Application of proton pump inhibitors in acute-on-chronic liver failure

Yuhao YAO; Xiao XIA; Jiaxin ZHANG; Xiaoke LI; Yong'an YE

doi:10.3969/j.issn.1001-5256.2022.12.035

Volume 38 Issue 12

Dec. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(12): 2864-2867

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Application of proton pump inhibitors in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.12.035

Yuhao YAO^{1, 2},
Xiao XIA³,
Jiaxin ZHANG^{2, 4},
Xiaoke LI^{2, 4
,
,
,},
Yong'an YE^{2, 4
,
,
,}

1.
The First Clinical Medical School, Beijing University of Chinese Medicine, Beijing 100029, China
2.
Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
3.
Department of Pneumology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
4.
Liver Diseases Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100700, China

Research funding:

National Natural Science Foundation of China (82174341);

Scientific Research Projects of National Administration of Traditional Chinese Medicine (JDZX2015300);

Major Research Project of Beijing University of Chinese Medicine (2022-JYB-ZDGG-115)

More Information

Corresponding author: LI Xiaoke, lixiaoke@vip.163.com (ORCID: 0000-0002-1775-3063); YE Yong'an, yeyongan@vip.163.com (ORCID: 0000-0001-9765-4665)
Received Date: 2022-04-20
Accepted Date: 2022-05-24
Published Date: 2022-12-20

Abstract

Abstract

Proton pump inhibitors (PPIs) are commonly used in clinical practice and are currently widely used in people with acute-on-chronic liver failure (ACLF). However, such medication is still not supported by the recommendations in the latest version of Clinical guidelines for acute-on-chronic liver failure issued by American College of Gastroenterology. With reference to the guidelines or consensus statements in China and globally and the latest research advances, this article elaborates on the indications, possible benefits, and potential risks of PPIs used in people with ACLF, in order to provide a reference for the standardized use of PPIs in the population with ACLF in clinical practice.
- Liver Failure,
- Proton Pump Inhibitors,
- Therapeutic Uses

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References(36)

References

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Application of proton pump inhibitors in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.12.035

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