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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 7
Jul.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(7): 1629-1633

Research advances in the immune pathogenesis of hepatitis E virus infection

DOI: 10.3969/j.issn.1001-5256.2022.07.032

  • Department of Gastroenterology and Hepatology, Tianjin Xiqing Hospital, Tianjin 300380, China

Research funding:

Scientific Research Fund of YouAn Medical Alliance for the Liver and Infectious Diseases (LM202019);

The Medical Treatment Combination Fund Project of Tianjin Xiqing Hospital (XQYYKLT202006)

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  • Corresponding author: LI Hai, 15202265600@163.com (ORCID: 0000-0001-9563-6842)
  • Received Date: 2021-11-21
  • Accepted Date: 2022-01-27
  • Published Date: 2022-07-20
    Abstract
  • Hepatitis E is often acute and self-limited, but immunocompromised patients (such as solid organ transplantation recipients and patients with HIV infection or blood disease) may experience chronic infection. Immune response is the key factor for the outcome of hepatitis E virus (HEV) infection, which includes innate immunity and adaptive immunity. Various studies including cell culture, animal models, and clinical trials have helped to gain a deeper understanding of the immune pathogenesis of HEV, which provided ideas for new antiviral therapies for HEV and the development of effective vaccines. This article reviews the research on the immune pathogenesis of HEV infection in recent years and discusses the prospect of HEV prevention and treatment.

     

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