中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 11
Nov.  2022
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Article Contents

Efficiency and safety of immune checkpoint inhibitors in cancer patients with chronic liver disease: A systematic review

DOI: 10.3969/j.issn.1001-5256.2022.11.005
Research funding:

The Sub-Subject of the Major Projects of National Science and Technology (2017ZX10203202-002-012);

The Sub-Subject of the Major Projects of National Science and Technology (2018ZX10302206-001-007);

National Natural Science Foundation of China (81870417);

National Natural Science Foundation of China (82070605)

More Information
  • Corresponding author: WANG Yan, wangyanwang@bjmu.edu.cn(ORCID: 0000-0002-8577-0527)
  • Received Date: 2022-06-19
  • Accepted Date: 2022-07-25
  • Published Date: 2022-11-20
  • Immune checkpoint inhibitors (ICIs) have recently been approved for the treatment of cancer, and the number of cancer patients with chronic liver disease (CLD) receiving ICIs is growing rapidly. However, whether CLD affects the efficiency and safety of ICIs is becoming a research focus. This review summarizes the efficiency and safety of ICIs in cancer patients with CLD, including chronic viral hepatitis, non-alcoholic fatty liver disease, autoimmune liver disease, and cirrhosis. Specifically, data on hepatitis B virus reactivation of patients with chronic hepatitis B after ICIs treatment were reviewed, which may help to perfect and standardize the guidelines of treatment and following-up for ICIs in CLD patients.

     

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