Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

Yue LIANG; Yonghong HU; Wei LIU; Yongping MU; Jiamei CHEN; Ping LIU

doi:10.3969/j.issn.1001-5256.2022.11.041

Volume 38 Issue 11

Nov. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(11): 2643-2648

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Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

DOI: 10.3969/j.issn.1001-5256.2022.11.041

Yue LIANG^{1, 2},
Yonghong HU^{1, 2},
Wei LIU^{1, 2},
Yongping MU^{1, 2},
Jiamei CHEN^{1, 2
,
,
,},
Ping LIU^{1, 2, 3
,
,
,}

1.
Institute of Liver Diseases, Shanghai Institute of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2.
Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Medicine, Shanghai 201203, China
3.
Shanghai Advanced Base of Chemistry and Biology of Traditional Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Research funding:

Key Project of National Natural Science Foundation of China (82130120);

General Project of National Natural Science Foundation of China (81973613);

China Postdoctoral Science Foundation (2021M702218)

More Information

Corresponding author: CHEN Jiamei, cjm0102@126.com(ORCID: 0000-0001-9808-9610); LIU Ping, liuliver@vip.sina.com(ORCID: 0000-0002-6152-4508)
Received Date: 2022-04-15
Accepted Date: 2022-07-14
Published Date: 2022-11-20

Abstract

Abstract

End-stage liver disease is the late stage of various acute and chronic liver diseases with high mortality and seriously threatens people's health. Liver transplantation is currently an effective treatment method for this disease, but its clinical application is greatly limited by the factors such as shortage of donors and high costs. In recent years, clinical and basic studies have shown that bone marrow mesenchymal stem cell and its exosomes have good clinical application prospects in the treatment of end-stage liver disease. This article reviews the mechanism of action and clinical application of bone marrow mesenchymal stem cell and its exosomes in the treatment of end-stage liver disease, so as to provide a reference for further research.
- End-Stage Liver Disease,
- Mesenchymal Stem Cells,
- Exosomes,
- Therapeutics

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References(51)

References

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Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

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Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

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