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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Contents

Macrophage depletion and its application in liver injury

DOI: 10.3969/j.issn.1001-5256.2022.12.034
Research funding:

National Natural Science Foundation of China (81770612)

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  • Corresponding author: LIU Liangming, liuliangming@hotmail.com (ORCID: 0000-0001-6001-8729)
  • Received Date: 2022-04-20
  • Accepted Date: 2022-05-21
  • Published Date: 2022-12-20
  • Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathophysiological processes. Selective clearance of macrophages in vivo is a widely accepted method used to investigate whether macrophages are involved in any specific biological regulatory mechanism. Understanding the different methods and principles of macrophage depletion helps explore appropriate modeling solutions to investigate the relationship between macrophages and diseases. Hepatic macrophages play a crucial role in hepatotoxicity. This article reviews the methods of macrophage depletion and the regulatory role of macrophage depletion in liver injury and repair.

     

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