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Volume 38 Issue 7
Jul.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(7): 1671-1676

Definition, prognostic assessment, and advances in the diagnosis and treatment of acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.07.041

  • Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

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  • Corresponding author: LIAN Jianqi, lianjq@fmmu.edu.cn
  • Received Date: 2022-01-04
  • Published Date: 2022-07-20
    Abstract
  • Acute-on-chronic liver failure (ACLF) is a clinical syndrome with acute decompensation of liver function on the basis of chronic liver diseases, and at present, there is still no unified definition standard for this disease in the world. ACLF is characterized by rapid progression of liver disease, multiple organ failure, and high short-term mortality. Chronic viral hepatitis and alcoholic liver disease are the most common chronic liver diseases, and infection, alcohol, and hepatotoxic drugs are the main predisposing factors for this disease, but up to 40%-50% of ACLF cases have no identifiable predisposing factors. Early identification and accurate assessment of disease conditions are crucial to ACLF patients, but there is still a lack of ideal assessment methods for early warning and accurate assessment. Currently, the main treatment methods are organ support and treatment of complications, and liver transplantation is the only treatment method that can improve prognosis; however, there are still controversies over the selection of appropriate patients and the timing of liver transplantation.

     

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