Expert consensus for clinical application of Wuling capsule(pill) in the treatment of chronic hepatitis B

Branch of Hepatobiliary Diseases, Chinese Association of Chinese Medicine

doi:10.3969/j.issn.1001-5256.2022.09.007

Volume 38 Issue 9

Sep. 2022

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Expert consensus for clinical application of Wuling capsule(pill) in the treatment of chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2022.09.007

Branch of Hepatobiliary Diseases, Chinese Association of Chinese Medicine

Received Date: 2022-08-12
Accepted Date: 2022-08-15
Published Date: 2022-09-20

Abstract

- Chronic Hepatits B,
- Drug Therapy (TCD),
- Consensus

Corresponding author: LI Xiuhui, lixiuhui2020@ccmu.edu.cn(ORCID: 0000-0002-6707-1693)

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References(35)

References

[1]	CHEN W, FANG SN, LIU JP. Recommendations for clinical evidence grading on traditional Chinese medicine based on evidence body[J]. Chin J Integr Trad West Med, 2019, 39(3): 103-109. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201903021.htm 陈薇, 方赛男, 刘建平. 基于证据体的中医药临床证据分级标准建议[J]. 中国中西医结合杂志, 2019, 39(3): 103-109. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201903021.htm
[2]	SUN L, ZHOU YX, LIAN JQ. The follow-up study on effect of the chronic viral hepatitis patients treated with Wuling capsule[J]. J Fourth Milit Med Univ, 2000, 21(7): 905. DOI: 10.3321/j.issn:1000-2790.2000.07.073 孙利, 周永兴, 连建奇. 五灵胶囊治疗慢性肝炎的临床随访观察[J]. 第四军医大学学报, 2000, 21(7): 905. DOI: 10.3321/j.issn:1000-2790.2000.07.073
[3]	SUN KW, MAO DW, LIN B, et al. Summary report on clinical efficacy and safety evaluation of Wuling capsule in the treatment of chronic hepatitis B[R]. 2005. 孙克伟, 毛德文, 林彬, 等. 五灵胶囊治疗慢性乙型病毒性肝炎临床疗效和安全性评价总结报告[R]. 2005.
[4]	WANG XZ, JIANG XR. Early hepatitis B e antigen seroconversion after lamivudine therapy in patients with chronic hepatitis B[J]. Chin J Integr Tradit West Med Liver Dis, 2001, S1: 23-25. DOI: 10.3969/j.issn.1005-0264.2001.01.015 王小众, 蒋向荣. 慢性乙型肝炎拉米夫定治疗后的HBeAg早期血清转换[J]. 中西医结合肝病杂志, 2001, S1: 23-25. DOI: 10.3969/j.issn.1005-0264.2001.01.015
[5]	ZHOU YX, YAN R, KANG WZ, et al. Therapeutic comparison of wulingwan, schisandra fruit and biphenyl dimethyl dicarboxylatre for chronic hapetitis B[J]. J Fourth Milit Med Univ, 1991, 12(6): 436-439. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY199106015.htm 周永兴, 阎荣, 康文臻, 等. 五灵丸、五味子丸和联苯双酯治疗慢性乙型肝炎的疗效比较[J]. 第四军医大学学报, 1991, 12(6): 436-439. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY199106015.htm
[6]	TIAN GZ. The therapeutic comparison of wuling pills and bifendate in treating chronic hepatitis B[J]. Chin J Inf Tradit Chin Med, 2002, 9(11): 6-7. DOI: 10.3969/j.issn.1005-5304.2002.11.004 田桂珍. 五灵丸与联苯双酯治疗慢性乙型肝炎的疗效比较[J]. 中国中医药信息杂志, 2002, 9(11): 6-7. DOI: 10.3969/j.issn.1005-5304.2002.11.004
[7]	DUAN MT, ZHOU YX, WANG SC, et al. Clinical follow-up observation of Wuling pill and bifendate in treatment of chronic hepatitis B[J]. J Fourth Milit Med Univ, 1994, 15(5): 390-392. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY405.040.htm 段满堂, 周永兴, 王胜春, 等. 五灵丸与联苯双酯治疗慢性乙型肝炎疗效的临床随访观察[J]. 第四军医大学学报, 1994, 15(5): 390-392. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY405.040.htm
[8]	SU MH, CHEN JJ. Observation on short-term curative effect of Wuling pill on 41 cases of viral hepatitis[J]. Guangxi J Prevent Med, 2004, 10(4): 232-233. DOI: 10.3969/j.issn.1673-758X.2004.04.016 苏明华, 陈进嘉. 五灵丸治疗病毒性肝炎41例短期疗效观察[J]. 广西预防医学, 2004, 10(4): 232-233. DOI: 10.3969/j.issn.1673-758X.2004.04.016
[9]	ZHOU BG. Clinical observation on 70 cases of chronic hepatitis B treated with Wuling pill[J]. Shaanxi Correspondence J Tradit Chin Med, 1999, 2: 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZY199902021.htm 周本功. 五灵丸治疗慢性乙型病毒性肝炎70例临床观察[J]. 陕西中医函授, 1999, 2: 34-35. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZY199902021.htm
[10]	ZHAO FP, FANG L. Clinical observe on Wuling pill in treating chronic hepatitis B[J]. J Tropical Dis Parasitol, 2007, 5(2): 102-103. DOI: 10.3969/j.issn.1672-2302.2007.02.011 赵凤培, 方略. 五灵丸治疗慢性乙型病毒性肝炎的临床观察[J]. 热带病与寄生虫学, 2007, 5(2): 102-103. DOI: 10.3969/j.issn.1672-2302.2007.02.011
[11]	HAO LP, ZHANG RM. Observation on curative effect of Wuling pill in treating chronic hepatitis B[J]. Chin Tradit Patent Med, 1997, 19(8): 24-26. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA199708016.htm 郝丽萍, 张瑞梅. 五灵丸治疗慢性乙型病毒性肝炎疗效观察[J]. 中成药, 1997, 19(8): 24-26. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYA199708016.htm
[12]	FANG XG. Therapeutic effect of wuling pill on 22 cases of chronic hepatitis B[J]. The Med J Ind Enterp, 2000, 13(1): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-GQYK200001078.htm 方兴根. 五灵丸治疗慢性乙型肝炎22例疗效观察[J]. 工企医刊, 2000, 13(1): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-GQYK200001078.htm
[13]	LUO GJ, PAN XY, LUO HL. Clinical observation on 30 cases of chronic hepatitis B treated with wuling pill[J]. Shanxi J Tradit Chin Med, 1993, 4: 12-13. https://www.cnki.com.cn/Article/CJFDTOTAL-SHIX199304007.htm 罗国钧, 潘秀云, 罗海琳. 五灵丸治疗慢性乙型肝炎30例疗效观察[J]. 山西中医, 1993, 4: 12-13. https://www.cnki.com.cn/Article/CJFDTOTAL-SHIX199304007.htm
[14]	LIN SL, CHEN S, WANG XH. Therapeutic effect of wuling pill on 68 cases of chronic hepatitis B[J]. J New Chin Med, 2005, 37(7): 45-46. https://www.cnki.com.cn/Article/CJFDTOTAL-REND200507024.htm 林述龙, 陈硕, 王晓华. 五灵丸治疗慢性乙型肝炎68例疗效观察[J]. 新中医, 2005, 37(7): 45-46. https://www.cnki.com.cn/Article/CJFDTOTAL-REND200507024.htm
[15]	HUANG TZ. Observation on curative effect of Wuling pill in treating chronic hepatitis B[J]. J Guiyang Coll Tradit Chin Med, 1999, 21(2): 11-12. https://www.cnki.com.cn/Article/CJFDTOTAL-GYZX199902008.htm 黄堂珍. 五灵丸治疗慢性乙型肝炎疗效观察[J]. 贵阳中医学院学报, 1999, 21(2): 11-12. https://www.cnki.com.cn/Article/CJFDTOTAL-GYZX199902008.htm
[16]	HONG DL. Observation on short-term therapeutic effect of wuling pill on chronic hepatitis B[J]. Jiangsu Med J, 1997, 23(4): 287. https://www.cnki.com.cn/Article/CJFDTOTAL-YIYA199704048.htm 洪定玲. 五灵丸治疗慢性乙型病毒性肝炎短期疗效观察[J]. 江苏医药, 1997, 23(4): 287. https://www.cnki.com.cn/Article/CJFDTOTAL-YIYA199704048.htm
[17]	ZHAO M, XIONG SS, BA QJ, et al. Clinical observation on treating chronic viral hepatitis with Wuling pill[J]. J Henan Med Coll, 1994, 29(4): 353-355. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYK404.023.htm 赵敏, 熊诗松, 巴秋菊, 等. 中药五灵丸治疗慢性病毒性肝炎临床观察[J]. 河南医科大学学报, 1994, 29(4): 353-355. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYK404.023.htm
[18]	SHI JJ, MIAO F, LIU FL. Experience of Chinese and Western medicine combined with anti-HBV Treatment[J]. World Chin J Dig, 1998, 6(S7): 482. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB1998S2774.htm 史进军, 苗范, 刘福利. 中西药结合抗乙肝病毒治疗的体会[J]. 华人消化杂志, 1998, 6(S7): 482. https://www.cnki.com.cn/Article/CJFDTOTAL-XXHB1998S2774.htm
[19]	LIU JQ, CAO LH, LU XJ, et al. Effect of entecavir combined with wuling capsules in the treatment of compensated hepatitis B cirrhosis[J]. China J Prac Med, 2021, 48(8): 116-118. DOI: 10.3760/cma.j.cn115689-20201221-06260. 刘加群, 曹立华, 鲁小杰, 等. 恩替卡韦联合五灵胶囊治疗代偿期乙型肝炎肝硬化的效果[J]. 中国实用医刊, 2021, 48(8): 116-118. DOI: 10.3760/cma.j.cn115689-20201221-06260.
[20]	ZHOU XY, LUO RQ, WAN L, et al. Clinical efficacy of Wuling Capsule combined with Entecavir for chronic hepatitis B patients[J]. J Pract Med, 2021, 37(22): 2939-2945. DOI: 10.3969/j.issn.1006-5725.2021.22.022. 周晓元, 罗润齐, 万蕾, 等. 五灵胶囊联合恩替卡韦治疗慢性乙型肝炎的临床疗效[J]. 实用医学杂志, 2021, 37(22): 2939-2945. DOI: 10.3969/j.issn.1006-5725.2021.22.022.
[21]	ZHU Y, FU M, GUO HY, et al. Curative effect of wuling capsule combined with entecavir in treatment of patients with compensatory hepatitis B cirrhosis[J]. Lingnan J Emerg Med, 2021, 26(6): 593-595. DOI: 10.3969/j.issn.1671-301X.2021.06.010. 朱莹, 付明, 郭海燕, 等. 五灵胶囊联合恩替卡韦治疗乙肝肝硬化代偿期患者疗效观察[J]. 岭南急诊医学杂志, 2021, 26(6): 593-595. DOI: 10.3969/j.issn.1671-301X.2021.06.010.
[22]	National Essential Medicine Clinical Application Guidelines and Prescription Compilation Committee. National guide for clinical application of essential drugs (Chinese Patent Medicine)[S]. Beijing: People's Medical Publishing House, 2018. 国家基本药物临床应用指南和处方集编委会. 国家基本药物临床应用指南(中成药)[S]. 北京: 人民卫生出版社, 2018.
[23]	WANG SC, HU YW, WANG JQ, et al. Test study of effective pharmacodynamic components in WuLing capsules[J]. J Fourth Milit Med Univ, 2004, 25(17): 1587-1591. DOI: 10.3321/j.issn:1000-2790.2004.17.014. 王胜春, 胡咏武, 王俊琴, 等. 五灵胶囊药效作用的有效成分[J]. 第四军医大学学报, 2004, 25(17): 1587-1591. DOI: 10.3321/j.issn:1000-2790.2004.17.014.
[24]	CHEN XL, PENG J, QIAO Y, et al. Effects of effective component of wuling capsules on the Ras/ERK, TGF-β/Smad signal pathway regulated by expression of HSC-T6 by TGF-β1-induced[J]. China Pharmacist, 2010, 13(12): 1697-1701. DOI: 10.3969/j.issn.1008-049X.2010.12.003. 陈晓莉, 彭洁, 乔逸, 等. 五灵胶囊有效成分对TGF-β1诱导HSC-T6表达Ras/ERK、TGF-β/Smad信号通路蛋白的影响[J]. 中国药师, 2010, 13(12): 1697-1701. DOI: 10.3969/j.issn.1008-049X.2010.12.003.
[25]	WANG SC, ZHAO HP, HUANGFU MJ. Pharmacokinetic of saikosaponin d in Wuling Capsules in mouse[J]. Chin Tradit Patent Med, 2005, 27(7): 809-811. DOI: 10.3969/j.issn.1001-1528.2005.07.023. 王胜春, 赵辉平, 皇甫孟君. 五灵胶囊中柴胡皂苷d在小鼠体内药代动力学研究[J]. 中成药, 2005, 27(7): 809-811. DOI: 10.3969/j.issn.1001-1528.2005.07.023.
[26]	WANG SC, HUANGFU MJ, ZHAO HP, et al. Pharmacokinetic study of schizandrin in Wuling Capsules in mice[J]. Lishizhen Med Mater Med Res, 2004, 15(8): 468-470. DOI: 10.3969/j.issn.1008-0805.2004.08.003. 王胜春, 皇甫孟军, 赵辉平, 等. 五灵胶囊中五味子乙素在小鼠体内药代动力学研究[J]. 时珍国医国药, 2004, 15(8): 468-470. DOI: 10.3969/j.issn.1008-0805.2004.08.003.
[27]	FENG ZH, ZHOU YX, WANG SC, et al. Anti-HBV effect of Wuling capsule in vitro[J]. J Fourth Milit Med Univ, 1997, 18(4): 72. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY704.024.htm 冯志华, 周永兴, 王胜春, 等. 五灵胶囊体外抗乙肝病毒的作用[J]. 第四军医大学学报, 1997, 18(4): 72. https://www.cnki.com.cn/Article/CJFDTOTAL-DSJY704.024.htm
[28]	WANG SC, HU YW, ZHAO HP. Effect of Wuling Capsule on Hepatic Injuries Induced by CCl₄、D-GlaN and LPS[J]. Pharm J Chin PLA, 2005, 21(6): 413-417. DOI: 10.3969/j.issn.1008-9926.2005.06.005. 王胜春, 胡咏武, 赵慧平. 五灵胶囊对四氯化碳D-氨基半乳糖与内毒素所致肝损伤影响[J]. 解放军药学学报, 2005, 21(6): 413-417. DOI: 10.3969/j.issn.1008-9926.2005.06.005.
[29]	JIANG YY, WANG SC, JIANG YP, et al. Efficacy of wuling capsules for experimental hepatic fibrosis in rats[J]. J Fourth Milit Med Univ, 2001, 22(3): 265-267. DOI: 10.3321/j.issn:1000-2790.2001.03.023. 江艳艳, 王胜春, 蒋永培, 等. 五灵胶囊对大鼠实验性肝纤维化的治疗作用[J]. 第四军医大学学报, 2001, 22(3): 265-267. DOI: 10.3321/j.issn:1000-2790.2001.03.023.
[30]	HU YW, WANG SC, LIU MY, et al. Effect of Wuling capsule on collagen and matrix metalloproteinase in rats with hepatic fibrosis[J]. Chin Hepatol, 2010, 15(4): 276-280. DOI: 10.3969/j.issn.1008-1704.2010.04.013. 胡咏武, 王胜春, 刘明义, 等. 五灵胶囊对肝纤维化大鼠胶原及基质金属蛋白酶的影响[J]. 肝脏, 2010, 15(4): 276-280. DOI: 10.3969/j.issn.1008-1704.2010.04.013.
[31]	ZHAO HP, WANG SC, HU YW. Effects of Wu Ling capsules on TGF-β/Smad and Ras/ERK signal pathway protein in liver tissue of liver fibrosis rats[J]. Chin J Gastroenterol Hepatol, 2009, 18(5): 392-396. DOI: 10.3969/j.issn.1006-5709.2009.05.005. 赵辉平, 王胜春, 胡咏武. 五灵胶囊对肝纤维化大鼠肝组织TGF-β/Smad及Ras/ERK信号通路蛋白的影响[J]. 胃肠病学和肝病学杂志, 2009, 18(5): 392-396. DOI: 10.3969/j.issn.1006-5709.2009.05.005.
[32]	Study Group of Clinical Pharmacology, Xijing Hospital, Fourth Military Medical University. Experimental study on acute toxicity of Wuling capsule in mice[R]. 1998. 第四军医大学西京医院临床药理基础组. 五灵胶囊对小鼠灌胃给药急性毒性试验研究[R]. 1998.
[33]	Study Group of Wuling Pills in Xijing Hospital, Fourth Military Medical University. Animal acute toxicity test data and literatures[R]. 1989. 第四军医大学西京医院五灵丸课题组. 动物急性毒性试验资料及文献资料[R]. 1989.
[34]	Study Group of Clinical Pharmacology, Fourth Military Medical University. Long-term toxicity test of Wuling capsule on rats after intragastric administration for 180 days[R]. 2000. 第四军医大学西京医院临床药理基础组. 五灵胶囊对大鼠灌胃给药180天长期毒性试验研究[R]. 2000.
[35]	Study Group of Wuling Pills in Xijing Hospital, Fourth Military Medical University. Animal long term toxicity test data and literatures[R]. 1992. 第四军医大学西京医院五灵丸课题组. 动物长期毒性试验资料及文献资料[R]. 1992.

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Expert consensus for clinical application of Wuling capsule(pill) in the treatment of chronic hepatitis B

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Expert consensus for clinical application of Wuling capsule(pill) in the treatment of chronic hepatitis B

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