452X.20:635－640.
[24]	LEE J, WAN J, LEE L, et al. Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis[J]. Lipids Health Dis, 2017, 16( 1): 217. DOI: 10.1186/s12944－017－0595－2.
[25]	CHEN YL, QIAO YC, XU Y, et al. Serum TNF－α concentrations in type 2 diabetes mellitus patients and diabetic nephropathy patients: A systematic review and meta－analysis[J]. Immunol Lett, 2017, 186: 52－ 58. DOI: 10.1016/j.imlet.2017.04.003.
[26]	SUN TT, LI JT, WEI HL, et al. Research advances in the role of the TNF－α/NF－κB signaling pathway in the regulation of nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2019, 35( 9): 2095－ 2098. DOI: 10.3969/j.issn.1001－5256.2019.09.047. 孙婷婷, 李京涛, 魏海梁, 等. TNFα/NF－κB信号通路调控非酒精性脂肪性肝病的研究现状[J]. 临床肝胆病杂志, 2019, 35( 9): 2095－ 2098. DOI: 10.3969/j.issn.1001－5256.2019.09.047.
[27]	BAI SQ, NONG XL, ZHANG SQ, et al. Study on the effects of artesunate on liver of type 2 diabetic rats based on p38MAPK/IL－6 signal pathway[J]. J Guangxi Med Univ, 2022, 39( 4): 557－ 563. DOI: 10.16190/j.cnki.45－1211/r.2022.04.008. 白硕秋, 农晓琳, 张思琴, 等. 基于p38MAPK/IL－6信号通路研究青蒿琥酯对2型糖尿病大鼠肝脏的作用[J]. 广西医科大学学报, 2022, 39( 4): 557－ 563. DOI: 10.16190/j.cnki.45－1211/r.2022.04.008.
[28]	HENDAWY AS, EL－LAKKANY NM, MANTAWY EM, et al. Vildagliptin alleviates liver fibrosis in NASH diabetic rats via modulation of insulin resistance, oxidative stress, and inflammatory cascades[J]. Life Sci, 2022, 304: 120695. DOI: 10.1016/j.lfs.2022.120695.
[29]	LYU XR, GONG FY. Hepassocin:a novel hepatokine[J]. Int J Endocrinol Metab, 2019, 39( 5): 332－ 336. DOI: 10.3760/cma.j.issn.1673－4157.2019.05.011. 吕枭锐, 龚凤英. Hepassocin:一种新型的肝细胞因子[J]. 国际内分泌代谢杂志, 2019, 39( 5): 332－ 336. DOI: 10.3760/cma.j.issn.1673－4157.2019.05.011.
[30]	ROSHANZAMIR F, MIRAGHAJANI M, ROUHANI MH, et al. The association between circulating fetuin－A levels and type 2 diabetes mellitus risk: systematic review and meta－analysis of observational studies[J]. J Endocrinol Invest, 2018, 41( 1): 33－ 47. DOI: 10.1007/s40618－017－0697－8.
[31]	MONTGOMERY MK, BAYLISS J, NIE S, et al. Deep proteomic profiling unveils arylsulfatase A as a non－alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control[J]. Nat Commun, 2022, 13( 1): 1259. DOI: 10.1038/s41467－022－28889－2.
[32]	ZHANG LF, HAO YM. Study on selenoprotein p in type ２diabetes mellitus and non－alcoholic fatty liver disease[J]. J Baotou Med Coll, 2018, 34( 9): 95－ 96. DOI: 10.16833/j.cnki.jbmc.2018.09.040. 张利芳, 郝艳梅. 硒蛋白p水平与2型糖尿病和非酒精性脂肪肝关系的研究[J]. 包头医学院学报, 2018, 34( 9): 95－ 96. DOI: 10.16833/j.cnki.jbmc.2018.09.040.
[33]	KE Y, XU C, LIN J, et al. Role of hepatokines in non－alcoholic fatty liver disease[J]. J Transl Int Med, 2019, 7( 4): 143－ 148. DOI: 10.2478/jtim－2019－0029.
[34]	GU L, ZHANG Y, ZHANG S, et al. Coix lacryma－JOBI seed oil reduces fat accumulation in nonalcoholic fatty liver disease by inhibiting the activation of the p－AMPK/SePP1/apoER2 pathway[J]. J Oleo Sci, 2021, 70( 5): 685－ 696. DOI: 10.5650/jos.ess20255.
[35]	CHO YM, KIM DH, LEE KH, et al. The IRE1α－XBP1s pathway promotes insulin－stimulated glucose uptake in adipocytes by increasing PPARγ activity[J]. Exp Mol Med, 2018, 50( 8): 1－ 15. DOI: 10.1038/s12276－018－0131－0.
[36]	REGULSKI MJ. Cellular senescence: what, why, and how[J]. Wounds, 2017, 29( 6): 168－ 174.
[37]	DEEVSKA G, DOTSON PN, MITOV M, et al. Onset of senescence and steatosis in hepatocytes as a consequence of a shift in the diacylglycerol/ceramide balance at the plasma membrane[J]. Cells, 2021, 10( 6): 1278. DOI: 10.3390/cells10061278.
[38]	WAN Y, LIU Z, WU A, et al. Hyperglycemia promotes endothelial cell senescence through AQR/PLAU signaling axis[J]. Int J Mol Sci, 2022, 23( 5): 2879. DOI: 10.3390/ijms23052879.
[39]	LIU Y, GUO J, ZHANG ML, et al. Study of fistular onion stalk extract activating mitochondrial metabolism on non－alcoholic fatty liver disease rats by inducing pgc－1α[J]. Tianjin J Tradit Chin Med, 2021, 38( 2): 247－ 253. DOI: 10.11656/j.issn.1672－1519.2021.02.22. 刘云, 郭洁, 张曼玲, 等. 葱白提取物诱导pgc－1α活化非酒精性脂肪性肝病大鼠线粒体代谢的研究[J]. 天津中医药, 2021, 38( 2): 247－ 253. DOI: 10.11656/j.issn.1672－1519.2021.02.22.
[40]	ENGELMANN C, TACKE F. The potential role of cellular senescence in non－alcoholic fatty liver disease[J]. Int J Mol Sci, 2022, 23( 2): 652. DOI: 10.3390/ijms23020652.
[41]	ROBBINS PD, JURK D, KHOSLA S, et al. Senolytic drugs: reducing senescent cell viability to extend health span[J]. Annu Rev Pharmacol Toxicol, 2021, 61: 779－ 803. DOI: 10.1146/annurev－pharmtox－050120－105018.
[42]	NARASIMHAN A, FLORES RR, ROBBINS PD, et al. Role of cellular senescence in type ii diabetes[J]. Endocrinology, 2021, 162( 10): bqab136. DOI: 10.1210/endocr/bqab136.
[43]	MEIJNIKMAN AS, HERREMA H, SCHEITHAUER T, et al. Evaluating causality of cellular senescence in non－alcoholic fatty liver disease[J]. JHEP Rep, 2021, 3( 4): 100301. DOI: 10.1016/j.jhepr.2021.100301.
[44]	ZHANG CY, TAN XH, YANG HH, et al. COX－2/sEH dual inhibitor alleviates hepatocyte senescence in NAFLD mice by restoring autophagy through Sirt1/PI3K/AKT/mTOR[J]. Int J Mol Sci, 2022, 23( 15): 8267. DOI: 10.3390/ijms23158267.
[45]	VACUROVA E, TRNOVSKA J, SVOBODA P, et al. Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice[J]. Nat Commun, 2022, 13( 1): 1866. DOI: 10.1038/s41467－022－29486－z.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (395) PDF downloads(104)

Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

DOI: 10.3969/j.issn.1001-5256.2023.10.025

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity

DOI: 10.3969/j.issn.1001-5256.2023.10.025

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content