Prognostic value of KRAS mutations in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization

Xuchu LIU; Shiyun QIN; Lijun CHEN; Juan CHEN; Xiaoguang YOU

doi:10.3969/j.issn.1001-5256.2022.11.015

Volume 38 Issue 11

Nov. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2022 > 38(11): 2514-2519

PDF( 2594 KB)

Prognostic value of KRAS mutations in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization

DOI: 10.3969/j.issn.1001-5256.2022.11.015

Xuchu LIU^{1a
,
,
,},
Shiyun QIN^1a,
Lijun CHEN^1a,
Juan CHEN^1b,
Xiaoguang YOU²

1a.
Tumor Treatment Center, Sanya Central Hospital, The Third People's Hospital of Hainan Province, Sanya, Hainan 572000, China
1b.
Department of Pharmacy, Sanya Central Hospital, The Third People's Hospital of Hainan Province, Sanya, Hainan 572000, China
2.
Department of Radiology, the First Affiliated Hospital of Hainan Medical College, Haikou 570102, China

Research funding:

Key R&D Technology Development Projects in Hainan Province (SQ2019KJHZ0073)

More Information

Corresponding author: LIU Xuchu, 273286268@qq.com(ORCID: 0000-0002-2868-3574)
Received Date: 2022-04-12
Accepted Date: 2022-06-25
Published Date: 2022-11-20

Abstract

Abstract

Objective To assess the prognostic value of KRAS mutation in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization (TACE). Methods Ninety-seven patients with advanced primary liver cancer who received TACE treatment in The Third People's hospital from April 2017 to May 2020 were included. The mutation status of KRAS was detected, and its relationship with the prognosis of TACE was investigated. The t-test was used for comparison of continuous data between two groups, and the chi-square test was used for comparison of categorical data between two groups. Survival analysis was performed using Kaplan-Meier survival curve and compared using Log-rank test. Cox regression analysis was performed to identify the prognostic factors. Results Among 97 patients with advanced liver cancer, KRAS mutations were detected in 34 patients (35.05%), including 21 patients with codon 12 mutation (61.76%) and 13 patients with codon 13 mutation (38.24%). KRAS mutation was associated with liver cirrhosis, intrahepatic metastasis and the number of tumors (χ²=0.035, 3.965, and 6.593, all P < 0.05). Survival analysis showed that the progression free survival and overall survival were significantly longer in KRAS wild-type patients than in KRAS mutant patients (χ²=4.465 and 4.280, all P < 0.05). Multivariate Cox analysis revealed that KRAS mutation, intrahepatic metastasis, number of tumors and BCLC stage were important factors affecting the overall survival and prognosis of patients (all P < 0.05). Conclusion KRAS mutation is common in patients with advanced primary liver cancer and is closely associated with a poor prognosis after TACE. It may become a potential indicator of clinical prognosis.
- Liver Neoplasms,
- Genes,
- Chemoembolization, Therapeutic,
- Prognosis

FullText(HTML)

References(21)

References

[1]	LI X, RAMADORI P, PFISTER D, et al. The immunological and metabolic landscape in primary and metastatic liver cancer[J]. Nat Rev Cancer, 2021, 21(9): 541-557. DOI: 10.1038/s41568-021-00383-9.
[2]	YU SX, ZHOU WP. Progress and hot spots of comprehensive treatment for primary liver cancer[J]. Chin J Dig Surg, 2021, 20(2): 163-170. DOI: 10.3760/cma.j.cn115610-20201211-00776. 袁声贤, 周伟平. 原发性肝癌综合治疗的进展和热点[J]. 中华消化外科杂志, 2021, 20(2): 163-170. DOI: 10.3760/cma.j.cn115610-20201211-00776.
[3]	LIU CX, CHANG K, NA WL, et al. Role of differential expression and regulatory mechanism of miR-152-3 p target proteins in the recurrence of hepa-tocellular carcinoma[J]. J Clin Hepatol, 2021, 37(2): 364-369. DOI: 10.3969/j.issn.1001-5256.2021.02.023. 刘晨霞, 常凯, 那琬琳, 等. miR-152-3p靶蛋白差异表达及调控机制在肝癌复发中的作用[J]. 临床肝胆病杂志, 2021, 37(2): 364-369. DOI: 10.3969/j.issn.1001-5256.2021.02.023.
[4]	BLACKBURN H, WEST S. Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer[J]. Cancer Nurs, 2016, 39(5): E1-E18. DOI: 10.1097/NCC.0000000000000302.
[5]	CHENG YR, YAN D, YANG JD, et al. Effect of hepatic artery chemoembolization combined with sorafenib in the treatment of primary liver cancer and its influence on patients' immune function[J]. Clin J Med Offic, 2021, 49(3): 290-291. DOI: 10.16680/j.1671-3826.2021.03.16. 程瑜蓉, 严冬, 杨建东, 等. 肝动脉栓塞化疗联合索拉非尼在原发性肝癌治疗中应用效果及对患者免疫功能影响[J]. 临床军医杂志, 2021, 49(3): 290-291. DOI: 10.16680/j.1671-3826.2021.03.16.
[6]	RECK M, MOK T, NISHIO M, et al. Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial[J]. Lancet Respir Med, 2019, 7(5): 387-401. DOI: 10.1016/S2213-2600(19)30084-0.
[7]	CUI FQ, LI T, WANG Z, et al. A pilot study on cetuximab and KRAS gene mutation in treatment of patients with primary liver can-cer[J]. J Prac Hepatol, 2019, 22(4): 565-568. DOI: 10.3969/j.issn.1672-5069.2019.04.029. 崔发强, 李涛, 王铮, 等. 原发性肝癌患者外周血KRAS基因水平及其对西妥昔单克隆抗体治疗疗效的影响[J]. 实用肝脏病杂志, 2019, 22(4): 565-568. DOI: 10.3969/j.issn.1672-5069.2019.04.029.
[8]	PAN CF, ZHAO SK, LI Y, et al. Mutation study of related genes in non-small cell lung cancer drug targeting sites[J]. Hainan Med J, 2018, 29(19): 2696-2698. DOI: 10.3969/j.issn.1003-6350.2018.19.009. 潘长芳, 赵胜科, 李洋, 等. 非小细胞肺癌药物靶向位点的相关基因突变研究[J]. 海南医学, 2018, 29(19): 2696-2698. DOI: 10.3969/j.issn.1003-6350.2018.19.009.
[9]	WU ST. Application of contrast-enhanced CT Scan in curative effect evaluation of primary hepatocellular carcinoma after TACE[J]. Chin J CT and MRI, 2022, 20(3): 91-93. DOI: 10.3969/j.issn.1672-5131.2022.03.030. 吴水天. CT增强扫描在评估原发性肝细胞肝癌TACE术后疗效中的应用[J]. 中国CT和MRI杂志, 2022, 20(3): 91-93. DOI: 10.3969/j.issn.1672-5131.2022.03.030.
[10]	KIM D, LEE JH, MOON H, et al. Development and evaluation of an ultrasound-triggered microbubble combined transarterial chemoembolization (TACE) formulation on rabbit VX2 liver cancer model[J]. Theranostics, 2021, 11(1): 79-92. DOI: 10.7150/thno.45348.
[11]	CHEN XW, JIANG JW, LIN FH. Longdan xiegan decoction in the treatment of embolism syndrome after interventional therapy on primary hepatocellular carcinoma[J]. J Nangjing Univ Tradit Chin Med, 2016, 32(3): 224-228. DOI: 10.14148/j.issn.1672-0482.2016.0224. 陈学武, 姜靖雯, 林福煌. 龙胆泻肝汤治疗原发性肝癌TACE术后栓塞综合征的疗效观察[J]. 南京中医药大学学报, 2016, 32(3): 224-228. DOI: 10.14148/j.issn.1672-0482.2016.0224.
[12]	YOU GM, JING BL, PAN Q, et al. Compression hemostasis with Shunlin arterial hemostatic dressing for patients with hepatocellular carcinoma after transcatheter arterial chemoembolization: its clinical application and efficacy[J]. J Intervent Radiol, 2021, 30(5): 519-522. DOI: 10.3969/j.issn.1008-794X.2021.05.021. 尤国美, 经碧玲, 潘琴, 等. 瞬灵动脉止血敷料压迫止血在肝癌TACE患者的临床应用与效果研究[J]. 介入放射学杂志, 2021, 30(5): 519-522. DOI: 10.3969/j.issn.1008-794X.2021.05.021.
[13]	LUO Y, JIANG Y. Comparison of efficiency of TACE plus HIFU and TACE alone on patients with primary liver cancer[J]. J Coll Physicians Surg Pak, 2019, 29(5): 414-417. DOI: 10.29271/jcpsp.2019.05.414.
[14]	VOGL TJ, MARKO C, LANGENBACH MC, et al. Transarterial chemoembolization of colorectal cancer liver metastasis: improved tumor response by DSM-TACE versus conventional TACE, a prospective, randomized, single-center trial[J]. Eur Radiol, 2021, 31(4): 2242-2251. DOI: 10.1007/s00330-020-07253-2.
[15]	ZHANG X, ZHOU J, ZHU DD, et al. CalliSpheres^® drug-eluting beads (DEB) transarterial chemoembolization (TACE) is equally efficient and safe in liver cancer patients with different times of previous conventional TACE treatments: a result from CTILC study[J]. Clin Transl Oncol, 2019, 21(2): 167-177. DOI: 10.1007/s12094-018-1902-8.
[16]	AARTS BM, MUÑOZ F, WILDIERS H, et al. Intra-arterial therapies for liver metastatic breast cancer: a systematic review and meta-analysis[J]. Cardiovasc Intervent Radiol, 2021, 44(12): 1868-1882. DOI: 10.1007/s00270-021-02906-1.
[17]	SUN ZQ, JIANG CY, LI BP, et al. Clinical efficacy and adverse reactions of TACE combined with different doses of apatinib in the treatment of advanced liver cancer[J]. Chin J Gerontol, 2022, 42(3): 557-560. DOI: 10.3969/j.issn.1005-9202.2022.03.014. 孙志强, 姜成毅, 李佰萍, 等. TACE联合不同剂量阿帕替尼治疗中晚期肝癌的临床疗效及不良反应[J]. 中国老年学杂志, 2022, 42(3): 557-560. DOI: 10.3969/j.issn.1005-9202.2022.03.014.
[18]	HUANG CS, YU W, WANG Q, et al. Clinical efficacy of sorafenib and TACE for primary liver cancer and its effect on bFGF and VEGF level[J]. Pract J Cancer, 2017, 32(6): 943-945. DOI: 10.3969/j.issn.1001-5930.2017.06.021 黄长山, 余伟, 王谦, 等. 索拉菲尼与TACE联合治疗原发性肝癌的临床效果及对bFGF、VEGF水平的影响[J]. 实用癌症杂志, 2017, 32(6): 943-945. DOI: 10.3969/j.issn.1001-5930.2017.06.021.
[19]	YE PL, JIA HY, PENG L. Mechanism of action of GP73 in the regulation of liver cancer: An analysis based on transcriptome sequencing[J]. J Clin Hepatol, 2021, 37(8): 1861-1866. DOI: 10.3969/j.issn.1001-5256.2021.08.022. 叶佩灵, 嘉红云, 彭亮. 转录组测序分析高尔基体蛋白73参与调控肝癌的作用机制[J]. 临床肝胆病杂志, 2021, 37(8): 1861-1866. DOI: 10.3969/j.issn.1001-5256.2021.08.022.
[20]	QIN L, ZHAN Z, WEI C, et al. Hsa-circRNA-G004213 promotes cisplatin sensitivity by regulating miR-513b-5p/PRPF39 in liver cancer[J]. Mol Med Rep, 2021, 23(6): 421. DOI: 10.3892/mmr.2021.12060.
[21]	YIN XL, XU Q. The clinical significance of KRAS and BRAF oncogene mutations in hepatocellular carcinoma[J]. J Modern Oncology, 2016, 24(15): 2419-2422. DOI: 10.3969/j.issn.1672-4992.2016.15.022. 尹小兰, 许青. 原发性肝癌中KRAS及BRAF基因突变及其临床意义[J]. 现代肿瘤医学, 2016, 24(15): 2419-2422. DOI: 10.3969/j.issn.1672-4992.2016.15.022.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(3) / Tables(2)

Get Citation

PDF

XML

Article Metrics

Article views (394) PDF downloads(37)

Prognostic value of KRAS mutations in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization

DOI: 10.3969/j.issn.1001-5256.2022.11.015

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Prognostic value of KRAS mutations in patients with advanced primary liver cancer treated with transcatheter arterial chemoembolization

DOI: 10.3969/j.issn.1001-5256.2022.11.015

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content