Mechanism of action of the Hippo/YAP pathway in the development and progression of liver fibrosis

Xiaolu ZHAO; Chunyan ZHANG; Xiaoyang GAO; Yuehong MA

doi:10.3969/j.issn.1001-5256.2022.07.037

Volume 38 Issue 7

Jul. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(7): 1654-1657

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Mechanism of action of the Hippo/YAP pathway in the development and progression of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.07.037

Inner Mongolia Medical University School of Basic Medicine, Hohhot 010110, China

Research funding:

National Natural Science Foundation of China (81960759);

National Natural Science Foundation of China (81560706);

Natural Science Foundation of Inner Mongolia Autonomous Region (2019MS08010);

Natural Science Foundation of Inner Mongolia Autonomous Region (2014MS0841);

Inner Mongolia Autonomous Region Grassland Talents Training Program ;

Inner Mongolia Autonomous Region Teaching Rookie Training Program ;

Inner Mongolia Medical University Zhiyuan Talent Program

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Corresponding author: MA Yuehong, myh19982002@sina.com(ORCID: 0000-0003-1414-0066)
Received Date: 2021-12-13
Accepted Date: 2022-01-13
Published Date: 2022-07-20

Abstract

Abstract

Various etiologies cause the destruction of liver microenvironment, which leads to the loss of liver structure and function and initiates the process of liver fibrosis. Hepatic stellate cells (HSCs) are mainly activated into myofibroblasts that secrete a large amount of extracellular matrix (ECM), mostly collagen. Although there have been many studies on the anti-liver fibrosis mechanism, there is still a lack of effective target drugs for clinical application, and in recent years, studies on anti-liver fibrosis have mainly focused on interventions for the advanced stage of liver fibrosis, while ignoring the specific mechanism of early-stage liver fibrosis. Recently, there have been an increasing number of studies on Hippo signaling in liver fibrosis, with a focus on the expression of the core transcription factor Yes-associated protein (YAP) in early activated HSCs and the regulation of HSC status by this pathway. This article mainly introduces the role of the Hippo/YAP pathway in the regulation of early-stage or advanced liver fibrosis and briefly describes the potential role of regulating the stable expression and nuclear translocation of the core transcription factor YAP in reversing liver fibrosis, suggesting that this pathway can provide new directions and targets for clinical treatment.
- Liver Cirrhosis,
- Hippo Pathway,
- Yes-associated Protein,
- Pathologic Processes

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References

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Mechanism of action of the Hippo/YAP pathway in the development and progression of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2022.07.037

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Mechanism of action of the Hippo/YAP pathway in the development and progression of liver fibrosis

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