Current research status of hepatitis D virus RNA detection

Yao GAO; Feng REN; Zhongping DUAN

doi:10.3969/j.issn.1001-5256.2023.04.004

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 758-765

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Current research status of hepatitis D virus RNA detection

DOI: 10.3969/j.issn.1001-5256.2023.04.004

Yao GAO^{1, 2},
Feng REN^{1, 2},
Zhongping DUAN^{1
,
,
,}

1.
Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
2.
Beijing Institute of Hepatology, Beijing 100069, China

Research funding:

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Projects of the Beijing Municipal Education Commission's Science and Technology Plan (KZ202010025035);

Special Key Research Project of Capital Health Development Scientific Research (SF2020-1-1151);

Pilot Project of Public Welfare Development and Reform of Beijing Municipal Medical Research Institutes (Beijing Medical Research No. 2021-10);

High-level Public Health Technical Personnel Construction Project (Subject leaders-02-13);

Talent Cultivation plan of "Climbing the peak" of Beijing Municipal Hospital Administration (DFL20221503);

Research and Cultivation Foundation of Capital Medical University (PYZ22130)

More Information

Corresponding author: DUAN Zhongping, duan2517@163.com (ORCID: 0000-0002-8455-0426)
Received Date: 2023-02-21
Accepted Date: 2023-03-21
Published Date: 2023-04-20

Abstract

Abstract

Hepatitis D caused by hepatitis D virus (HDV) infection is the most serious type of viral hepatitis. The prevalence rate of HDV has been seriously underestimated due to the lack of accurate HDV RNA detection methods. HDV RNA is the gold standard for the diagnosis of HDV infection and is of great significance in the diagnosis, screening, and treatment guidance of HDV. However, the multiple genotypes and strong secondary structure of HDV have led to great difficulties in HDV RNA detection. This article reviews the advances in HDV RNA detection methods and elaborates on the development from qualitative to quantitative detection methods, in order to provide new ideas for understanding the significance of HDV RNA detection and promoting the research and development of new HDV RNA detection methods.
- Hepatitis Delta Virus,
- RNA,
- Diagnosis

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References(45)

References

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Current research status of hepatitis D virus RNA detection

DOI: 10.3969/j.issn.1001-5256.2023.04.004

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