Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

Tianyu CUI; Ruixia LIU; Chenghong YIN

doi:10.3969/j.issn.1001-5256.2022.05.047

Volume 38 Issue 5

May 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(5): 1198-1202

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Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.05.047

a.
Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
b.
Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China

Research funding:

Beijing Municipal Commission of Education (KM201910025007);

National Natural Science Foundation of China (81571933)

More Information

Corresponding author: YIN Chenghong, yinchh@ccmu.edu.cn(ORCID: 0000-0002-2503-3285)
Received Date: 2021-08-31
Accepted Date: 2021-10-08
Published Date: 2022-05-20

Abstract

Abstract

Abnormal activation and secretion of pancreatic enzymes in pancreatic acinar cells is one of the important pathogeneses of acute pancreatitis (AP) and can directly damage the pancreatic tissue to accelerate disease progression and induce severe AP. At present, the drugs inhibiting the abnormal activation and secretion of pancreatic enzymes tend to have an unsatisfactory effect in clinical practice, and therefore, it is of great importance to search for new therapeutic targets. This article summarizes the pathological events of abnormal activation and secretion of pancreatic enzymes (cytoplasmic calcium overload, colocalization of lysosomes and zymogen granules, organelle injury, obstructed apical secretion of trypsin, and increased basal secretion of trypsin), collects the molecular mechanisms of related events, and discusses the role of abnormal activation and secretion of pancreatic enzymes in the early stage of AP, so as to provide ideas for the development of targeted drugs in the future.
- Pancreatitis,
- Pancreatin,
- Secretory Vesicles

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References(37)

References

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Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.05.047

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Research advances in abnormal activation and secretion of pancreatic enzymes in acute pancreatitis

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