Role of tumor-associated macrophages in cholangiocarcinoma

Pinsheng HAN; Long YANG; Tao CUI; Yamin ZHANG

doi:10.3969/j.issn.1001-5256.2023.02.035

Volume 39 Issue 2

Feb. 2023

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Article Navigation > Journal of Clinical Hepatology > 2023 > 39(2): 469-473

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Role of tumor-associated macrophages in cholangiocarcinoma

DOI: 10.3969/j.issn.1001-5256.2023.02.035

Pinsheng HAN¹,
Long YANG²,
Tao CUI^{3, 4},
Yamin ZHANG^{2
,
,
,}

1.
Clinical Medical College of Tianjin Medical University, Tianjin 300070, China
2.
Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300192, China
3.
State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300000, China
4.
Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing 100730, China

Research funding:

Science and Technology Fund of Tianjin First Central Hospital (2019CL01);

CAMS Innovation Fund for Medical Sciences (2019-I2M-5-020);

Tianjin Key Training Project for 'Project + Team' (XC202030)

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Corresponding author: ZHANG Yamin, 13802122219@163.com (ORCID: 0000-0002-7175-8762)
Received Date: 2022-07-02
Accepted Date: 2022-09-05
Published Date: 2023-02-20

Abstract

Abstract

Cholangiocarcinoma (CCA) is a highly malignant biliary tumor with strong invasion and poor prognosis and is insensitive to radiotherapy and chemotherapy. Tumor-associated macrophage (TAM) is an important component of the tumor microenvironment. CCA cells recruit TAM into tumor tissue by releasing cytokines and polarize them into M2 TAM, which promotes the progression of CCA through various mechanisms such as assisting immune escape, promoting tumor cell proliferation, regulating angiogenesis, promoting tumor metastasis, and mediating immune resistance. As an emerging target of tumor immunotherapy, TAM provides new ideas for targeted therapy for CCA. This article reviews the mechanisms of TAM in promoting the progression of CCA and immunotherapy targeting TAM in recent years.
- Bile Duct Neoplasms,
- Macrophages,
- Tumor Microenvironment

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References(34)

References

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Role of tumor-associated macrophages in cholangiocarcinoma

DOI: 10.3969/j.issn.1001-5256.2023.02.035

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