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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2882-2886

Association between pancreatic cancer and diabetes

DOI: 10.3969/j.issn.1001-5256.2022.12.039
  • a.

    Department of Pancreatic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

  • b.

    Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

Research funding:

National Natural Science Foundation of China (82170651);

National Natural Science Foundation of China (81870442)

More Information
  • Corresponding author: WANG Weixing, sate.llite@163.com (ORCID: 0000-0002-3854-0083)
  • Received Date: 2020-07-30
  • Accepted Date: 2020-08-31
  • Published Date: 2022-12-20
    Abstract
  • Pancreatic cancer is a type of highly malignant digestive system tumor, with a 5-year overall survival rate of < 10%. In recent years, a large number of studies have shown that there is a two-way relationship between pancreatic cancer and diabetes; diabetes is not only one of the high-risk factors for pancreatic cancer, but also a paraneoplastic phenomenon caused by pancreatic cancer. Hyperglycemia and hyperinsulinemia in patients with type 2 diabetes are risk factors for pancreatic cancer, and on the contrary, pancreatic cancer cells cause the dysfunction of pancreatic β cells through autocrine or paracrine pathways and thus lead to the onset of pancreatic diabetes. This article reviews the epidemiology and pathogenesis of pancreatic cancer and the two-way relationship between pancreatic cancer and diabetes, so as to provide a reference for clinical practice.

     

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