Role of new potential immune blocking molecules in the development and progression of hepatocellular carcinoma

Ying TAO; Zhangxiu LIAO

doi:10.3969/j.issn.1001-5256.2023.04.031

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 948-955

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Role of new potential immune blocking molecules in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.031

Ying TAO^{1, 2},
Zhangxiu LIAO^{1
,
,
,}

1.
School of Pharmacy, Youjiang Medical University for Nationalities, Bose, Guangxi 533000, China
2.
School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Bose, Guangxi 533000, China

Research funding:

National Natural Science Foundation of China (81660642);

Degree and Graduate Education Reform Project in Guangxi (JGY2022278)

More Information

Corresponding author: LIAO Zhangxiu, liaozhangxiu@163.com (ORCID: 0000-0001-5130-0642)
Received Date: 2022-08-03
Accepted Date: 2022-09-07
Published Date: 2023-04-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors around the world. The emergence of immune checkpoint inhibitors targeting programmed death-1/programmed death-ligand 1 and cytotoxic T lymphocyte-associated antigen-4 has brought great breakthroughs in the treatment of HCC. However, since HCC is a type of tumor with high heterogeneity, monotherapy is only effective for a small number of patients and may not be able to achieve long-lasting benefits due to drug resistance, and therefore, it is necessary to explore the potential of new immune checkpoint inhibitors in the prevention and treatment of HCC. This article analyzes and summarizes the biological characteristics of the new immune checkpoints T cell immunoglobulin and ITIM domain (TIGIT), V-domain immunoglobulin suppressor of T-cell activation (VISTA), B and T lymphocyte attenuator (BTLA), and B7 homologous protein-4 (B7-H4) and their expression and function in HCC. The analysis shows that TIGIT, VISTA, BTLA, and B7-H4 are highly expressed in HCC tissue and are associated with the prognosis of HCC patients, and targeted blocking of corresponding pathways can effectively inhibit the progression of HCC, suggesting that these molecules are potential targets for tumor treatment and that in-depth studies can provide new directions for HCC immunotherapy.
- Carcinoma, Hepatocellular,
- Immunosuppressive Agents,
- Molecular Targeted Therapy

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References(46)

References

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Role of new potential immune blocking molecules in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2023.04.031

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Role of new potential immune blocking molecules in the development and progression of hepatocellular carcinoma

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