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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 12
Dec.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(12): 2774-2779

Value of 18F-FDG PET/CT, contrast-enhanced ultrasound, and their combined use in differential diagnosis of benign and malignant pancreatic lesions: A comparative study

DOI: 10.3969/j.issn.1001-5256.2022.12.017
  • a.

    Department of Nuclear Medicine, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, China

  • b.

    Department of Gynaecology and Obstetrics, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, China

  • c.

    Department of Ultrasound, Tangshan Gongren Hospital, Tangshan, Hebei, 063000, China

Research funding:

Science & Technology Program of Tangshan (19150220E)

More Information
  • Corresponding author: OUYANG Xiangliu, usouyangxl@163.com (ORCID: 0000-0001-9366-3820)
  • Received Date: 2022-05-06
  • Accepted Date: 2022-06-15
  • Published Date: 2022-12-20
    Abstract
  •   Objective  To assess the value of 18F-FDG PET/CT, contrast-enhanced ultrasound, and their combination in the differential diagnosis of benign and malignant pancreatic lesions.  Methods  A retrospective analysis was performed on patients with pancreatic lesions who underwent18F-FDG PET/CT and contrast-enhanced ultrasound who were admitted to Tangshan Gongren Hospital from January 2015 to December 2020. The imaging results were confirmed by pathology examination to evaluate diagnostic sensitivity, specificity, accuracy, positive and negative predictive value. The t-test was used for comparison of continuous data between two groups, and the chi-square test was used for comparison of categorical data between groups.  Results  There were 83 malignant lesions and 25 benign lesions in 108 patients. The sensitivity, specificity, accuracy, positive and negative predictive value were 86.75%, 80.00%, 85.19%, 93.51% and 64.52% for 18F-FDG PET/CT; and 69.88%, 76.00%, 71.30%, 90.63% and 43.18% for contrast-enhanced ultrasound, respectively. The two methods differed significantly in sensitivity and accuracy (all P < 0.05), but not in specificity, negative and positive predictive value (all P > 0.05). When combined with the contrast-enhanced ultrasound, 18F-FDG PET/CT had an increased sensitivity, specificity, accuracy, positive and negative predictive value of 90.36%, 84.00%, 88.89%, 94.94% and 72.41%, respectively, though this was not statistically significant due to the increased signal of blood supply in the lesions.  Conclusion  18F-FDG PET/CT has a better performance than contrast-enhanced ultrasound in the differential diagnosis of benign and malignant pancreatic lesions, and their combination can improve the diagnostic value.

     

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