Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation

Bo YI; Xue LI; Shanhong TANG

doi:10.3969/j.issn.1001-5256.2022.09.036

Volume 38 Issue 9

Sep. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(9): 2136-2140

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Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation

DOI: 10.3969/j.issn.1001-5256.2022.09.036

Bo YI^{1, 2},
Xue LI^{2, 3},
Shanhong TANG^{2
,
,
,}

1.
Chengdu Medical College, Chengdu 610500, China
2.
Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, China
3.
School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China

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Corresponding author: TANG Shanhong, 15928956390@163.com(ORCID: 0000-0001-6652-2942)
Received Date: 2022-02-22
Accepted Date: 2022-04-28
Published Date: 2022-09-20

Abstract

Abstract

Bile acids are synthesized and catabolized by the liver, and many factors can lead to disorders in the production, secretion, and reabsorption of bile acids, thereby causing abnormal bile acid metabolism in vivo. Common predisposing factors include hepatitis, viruses, alcohol, drugs, biliary obstruction, and inheritance. It has been reported that abnormal bile acid metabolism is associated with transporter gene mutation, and in-depth studies have been conducted in China and globally. This article reviews the mechanism of abnormal bile acid metabolism caused by gene mutations and related research advances, so as to provide a new basis and new ideas for the diagnosis and treatment of such diseases.
- Bile Acids and Salts,
- Cholestasis,
- Metabolism,
- Mutation

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References

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Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation

DOI: 10.3969/j.issn.1001-5256.2022.09.036

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Research advances in the mechanism of abnormal bile acid metabolism caused by gene mutation

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