Research history of hepatitis D in China

Huimin LIU; Qing MAO

doi:10.3969/j.issn.1001-5256.2023.04.002

Volume 39 Issue 4

Apr. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(4): 742-750

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Research history of hepatitis D in China

DOI: 10.3969/j.issn.1001-5256.2023.04.002

Huimin LIU,
Qing MAO^{,
,}

Chongqing Key Laboratory of Infectious Disease Research, Institute of Infectious Diseases of PLA, Southwest Hospital, Army Medical University, Chongqing 400038, China

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Corresponding author: MAO Qing, qingmao@tmmu.edu.cn (ORCID: 0000-0003-3138-2104)
Received Date: 2023-02-15
Accepted Date: 2023-03-16
Published Date: 2023-04-20

Abstract

Abstract

Since the discovery of hepatitis D virus (HDV) in the 1970s, Chinese scholars have started to conduct extensive studies on HDV and hepatitis D (HD). By searching for related articles published on the platforms of Chinese scientific and technological journals and the journals in PubMed database by Chinese scholars, this article comprehensively analyzes and summarizes the advances and scientific findings in HDV and HD by Chinese scholars from basic to clinical research from the perspective of historical development. Over the past years, Chinese scholars have conducted extensive research on the establishment of detection techniques and methods, the construction of infected animal models, the function and application of ribozymes, and clinical diagnosis and manifestation. The research findings in the past 40 years have laid a foundation for further research on the virological characteristics, infection mechanism, and immune response and injury of HDV, the clinicopathological changes of HD, and related antiviral treatment.
- Hepatitis D,
- Hepatitis Delta Virus,
- China

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References

[1]	RIZZETTO M, CANESE MG, ARICÒ S, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers[J]. Gut, 1977, 18(12): 997-1003. DOI: 10.1136/gut.18.12.997.
[2]	RIZZETTO M, HOYER B, CANESE MG, et al. delta Agent: association of delta antigen with hepatitis B surface antigen and RNA in serum of delta-infected chimpanzees[J]. Proc Natl Acad Sci U S A, 1980, 77(10): 6124-6128. DOI: 10.1073/pnas.77.10.6124.
[3]	LU WL. Hepatitis δ factor: Hepatitis D[J]. Foreign Med Sci (InternMed), 1985, 12(3): 133-134. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLK198503012.htm 陆玮伦. δ肝炎因子: 丁型病毒性肝炎[J]. 国外医学(内科学分册), 1985, 12(3): 133-134. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLK198503012.htm
[4]	LI QX, REN ZY. Advances in the research of hepatitis virus[J]. Chin J Nature, 1987, 10(10): 768-772. https://www.cnki.com.cn/Article/CJFDTOTAL-ZRZZ198710011.htm 李秋香, 任中原. 肝炎病毒的研究进展[J]. 自然杂志, 1987, 10(10): 768-772. https://www.cnki.com.cn/Article/CJFDTOTAL-ZRZZ198710011.htm
[5]	LIANG LT. Hepatitis D (hepatitis δ)[J]. Med J Natl Defend Forces Northwest China, 1986(4): cover three, cover four. https://www.cnki.com.cn/Article/CJFDTOTAL-XBGY198604099.htm 梁烈庭. 丁型肝炎(δ肝炎)[J]. 西北国防医学杂志, 1986(4): 封三, 封四. https://www.cnki.com.cn/Article/CJFDTOTAL-XBGY198604099.htm
[6]	CHEN DS, LAI MY, SUNG JL. Delta agent infection in patients with chronic liver diseases and hepatocellular carcinoma—an infrequent finding in Taiwan[J]. Hepatology, 1984, 4(3): 502-503. DOI: 10.1002/hep.1840040324.
[7]	GOVINDARAJAN S, LEE SD, TONG MJ, et al. Prevalence of delta agent among Chinese in Taiwan and Los Angeles[J]. J Med Virol, 1984, 14(1): 33-37. DOI: 10.1002/jmv.1890140106.
[8]	SHARMEEN L, KUO MY, DINTER-GOTTLIEB G, et al. Antigenomic RNA of human hepatitis delta virus can undergo self-cleavage[J]. J Virol, 1988, 62(8): 2674-2679. DOI: 10.1128/JVI.62.8.2674-2679.1988.
[9]	HAO LJ. Hepatitis D virus infection[J]. Jiangsu Med J, 1989(5): 265-266. https://www.cnki.com.cn/Article/CJFDTOTAL-YIYA198905025.htm 郝连杰. 丁型肝炎病毒感染[J]. 江苏医药, 1989(5): 265-266. https://www.cnki.com.cn/Article/CJFDTOTAL-YIYA198905025.htm
[10]	SHAO LJ, ZHAN MY. Advances in the research for Molecular biology of hepatitis D virus[J]. Chin J Public Health, 1992, 11(5): 313-315, 320. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSX199205028.htm 邵立军, 詹美云. 丁型肝炎病毒分子生物学的研究进展[J]. 中国公共卫生学报, 1992, 11(5): 313-315, 320. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSX199205028.htm
[11]	ZHANG YY, HAO LJ. Recent development of studies for experimental infection and animalmodel of Hepatitis D virus[J]. Foreign Med Sci (Epidemiol Loimol), 1989(2): 71-73. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLX198902007.htm 张永源, 郝连杰. 丁型肝炎病毒实验感染与动物模型研究近况[J]. 国外医学(流行病学传染病学分册), 1989(2): 71-73. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLX198902007.htm
[12]	LI HW, MAO Q, LI QF. Inhibitory effect of replication and expression of HDV by antisense oligonucleotides in H₁δ₉ cell[J]. Chin J Hepatol, 1999, 7(1): 13. DOI: 10.3760/j.issn:1007-3418.1999.01.006. 李宏文, 毛青, 李奇芬. 反义寡核苷酸对H₁δ₉细胞中丁型肝炎病毒基因复制与表达的抑制作用[J]. 中华肝脏病杂志, 1999, 7(1): 13. DOI: 10.3760/j.issn:1007-3418.1999.01.006.
[13]	GUO HZ, MAO Q, LI QF, et al. Preliminary studies on the intracellular inhibiting activity of HDV ribozymes against HCV RNA[J]. J Third Milit Med Univ, 2004, 26(11): 960-962. DOI: 10.3321/j.issn:1000-5404.2004.11.008. 郭焕珍, 毛青, 李奇芬, 等. HepG2.9706细胞内HDV核酶对HCV RNA抑制活性的初步研究[J]. 第三军医大学学报, 2004, 26(11): 960-962. DOI: 10.3321/j.issn:1000-5404.2004.11.008.
[14]	LI QF, ZHENG H, WU CQ, et al. Application of synthetic 27 oligopeptide of HDV antigen for detecting serum anti-HD in HBV infected subjects in Chongqing[J]. Chin J Intern Med, 1994, 33(4): 237-240. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHNK404.012.htm 李奇芬, 郑红, 吴纯清, 等. 应用丁型肝炎病毒27肽抗原检测丁型肝炎病毒抗体[J]. 中华内科杂志, 1994, 33(4): 237-240. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHNK404.012.htm
[15]	MAO Q, WANG SQ, LI QF, et al. Antiviral effect of an antisense phosphorothioate oligodeoxynucleotides complementary to the nucleotides seqience of genomic HDV ribozyme[J]. Immunol J, 1996, 12(1): 5-8. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ601.001.htm 毛青, 王升启, 李奇芬, 等. 反义寡脱氧核苷酸抗丁型肝炎病毒的作用[J]. 免疫学杂志, 1996, 12(1): 5-8. https://www.cnki.com.cn/Article/CJFDTOTAL-MYXZ601.001.htm
[16]	MAO Q. Research Advance of hepatitis D virus ribozyme[J]. Foreign Med Sci (Epidemiol Loimol), 1995, 22(5): 216-219. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLX199505007.htm 毛青. 丁型肝炎病毒核酶研究进展[J]. 国外医学(流行病学传染病学分册), 1995, 22(5): 216-219. https://www.cnki.com.cn/Article/CJFDTOTAL-GWLX199505007.htm
[17]	MAO Q, WANG SQ, LI QF, et al. Reverse transcription "nested" polymerase chain reaction for detection of HDV RNA in serum samples[J]. Chin J Med Lab Sci, 1996, 19(2): 83-85. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYJ199602007.htm 毛青, 王升启, 李奇芬, 等. 聚合酶链反应检测血清丁型肝炎病毒核酸[J]. 中华医学检验杂志, 1996, 19(2): 83-85. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYJ199602007.htm
[18]	MAO Q, WANG SQ, LI QF, et al. Inhibition of genomic HDV ribozyme activity by antisense oligodeoxynucleotides[J]. Chin Med J, 1996, 76(1): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYX199601012.htm 毛青, 王升启, 李奇芬, 等. 反义寡脱氧核苷酸抑制丁型肝炎病毒基因链核酶活性的作用[J]. 中华医学杂志, 1996, 76(1): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYX199601012.htm
[19]	WAN H. Laboratory diagnosis of hepatitis D virus infection[J]. J Guangxi Med Univ, 1995, 12(1): 168-171. https://www.cnki.com.cn/Article/CJFDTOTAL-GXYD501.079.htm 万红. 丁型肝炎病毒感染的实验室诊断[J]. 广西医科大学学报, 1995, 12(1): 168-171. https://www.cnki.com.cn/Article/CJFDTOTAL-GXYD501.079.htm
[20]	CHAO M, HSIEH SY, TAYLOR J. Role of two forms of hepatitis delta virus antigen: evidence for a mechanism of self-limiting genome replication[J]. J Virol, 1990, 64(10): 5066-5069. DOI: 10.1128/JVI.64.10.5066-5069.1990.
[21]	BUTI M, ESTEBAN R, JARDI R, et al. Chronic delta hepatitis: detection of hepatitis delta virus antigen in serum by immunoblot and correlation with other markers of delta viral replication[J]. Hepatology, 1989, 10(6): 907-910. DOI: 10.1002/hep.1840100602.
[22]	POHL C, BAROUDY BM, BERGMANN KF, et al. A human monoclonal antibody that recognizes viral polypeptides and in vitro translation products of the genome of the hepatitis D virus[J]. J Infect Dis, 1987, 156(4): 622-629. DOI: 10.1093/infdis/156.4.622.
[23]	LIU BY, RAO HY. Research progress on the detection method of hepatitis D[J]. Chin J Hepatol, 2022, 30(10): 1022-1025. DOI: 10.3760/cma.j.cn501113-20221019-00504. 刘百怡, 饶慧瑛. 丁型肝炎检测方法研究进展[J]. 中华肝脏病杂志, 2022, 30(10): 1022-1025. DOI: 10.3760/cma.j.cn501113-20221019-00504.
[24]	NIU JZ, GUO KJ, EDWARDS P, et al. Application of Digoxigenin-labeled RNA probe in hepatitis D virus nucleic acid hybridization[J]. Virologica Sin, 1992, 7(2): 160-165. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBDX199202009.htm 牛建章, 郭可謇, EDWARDS P, 等. 异羟基洋地黄毒甙元(Digoxigenin)标记的RNA探针在丁型肝炎病毒核酸杂交中的应用[J]. 中国病毒学, 1992, 7(2): 160-165. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBDX199202009.htm
[25]	XU L, ZHANG X, CAO Y, et al. Digital droplet PCR for detection and quantitation of hepatitis delta virus[J]. Clin Transl Gastroenterol, 2022, 13(7): e00509. DOI: 10.14309/ctg.0000000000000509.
[26]	WANG C, SHEN X, LU J, et al. Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) system for rapid detection of HDV genotype 1[J]. Lett Appl Microbiol, 2013, 56(3): 229-235. DOI: 10.1111/lam.12039.
[27]	TAN WJ, ZHAN MY, YI YJ, et al. Screening, cloning and analysis of gene heterogeneity of antigen coding region for HDV cDNA in different regions and populations in China[J]. Virologica Sin, 1996, 11(3): 244-250. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBDX603.008.htm 谭文杰, 詹美云, 易炎杰, 等. 中国不同地区和人群HDV cDNA的筛选、克隆及抗原编码区基因异质性的分析[J]. 中国病毒学, 1996, 11(3): 244-250. https://www.cnki.com.cn/Article/CJFDTOTAL-ZBDX603.008.htm
[28]	SUN ZH, ZHENG WL, ZHANG B, et al. Preparation of the microarray for detecting hepatitis D virus[J]. J The First Military Med Univ, 2004, 24(1): 44-46, 49. DOI: 10.3321/j.issn:1673-4254.2004.01.013. 孙朝晖, 郑文岭, 张宝, 等. 基因芯片技术检测丁型肝炎病毒的研究[J]. 第一军医大学学报, 2004, 24(1): 44-46, 49. DOI: 10.3321/j.issn:1673-4254.2004.01.013.
[29]	PONZETTO A, COTE PJ, POPPER H, et al. Transmission of the hepatitis B virus-associated delta agent to the eastern woodchuck[J]. Proc Natl Acad Sci U S A, 1984, 81(7): 2208-2212. DOI: 10.1073/pnas.81.7.2208.
[30]	JIN ZH, YANG B, YANG XA, et al. Hepatitis D virus marmota monax woodchuck hepatitis virus[J]. Chin J Virol, 1990, 6(1): 74-76. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB199001011.htm 金志宏, 杨波, 杨小昂, 等. 丁型肝炎病毒感染东方土拔鼠的实验研究[J]. 病毒学报, 1990, 6(1): 74-76. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB199001011.htm
[31]	LI QF, MAO Q, WU CQ, et al. Pathological observation of the liver on experimental hepatitis in tupaiae[J]. Chin J Hepatol, 1996, 4(4): 210-213. 李奇芬, 毛青, 吴纯清, 等. 树鼩实验性丁型肝炎的病理观察[J]. 中华肝脏病杂志, 1996, 4(4): 210-213.
[32]	GUILHOT S, HUANG SN, XIA YP, et al. Expression of the hepatitis delta virus large and small antigens in transgenic mice[J]. J Virol, 1994, 68(2): 1052-1058. DOI: 10.1128/JVI.68.2.1052-1058.1994.
[33]	POLO JM, LIM B, GOVINDARAJAN S, et al. Replication of hepatitis delta virus RNA in mice after intramuscular injection of plasmid DNA[J]. J Virol, 1995, 69(8): 5203-5207. DOI: 10.1128/JVI.69.8.5203-5207.1995.
[34]	ZHOU ZM, LI WH. Research progress on animal models of hepatitis D infection[J]. Chin J Viral Dis, 2021, 11(6): 431-437. DOI: 10.16505/j.2095-0136.2021.0055. 周忠敏, 李文辉. 丁型肝炎病毒感染动物模型的研究进展[J]. 中国病毒病杂志, 2021, 11(6): 431-437. DOI: 10.16505/j.2095-0136.2021.0055.
[35]	WU HN, WANG YJ, HUNG CF, et al. Sequence and structure of the catalytic RNA of hepatitis delta virus genomic RNA[J]. J Mol Biol, 1992, 223(1): 233-245. DOI: 10.1016/0022-2836(92)90728-3.
[36]	YUE YC, MAO Q. Hepatitis D virus ribozyme and its application[J]. Foreign Med Sci (Microbiol), 1999, 22(3): 3-5. https://www.cnki.com.cn/Article/CJFDTOTAL-GWWZ199903001.htm 于乐成, 毛青. 丁型肝炎病毒核酶及其应用[J]. 国外医学(微生物学分册), 1999, 22(3): 3-5. https://www.cnki.com.cn/Article/CJFDTOTAL-GWWZ199903001.htm
[37]	YU YC, GU CH, MAO Q, et al. Reconstruction of hepatitis D virus ribozymes and their ability to trans-cleave hepatitis C virus RNA[J]. Chin J Hepatol, 2001, 9(3): 157-159. DOI: 10.3760/j.issn:1007-3418.2001.03.010. 于乐成, 顾长海, 毛青, 等. 丁型肝炎病毒核酶结构改建及其对丙型肝炎病毒RNA的剪切活性[J]. 中华肝脏病杂志, 2001, 9(3): 157-159. DOI: 10.3760/j.issn:1007-3418.2001.03.010.
[38]	ZOU YJ, ZHANG XL, LIAO K. Backtracking search for the folding pathway of the hepatitis delta virus ribozyme[J]. J Pingxiang Univ, 2020, 37(3): 79-84. DOI: 10.3969/j.issn.1007-9149.2020.03.016. 邹彦娟, 张小龙, 廖昆. 回溯搜索丁型肝炎病毒核酶的折叠路径[J]. 萍乡学院学报, 2020, 37(3): 79-84. DOI: 10.3969/j.issn.1007-9149.2020.03.016.
[39]	XU JY. Detection of δ antigen and anti-δ antibody in north China[J]. Chin J Microbiol Immunol, 1984, 4(2): 127-129. DOI: 10.3760/cma.j.issn.0254-5101.1984.02.120. 许健音. 我国北方一些地区δ抗原及其抗体的检测[J]. 中华微生物学和免疫学杂志, 1984, 4(2): 127-129. DOI: 10.3760/cma.j.issn.0254-5101.1984.02.120.
[40]	SUN NX. A preliminary report on the status of hepatitis D infection in Jiangsu Province[J]. J Nanjing Med Coll, 1987, 7(3): 173. https://www.cnki.com.cn/Article/CJFDTOTAL-NJYK198703002.htm 孙南雄. 江苏省D型肝炎感染状况的研究初报[J]. 南京医学院学报, 1987, 7(3): 173. https://www.cnki.com.cn/Article/CJFDTOTAL-NJYK198703002.htm
[41]	Bureau of Disease Control, Prevention and Control, 2015 National Epidemic Situation of Statutory Infectious Diseases[EB/OL]. http://www.nhc.gov.cn/jkj/s6873/201602/b9217ba14e17452aad9e45a5bcce6b65.shtml. 疾控预防控制局. 2015年全国法定传染病疫情概况[EB/OL]. http://www.nhc.gov.cn/jkj/s6873/201602/b9217ba14e17452aad9e45a5bcce6b65.shtml.
[42]	HUGHES SA, WEDEMEYER H, HARRISON PM. Hepatitis delta virus[J]. Lancet, 2011, 378(9785): 73-85. DOI: 10.1016/S0140-6736(10)61931-9.
[43]	MIAO Z, ZHANG S, OU X, et al. Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection[J]. J Infect Dis, 2020, 221(10): 1677-1687. DOI: 10.1093/infdis/jiz633.
[44]	WU S, ZHANG Y, TANG Y, et al. Molecular epidemiology and clinical characteristics of hepatitis delta virus (HDV) infected patients with elevated transaminases in Shanghai, China[J]. BMC Infect Dis, 2020, 20(1): 565. DOI: 10.1186/s12879-020-05275-1.
[45]	LIU YM, GUO XP, ZHANG HM, et al. An investigation of hepatitis D virus infection among patients with chronic hepatitis B virus infection in some regions of China[J]. J Clin Hepatol, 2023, 39(4): 795-803. DOI: 10.3969/j.issn.1001-5256.2023.04.009. 刘玉梅, 郭小平, 张慧敏, 等. 我国部分地区慢性HBV感染者HDV感染情况调查[J]. 临床肝胆病杂志, 2023, 39(4): 795-803. DOI: 10.3969/j.issn.1001-5256.2023.04.009.
[46]	ROGGENBACH I, CHI X, LEMPP FA, et al. HDV seroprevalence in HBsAg-positive patients in China occurs in hotspots and is not associated with HCV mono-infection[J]. Viruses, 2021, 13(9): 1799. DOI: 10.3390/v13091799.
[47]	DA BL, HELLER T, KOH C. Hepatitis D infection: from initial discovery to current investigational therapies[J]. Gastroenterol Rep (Oxf), 2019, 7(4): 231-245. DOI: 10.1093/gastro/goz023.
[48]	XUE F, WEI L. Summary for hepatitis D research reports from EASL 2022[J]. Chin J Hepatol, 2022, 30(10): 1120-1123. DOI: 10.3760/cma.j.cn501113-20221019-00500. 薛峰, 魏来. 2022年欧洲肝病学会年会关于慢性丁型肝炎研究的进展[J]. 中华肝脏病杂志, 2022, 30(10): 1120-1123. DOI: 10.3760/cma.j.cn501113-20221019-00500.
[49]	GU XH, LI QF, WANG YM. Analysis of clinical characteristics of 507 cases of Hepatitis with HDV infection[J]. J Third Milit Med Univ, 2000, 22(2): 185-188. DOI: 10.3321/j.issn:1000-5404.2000.02.026. 顾小红, 李奇芬, 王宇明. 507例HDV感染肝炎患者临床研究[J]. 第三军医大学学报, 2000, 22(2): 185-188. DOI: 10.3321/j.issn:1000-5404.2000.02.026.
[50]	ZHAO GR, HUANG XX, ZHAO DT. Prevalence of hepatitis D in China[J]. J Clin Hepatol, 1995, 11(4): 179-180. http://lcgdbzz.org/article/id/LCGD504.004 赵国瑞, 黄宪希, 赵大同. 国内丁型肝炎流行概况[J]. 临床肝胆病杂志, 1995, 11(4): 179-180. http://lcgdbzz.org/article/id/LCGD504.004
[51]	LIU HM, TAN ZX, YANG J, et al. Prevalence and clinical characteristics of hepatitis D in Southwest of China[J]. Chin J Exp Clin Virol, 2022, 36(1): 85-91. DOI: 10.3760/cma.j.cn112866-20210611-00096. 刘慧敏, 谭朝霞, 杨京, 等. 中国西南地区丁型肝炎的流行状况与临床特征分析[J]. 中华实验和临床病毒学杂志, 2022, 36(1): 85-91. DOI: 10.3760/cma.j.cn112866-20210611-00096.
[52]	ZHOU HB, REN F, CHEN Y, et al. HDV infection in chronic hepatitis B virus infected patients with different disease phases in China[C]. 32nd annual meeting of the Asian-Pacific Association for the Study of the Liver. Taipei, 2023.
[53]	ZHENG RJ, TANGNUER·TLF, DENG ZR, et al. Sero-epidemiological characteristics of the hepatitis D virus infection among hepatitis B virus infected-patients at a single center in Xinjiang region[J]. Chin J Hepatol, 2022, 30(10): 1044-1049. DOI: 10.3760/cma.j.cn501113-20220406-00169. 郑嵘炅, 唐努尔·塔拉甫, 邓泽润, 等. 新疆地区单中心乙型肝炎病毒感染者中丁型肝炎病毒感染的血清流行病学特点[J]. 中华肝脏病杂志, 2022, 30(10): 1044-1049. DOI: 10.3760/cma.j.cn501113-20220406-00169.
[54]	SARIN SK, KUMAR M, LAU GK, et al. Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update[J]. Hepatol Int, 2016, 10(1): 1-98. DOI: 10.1007/s12072-015-9675-4.
[55]	European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection[J]. J Hepatol, 2017, 67(2): 370-398. DOI: 10.1016/j.jhep.2017.03.021.
[56]	TERRAULT NA, LOK A, MCMAHON BJ, et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance[J]. Hepatology, 2018, 67(4): 1560-1599. DOI: 10.1002/hep.29800.
[57]	ABDRAKHMAN A, ASHIMKHANOVA A, ALMAWI WY. Effectiveness of pegylated interferon monotherapy in the treatment of chronic hepatitis D virus infection: A meta-analysis[J]. Antiviral Res, 2021, 185: 104995. DOI: 10.1016/j.antiviral.2020.104995.
[58]	YAN H, ZHONG G, XU G, et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus[J]. Elife, 2012, 1: e00049. DOI: 10.7554/eLife.00049.
[59]	KOH C, DA BL, GLENN JS. HBV/HDV coinfection: A challenge for therapeutics[J]. Clin Liver Dis, 2019, 23(3): 557-572. DOI: 10.1016/j.cld.2019.04.005.
[60]	LOUREIRO D, CASTELNAU C, TOUT I, et al. New therapies for hepatitis delta virus infection[J]. Liver Int, 2021, 41 Suppl 1: 30-37. DOI: 10.1111/liv.14838.

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Research history of hepatitis D in China

DOI: 10.3969/j.issn.1001-5256.2023.04.002

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Research history of hepatitis D in China

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