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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2846-2849

Research progress in nutritional support for liver cirrhosis patients

DOI: 10.3969/j.issn.1001-5256.2022.12.031
  • 1.

    North Sichuan Medical College, Nanchong, Sichuan 623300, China

  • 2a.

    Department of Gastroenterology, The Third People Hospital of Chengdu, Chengdu 610031, China

  • 2b.

    Department of Clinical Nutrition, The Third People Hospital of Chengdu, Chengdu 610031, China

  • 3.

    School of Medicine, Southwest Jiaotong University, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, China

Research funding:

National Natural Science Foundation of China (81700467);

The Fifth Batch of Technological Innovation R & D Project of Chengdu (2021-YF05-00585-SN);

Sichuan Provincial Key R & D Project (2022YFS0340);

Chengdu Health Commission Research Project (202103031154)

More Information
  • Corresponding author: WU Liping, wuliping1985116@163.com (ORCID: 0000-0002-1615-3832)
  • Received Date: 2022-04-22
  • Accepted Date: 2022-08-02
  • Published Date: 2022-12-20
    Abstract
  • Malnutrition in liver cirrhosis is associated with ascites, hepatic encephalopathy, infection, and other complications even death. To date, the hazard and disease burden of malnutrition in cirrhosis patients have been severely underestimated. This review summarized the most recent advancement in the field and discussed the techniques and methodologies in detection and evaluation of malnutrition in cirrhosis patients, nutritional support therapy, and future research directions and clinical care of the patients.

     

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    • References(40)
  • [1]
    JAVAID N, KHAN Z, ALI MA, et al. Evaluating the impact of early nutritional assessment and intervention in hospitalized liver cirrhosis patients[J]. Arq Gastroenterol, 2022, 59(1): 22-28. DOI: 10.1590/S0004-2803.202200001-05.
    [2]
    KOULENTAKI M, DRYGIANNAKIS I, MANTAKA A, et al. Nutritional assessment of greek liver cirrhosis patients: mini nutritional assessment predicts mortality[J]. Healthcare (Basel), 2022, 10(5): 859. DOI: 10.3390/healthcare10050859.
    [3]
    BELLANTI F, LO BUGLIO A, QUIETE S, et al. Comparison of three nutritional screening tools with the new glim criteria for malnutrition and association with sarcopenia in hospitalized older patients[J]. J Clin Med, 2020, 9(6): 1898. DOI: 10.3390/jcm9061898.
    [4]
    MAHARSHI S, SHARMA BC, SRIVASTAVA S. Malnutrition in cirrhosis increases morbidity and mortality[J]. J Gastroenterol Hepatol, 2015, 30(10): 1507-1513. DOI: 10.1111/jgh.12999.
    [5]
    Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Gastroenterology, Chinese Medical Association. Clinical guidelines on nutrition in end-stage liver disease[J]. J Clin Hepatol, 2019, 35(6): 1222-1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.

    中华医学会肝病学分会, 中华医学会消化病学分会. 终末期肝病临床营养指南[J]. 临床肝胆病杂志, 2019, 35(6): 1222-1230. DOI: 10.3969/j.issn.1001-5256.2019.06.010.
    [6]
    PALMER LB, KUFTINEC G, PEARLMAN M, et al. Nutrition in cirrhosis[J]. Curr Gastroenterol Rep, 2019, 21(8): 38. DOI: 10.1007/s11894-019-0706-5.
    [7]
    KONDRUP J. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials[J]. Clin Nutr, 2003, 22(3): 321-336. DOI: 10.1016/s0261-5614(02)00214-5.
    [8]
    MCFARLANE M, HAMMOND C, ROPER T, et al. Comparing assessment tools for detecting undernutrition in patients with liver cirrhosis[J]. Clin Nutr ESPEN, 2018, 23: 156-161. DOI: 10.1016/j.clnesp.2017.10.009.
    [9]
    DHALIWAL A, TOWEY J, LORD JM, et al. Nutrition in liver cirrhosis: a case-based overview[J]. Frontline Gastroenterol, 2020, 11(2): 155-161. DOI: 10.1136/flgastro-2018-101121.
    [10]
    BORHOFEN SM, GERNER C, LEHMANN J, et al. The royal free hospital-nutritional prioritizing tool is an independent predictor of deterioration of liver function and survival in cirrhosis[J]. Dig Dis Sci, 2016, 61(6): 1735-1743. DOI: 10.1007/s10620-015-4015-z.
    [11]
    AMODIO P, BEMEUR C, BUTTERWORTH R, et al. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus[J]. Hepatology, 2013, 58(1): 325-336. DOI: 10.1002/hep.26370.
    [12]
    WU Y, ZHU Y, FENG Y, et al. Royal Free Hospital-Nutritional Prioritizing Tool improves the prediction of malnutrition risk outcomes in liver cirrhosis patients compared with Nutritional Risk Screening 2002[J]. Br J Nutr, 2020, 124(12): 1293-1302. DOI: 10.1017/S0007114520002366.
    [13]
    European Association for the Study of the Liver. EASL Clinical Practice Guidelines on nutrition in chronic liver disease[J]. J Hepatol, 2019, 70(1): 172-193. DOI: 10.1016/j.jhep.2018.06.024.
    [14]
    DAǦ Z, KÖSEOǦLU H, KEKILLI M. The use of prealbumin as a predictor of malnutrition in cirrhotic patients and the effect of nutritional support in patients with low prealbumin levels[J]. Turk J Med Sci, 2020, 50(2): 398-404. DOI: 10.3906/sag-1910-27.
    [15]
    BAKSHI N, SINGH K. Nutrition assessment in patients undergoing liver transplant[J]. Indian J Crit Care Med, 2014, 18(10): 672-681. DOI: 10.4103/0972-5229.142177.
    [16]
    CICHOŻ-LACH H, MICHALAK A. A Comprehensive review of bioelectrical impedance analysis and other methods in the assessment of nutritional status in patients with liver cirrhosis[J]. Gastroenterol Res Pract, 2017, 2017: 6765856. DOI: 10.1155/2017/6765856.
    [17]
    BELARMINO G, GONZALEZ MC, TORRINHAS RS, et al. Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis[J]. World J Hepatol, 2017, 9(7): 401-408. DOI: 10.4254/wjh.v9.i7.401.
    [18]
    HOPKINSON J. Psychosocial support in cancer cachexia syndrome: the evidence for supported self-management of eating problems during radiotherapy or chemotherapy treatment[J]. Asia Pac J Oncol Nurs, 2018, 5(4): 358-368. DOI: 10.4103/apjon.apjon_12_18.
    [19]
    LAI JC, TANDON P, BERNAL W, et al. Malnutrition, frailty, and sarcopenia in patients with cirrhosis: 2021 practice guidance by the American Association for the Study of Liver Diseases[J]. Hepatology, 2021, 74(3): 1611-1644. DOI: 10.1002/hep.32049.
    [20]
    PLAUTH M, BERNAL W, DASARATHY S, et al. ESPEN guideline on clinical nutrition in liver disease[J]. Clin Nutr, 2019, 38(2): 485-521. DOI: 10.1016/j.clnu.2018.12.022.
    [21]
    WANG R, ZHANG YG, LI QQ, et al. Evaluation value of area index of the third lumbar psoas major muscle in nutritional status and prognosis of patients with cirrhosis[J]. Clin J Med Offic, 2022, 50(7): 729-732. DOI: 10.16680/j.1671-3826.2022.07.18.

    王然, 张永国, 李谦谦, 等. 第三腰椎腰大肌面积指数对肝硬化患者营养状态及预后评估价值[J]. 临床军医杂志, 2022, 50(7): 729-732. DOI: 10.16680/j.1671-3826.2022.07.18.
    [22]
    EBADI M, TANDON P, MOCTEZUMA-VELAZQUEZ C, et al. Low subcutaneous adiposity associates with higher mortality in female patients with cirrhosis[J]. J Hepatol, 2018, 69(3): 608-616. DOI: 10.1016/j.jhep.2018.04.015.
    [23]
    GEORGIOU A, PAPATHEODORIDIS GV, ALEXOPOULOU A, et al. Evaluation of the effectiveness of eight screening tools in detecting risk of malnutrition in cirrhotic patients: the KIRRHOS study[J]. Br J Nutr, 2019, 122(12): 1368-1376. DOI: 10.1017/S0007114519002277.
    [24]
    FIGUEIREDO FA, PEREZ RM, FREITAS MM, et al. Comparison of three methods of nutritional assessment in liver cirrhosis: subjective global assessment, traditional nutritional parameters, and body composition analysis[J]. J Gastroenterol, 2006, 41(5): 476-482. DOI: 10.1007/s00535-006-1794-1.
    [25]
    MORGAN MY, MADDEN AM, SOULSBY CT, et al. Derivation and validation of a new global method for assessing nutritional status in patients with cirrhosis[J]. Hepatology, 2006, 44(4): 823-835. DOI: 10.1002/hep.21358.
    [26]
    PERUMPAIL BJ, LI AA, CHOLANKERIL G, et al. Optimizing the nutritional support of adult patients in the setting of cirrhosis[J]. Nutrients, 2017, 9(10): 1114. DOI: 10.3390/nu9101114.
    [27]
    BISCHOFF SC, BERNAL W, DASARATHY S, et al. ESPEN practical guideline: Clinical nutrition in liver disease[J]. Clin Nutr, 2020, 39(12): 3533-3562. DOI: 10.1016/j.clnu.2020.09.001.
    [28]
    FIALLA AD, ISRAELSEN M, HAMBERG O, et al. Nutritional therapy in cirrhosis or alcoholic hepatitis: a systematic review and meta-analysis[J]. Liver Int, 2015, 35(9): 2072-2078. DOI: 10.1111/liv.12798.
    [29]
    HOU W, WANG ZY, DONG JL, et al. Application of enteral nutrition and late evening snacks in patients with liver cirrhosis[J]. Clin Med J, 2019, 17 (4): 33-37. DOI: 10.3969/j.issn.1672-3384.2019.04.008.

    侯维, 王忠英, 董金玲, 等. 肠内营养及睡前加餐在肝硬化患者中的应用效果评价[J]. 临床药物治疗杂志, 2019, 17(4): 33-37. DOI: 10.3969/j.issn.1672-3384.2019.04.008.
    [30]
    SHERGILL R, SYED W, RIZVI SA, et al. Nutritional support in chronic liver disease and cirrhotics[J]. World J Hepatol, 2018, 10(10): 685-694. DOI: 10.4254/wjh.v10.i10.685.
    [31]
    SINGER P, BLASER AR, BERGER MM, et al. ESPEN guideline on clinical nutrition in the intensive care unit[J]. Clin Nutr, 2019, 38(1): 48-79. DOI: 10.1016/j.clnu.2018.08.037.
    [32]
    BAGER P, OLESEN L, BALTZER RL, et al. Equal efficacy of gastric and jejunal tube feeding in liver cirrhosis and/or alcoholic hepatitis: a randomised controlled study[J]. Br J Nurs, 2020, 29(20): 1148-1154. DOI: 10.12968/bjon.2020.29.20.1148.
    [33]
    PLAUTH M, CABRÉ E, RIGGIO O, et al. ESPEN guidelines on enteral nutrition: liver disease[J]. Clin Nutr, 2006, 25(2): 285-294. DOI: 10.1016/j.clnu.2006.01.018.
    [34]
    PLAUTH M, CABRÉ E, CAMPILLO B, et al. ESPEN guidelines on parenteral nutrition: hepatology[J]. Clin Nutr, 2009, 28(4): 436-444. DOI: 10.1016/j.clnu.2009.04.019.
    [35]
    REINTAM BLASER A, STARKOPF J, ALHAZZANI W, et al. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines[J]. Intensive Care Med, 2017, 43(3): 380-398. DOI: 10.1007/s00134-016-4665-0.
    [36]
    ASLAM M, FAROOQ S, RIZWAN B, et al. Assessment of nutritional status of the cirrhotic patients on enteral and parenteral feeding[J]. Nutr Health, 2022, 28(1): 69-76. DOI: 10.1177/02601060211020968.
    [37]
    TAJIRI K, SHIMIZU Y. Branched-chain amino acids in liver diseases[J]. World J Gastroenterol, 2013, 19(43): 7620-7629. DOI: 10.3748/wjg.v19.i43.7620.
    [38]
    SAKAI Y, IWATA Y, ENOMOTO H, et al. Two randomized controlled studies comparing the nutritional benefits of branched-chain amino acid (BCAA) granules and a BCAA-enriched nutrient mixture for patients with esophageal varices after endoscopic treatment[J]. J Gastroenterol, 2015, 50(1): 109-118. DOI: 10.1007/s00535-014-0950-2.
    [39]
    PARK JG, TAK WY, PARK SY, et al. Effects of Branched-Chain Amino Acid (BCAA) supplementation on the progression of advanced liver disease: A Korean Nationwide, Multicenter, Prospective, Observational, Cohort Study[J]. Nutrients, 2020, 12(5): 1429. DOI: 10.3390/nu12051429.
    [40]
    LES I, DOVAL E, GARCÍA-MARTÍNEZ R, et al. Effects of branched-chain amino acids supplementation in patients with cirrhosis and a previous episode of hepatic encephalopathy: a randomized study[J]. Am J Gastroenterol, 2011, 106(6): 1081-1088. DOI: 10.1038/ajg.2011.9.
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