Regulation of hepatocyte polarity

Yuanpeng MAO; Hongshan WEI

doi:10.3969/j.issn.1001-5256.2022.11.043

Volume 38 Issue 11

Nov. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(11): 2654-2658

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Regulation of hepatocyte polarity

DOI: 10.3969/j.issn.1001-5256.2022.11.043

Yuanpeng MAO¹,
Hongshan WEI^{1, 2
,
,
,}

1.
Department of Gastroenterology, Peking University Ditan Teaching Hospital, Beijing 100015, China
2.
Department of Gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China

Research funding:

The Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals (XXZ0404);

Natural Science Foundation of Beijing (7202071);

National Natural Science Foundation of China (82170541)

More Information

Corresponding author: WEI Hongshan, drwei@ccmu.edu.cn(ORCID: 0000-0001-8893-653X)
Received Date: 2022-03-15
Accepted Date: 2022-04-25
Published Date: 2022-11-20

Abstract

Abstract

Hepatocytes are highly polarized cells, and the establishment and maintenance of hepatocyte polarity are critical for the various functions of hepatocytes. The dynamic stability of hepatocyte polarity is associated with various factors including intercellular junctions, polarity complex proteins, and several signaling pathways. Abnormal hepatocyte function is often observed when polarity gets destroyed, which may eventually lead to various liver diseases. At present, there are still a few studies on the regulation of hepatocyte polarity, and many key factors have not been fully elucidated. This article briefly introduces the recent research advances in the regulation of hepatocyte polarity.
- Liver Diseases,
- Hepatocytes,
- Cell Polarity

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References(47)

References

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Regulation of hepatocyte polarity

DOI: 10.3969/j.issn.1001-5256.2022.11.043

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