Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

Mengkui HAN; Jin LI; Xiaohua YANG

doi:10.3969/j.issn.1001-5256.2022.11.037

Volume 38 Issue 11

Nov. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(11): 2621-2626

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Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.11.037

Mengkui HAN¹,
Jin LI²,
Xiaohua YANG^{1
,
,
,}

1.
Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215031, China
2.
Department of Clinical Laboratory, the Fifth People's Hospital of Suzhou, Suzhou, Jiangsu 215131, China

Research funding:

National Natural Science Foundation of China (81902054);

Science and Education Project of Suzhou (kjxw2018045);

Science and Technology Development Plan of Suzhou (SKJYD2021136);

Clinical Medicine Research Foundation of Yili (yl2021lh04)

More Information

Corresponding author: YANG Xiaohua, yxiaohua2022@163.com(ORCID: 0000-0002-1767-5499)
Received Date: 2022-04-03
Accepted Date: 2022-06-22
Published Date: 2022-11-20

Abstract

Abstract

As the key immune cells in tumor immune microenvironment, T lymphocytes can affect the proliferation and migration of hepatocellular carcinoma (HCC) cells and control tumor progression through the secretion of cytokines, cytotoxic enzymes (perforin, granzyme B), and other pathways. At the same time, immune cells such as dendritic cells and myeloid-derived suppressor cells in tumor immune microenvironment can regulate the immune function of different T cell subsets through various pathways. This article summarizes the influence of common immune cells in tumor immune microenvironment on the function of T lymphocytes and the mechanism of action of key signaling pathways associated with the functional regulation of T lymphocytes in HCC, so as to provide ideas and clues for developing better therapeutic strategies for HCC.
- Carcinoma, Hepatocellular,
- T Lymphocyte,
- Immune Microenvironment,
- Immunotherapy

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References(50)

References

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Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.11.037

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Function and regulatory mechanism of T lymphocytes in tumor immune microenvironment of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.11.037

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