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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 2
Feb.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(2): 439-443

From viral hepatitis to hepatocellular carcinoma: The role of exosomal microRNAs

DOI: 10.3969/j.issn.1001-5256.2023.02.030
  • 1.

    Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, China

  • 2.

    Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Research funding:

National Natural Science Foundation of China (82170541);

Natural Science Foundation of Beijing (7202071)

More Information
  • Corresponding author: WEI Hongshan, drwei@ccmu.edu.cn (ORCID: 0000-0001-8893-653X)
  • Received Date: 2022-06-28
  • Accepted Date: 2022-07-27
  • Published Date: 2023-02-20
    Abstract
  • Exosomes are nano-sized phospholipid bilayer vesicles containing abundant and complex biomolecules, such as DNA, mRNAs, microRNAs (miRNAs), lipids, and proteins. Exosomes can be secreted and ingested by most types of cells to transfer information through intercellular transport. After uptake by recipient cells, exosomes release bioactive substances to regulate the biological processes of recipient cells, such as promoting tumor growth and metastasis. Changes of exosomes and their contents are associated with a variety of diseases. In recent years, the role of exosomal miRNAs in the development and progression of hepatocellular carcinoma (HCC) caused by viral hepatitis has attracted wide attention, and exosomal miRNAs from different sources play different roles in this process. This article briefly reviews the research on the role of exosomal miRNAs in the development and progression of viral hepatitis-related HCC and proposes that exosomal miRNAs may be the targets for immunotherapy for HCC microenvironment.

     

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