Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease

Lei MA; Anhua HAO; Xinxin HU; Zhenzhen ZHAO; Lin ZHOU; Yongning XIN

doi:10.3969/j.issn.1001-5256.2022.12.009

Volume 38 Issue 12

Dec. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(12): 2723-2727

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Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2022.12.009

1.
Department of Infectious Diseases, Qingdao Chengyang District People's Hospital, Qingdao, Shandong 266109, China
2a.
Clinical Research Center, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, Shandong 266071, China
2b.
Department of Infectious Diseases, Qingdao Municipal Hospital affiliated to Qingdao University, Qingdao, Shandong 266071, China

Research funding:

National Natural Science Foundation of China (32171277)

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Corresponding author: XIN Yongning, xinyongning@163.com (ORCID: 0000-0002-3692-7655)
Received Date: 2022-05-24
Accepted Date: 2022-06-28
Published Date: 2022-12-20

Abstract

Abstract

Objective To investigate the relationship between Fat Mass- and obesity-associated gene (FTO) polymorphisms and the susceptibility of non-alcohol-related fatty liver disease (NAFLD) in a Han population from Qingdao region of China. Methods A total of 119 NAFLD patients were recruited from Qingdao Municipal Hospital and Chengyang District People's Hospital and 187 control individuals who received annual physical examination were also included. Their clinicopathological information and study questionnaire were collected. Their fasting venous blood was extracted for biochemical analyses and FTO polymorphism genotyping using the polymerase chain reaction combined with DNA sequencing. The data were statistically assessed. Results The data showed statistically significant differences in age, BMI, ALT, GGT, TG and Bil between NAFLD patients and normal controls (all P < 0.05). FTO polymorphism genotyping data showed three genotypes of FTO rs1421085 (TT, CT, and CC), rs8050136 (TT, CT, and CC) and rs9939609 (TT, AT, AA). However, there was no statistical difference in both allele frequency and genotype of FTO rs1421085, rs9939609, and rs8050136 between NAFLD and controls (all P > 0.05) and there was also no statistical difference in clinical parameters among these genotype carriers (all P > 0.05). Conclusion NAFLD patients showed significantly statistical differences in age, BMI, ALT, GGT, TG, and BIL vs. those of normal controls. However, this study did not find any association of FTO rs1421085, rs9939609, and rs8050136 polymorphisms with NAFLD susceptibility in this Qingdao region of Han Chinese population.
- Non-alcoholic Fatty Liver Disease,
- Genome,
- Polymorphism, Single Nucleotide

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Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2022.12.009

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Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease

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