Changes and pathogenic mechanism of intestinal flora in acute-on-chronic liver failure

Guirong CHEN; Minggang WANG; Huaming LIN; Huiping YAN; Xiufeng WANG

doi:10.3969/j.issn.1001-5256.2023.08.034

Volume 39 Issue 8

Aug. 2023

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Changes and pathogenic mechanism of intestinal flora in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.08.034

1.
Graduate School of Guangxi University of Chinese Medicine, Nanning 530222, China
2a.
Department of Scientific Research, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
2b.
First Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

Natural Science Foundation of Guangxi Zhuang Autonomous Region (2018GXNSFGA281002);

Natural Science Foundation of Guangxi Zhuang Autonomous Region (2018GXNSFBA281031);

Guangxi Postgraduate Education Innovation Program (YCSY2022027)

More Information

Corresponding author: WANG Xiufeng, 52912236@qq.com (ORCID: 0000-0003-0841-5908)
Received Date: 2022-10-24
Accepted Date: 2022-12-08
Published Date: 2023-08-20

Abstract

Abstract

Acute-on-chronic liver failure (ACLF) has a rapid onset, a high mortality rate, and a poor prognosis, and there is still a lack of specific pharmacotherapy and treatment methods. In recent years, an increasing number of evidence has shown that intestinal flora plays a critical role in maintaining the homeostasis of human microenvironment. Comprehensive testing of intestinal flora profile using metagenomics has demonstrated an interaction association between intestinal flora and the development and progression of chronic liver diseases. Research on the pathogenesis of ACLF has found that intestinal flora plays an important role in the pathogenesis of ACLF. Based on this, this article summarizes the changes in intestinal flora and its pathogenic mechanism in the development and progression of ACLF, so as to provide new targets for the clinical treatment of ACLF from the new perspective of intestinal flora regulation.
- Gastrointestinal Microbiome,
- Acute-On-Chronic Liver Failure,
- Bacterial Translocation

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References

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Changes and pathogenic mechanism of intestinal flora in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2023.08.034

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Changes and pathogenic mechanism of intestinal flora in acute-on-chronic liver failure

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