Research advances in ATP－binding cassette transporter G5/8 and cholesterol gallstones

Qin LU; Weihui LIU

doi:10.3969/j.issn.1001-5256.2023.09.033

Volume 39 Issue 9

Sep. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(9): 2252-2257

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Research advances in ATP－binding cassette transporter G5/8 and cholesterol gallstones

DOI: 10.3969/j.issn.1001-5256.2023.09.033

Qin LU^{1, 2},
Weihui LIU^{1, 2
,
,
,}

1.
School of Medicine，University of Electronic Science and Technology of China，Chengdu 611731，China
2.
Department of Gastroenterology and Hepatology，Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital，Chengdu 610072，China

Research funding:

Key Project of Science and Technology Department of Sichuan Province (2021YFS0375)

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Corresponding author: LIU Weihui， audiliu12@163.com （ORCID： 0000－0003－2871－8316）
Received Date: 2022-12-11
Accepted Date: 2023-01-19
Published Date: 2023-09-19

Abstract

Abstract

Cholesterol stone is a common type of gallstones and is affected by a variety of controllable and uncontrollable factors. In recent years， extensive studies have been conducted on genetic factors， especially their role in the formation mechanism of cholesterol stones. The ATP－binding cassette family is the largest membrane transporter family in human and plays a key role in maintaining lipid and sterol homeostasis. ATP－binding cassette transporter G5/8 （ABCG5/8） is a cholesterol transporter that participates in the regulation of cholesterol levels in the body and is considered the main genetic susceptibility factor for cholesterol gallstones in humans. This article reviews the research advances in ABCG5/8 in the formation of cholesterol gallstones and introduces the possibility of targeting ABCG5/8 in the treatment of cholesterol gallstones， in order to provide a certain theoretical basis for investigating the etiology and clinical treatment of cholesterol gallstones.
- ATP－binding Cassette,
- Cholecystolithiasis,
- Therapeutics,
- Genetic Predisposition to Disease

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References(49)

References

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Research advances in ATP－binding cassette transporter G5/8 and cholesterol gallstones

DOI: 10.3969/j.issn.1001-5256.2023.09.033

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Research advances in ATP－binding cassette transporter G5/8 and cholesterol gallstones

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