Risk factors for non－neoplastic portal vein thrombosis in patients with liver cirrhosis

Tianfu LIU; Liang WANG; Lingyi ZHANG

doi:10.3969/j.issn.1001-5256.2023.09.014

Volume 39 Issue 9

Sep. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(9): 2122-2127

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Risk factors for non－neoplastic portal vein thrombosis in patients with liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2023.09.014

Department of Hepatology，The Second Hospital of Lanzhou University，Lanzhou 730030，China

Research funding:

Education Technology Innovation Project of Gansu Province (2022B－047);

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (CY2021－QN－A18)

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Corresponding author: ZHANG Lingyi， zhanglymd@126.com （ORCID： 0000－0002－0434－7533）
Received Date: 2023-02-08
Accepted Date: 2023-03-08
Published Date: 2023-09-19

Abstract

Abstract

Objective To investigate the risk factors for non－neoplastic portal vein thrombosis （PVT） in patients with liver cirrhosis and related early predictive factors. Methods A total of 50 cirrhotic patients with non－neoplastic PVT who were hospitalized and treated in Department of Hepatology， The Second Hospital of Lanzhou University， from July 1， 2021 to June 30， 2022 were enrolled as PVT group， and 100 cirrhotic patients without PVT who were treated during the same period of time were randomly selected as control group. Related clinical data were collected. The independent－samples t test was used for comparison of normally distributed continuous data between two groups， and the Mann－Whitney U test was used for comparison of non－normally distributed continuous data between two groups； the chi－square test was used for comparison of categorical data between two groups. A multivariate Logistic regression model analysis was used to investigate the influencing factors for PVT in liver cirrhosis， and the receiver operating characteristic curve was used to evaluate the predictive performance of influencing factors. Results The univariate analysis showed that there were no significant differences between the two groups in the indicators such as protein C， protein S， prothrombin time， international standardized ratio， fibrinogen， white blood cell count， platelet count， and biochemical parameters （all P>0.05）， while there were significant differences between the two groups in history of splenectomy， history of endoscopic treatment of esophageal and gastric varices， history of hepatic encephalopathy， administration of non－selective β－blocker （NSBB）， D－dimer， hemoglobin， and triglyceride （all P<0.05）. The multivariate Logistic regression model analysis showed that D－dimer （odds ratio ［OR］＝1.120， 95% confidence interval ［CI］： 1.006－1.246， P＝0.038）， history of splenectomy （OR＝9.320， 95% CI： 2.928－29.665， P<0.001）， history of hepatic encephalopathy （OR＝16.813， 95% CI： 1.808－156.336， P＝0.013）， and administration of NSBB （OR＝3.203， 95% CI： 1.020－10.051， P＝0.046） were independent risk factors for PVT. Conclusion Elevated D－dimer， history of splenectomy， history of hepatic encephalopathy， and administration of NSBB are predictive factors for non－neoplastic PVT in patients with liver cirrhosis.
- Liver Cirrhosis,
- Venous Thrombosis,
- Risk Factors

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References(23)

References

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Risk factors for non－neoplastic portal vein thrombosis in patients with liver cirrhosis

DOI: 10.3969/j.issn.1001-5256.2023.09.014

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