Clinical significance of FAT4 protein expression in pancreatic cancer

Yao ZHANG; Kai ZHANG; Chao MA

doi:10.3969/j.issn.1001-5256.2022.12.021

Volume 38 Issue 12

Dec. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(12): 2802-2806

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Clinical significance of FAT4 protein expression in pancreatic cancer

DOI: 10.3969/j.issn.1001-5256.2022.12.021

Department of Hepatopancreatobiliary Surgery, The Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou 450008, China

Research funding:

Science and Technology Key Project of Henan Province (162102310315)

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Corresponding author: MA Chao, mjc1566@sina.com (ORCID: 0000-0002-6894-1259)
Received Date: 2022-05-09
Accepted Date: 2022-06-22
Published Date: 2022-12-20

Abstract

Abstract

Objective To detect the expression of fat atypical cadherin 4 (FAT4) in pancreatic cancer tissue and para-carcinoma tissue, and explored the role of FAT4 in the pathogenesis of pancreatic cancer. Methods Pancreatic cancer tissue samples and adjacent tissue samples were collected from 79 patients who underwent radical resection in The Affiliated Cancer Hospital of Zhengzhou University from January 2015 to January 2017 and were diagnosed with pancreatic ductal adenocarcinoma based on postoperative pathology. Immunohistochemistry was used to measure the protein expression of FAT4 in pancreatic cancer tissue and adjacent tissue, and the association between FAT4 expression and clinicopathological features was analyzed. The Mann-Whitney U test was used for comparison of ranked data between groups, and the chi-square test was used for comparison of categorical data. A Spearman correlation analysis was used to investigate the correlation between variables. Results The down-regulated expression of FAT4 was detected in 72.15% (52/79) of pancreatic cancer tissue, which was significant higher than that in para-cancer tissues (21.52%, 17/79, P < 0.001). There was a significant difference in backache between the low FAT4 expression group and the high FAT4 expression group (χ²=4.115, P=0.042), and there were also significant differences in lymph node metastasis and perineural invasion between these two groups (χ²=8.743 and 4.925, P=0.003 and 0.026). TNM staging and degree of tumor differentiation were ranked variables, and the analysis of the association between these two variables and FAT4 expression based on Spearman rank correlation coefficient showed that FAT4 expression was not associated with the TNM staging and degree of tumor differentiation of pancreatic cancer (all P > 0.05). Conclusion The expression of FAT4 was significantly down-regulated in pancreatic cancer, suggesting that FAT4 may promote the invasion and infiltration of pancreatic cancer.
- Pancreatic Neoplasms,
- Immunohistochemistry,
- Pathology, Clinical

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Clinical significance of FAT4 protein expression in pancreatic cancer

DOI: 10.3969/j.issn.1001-5256.2022.12.021

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Clinical significance of FAT4 protein expression in pancreatic cancer

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