Risk factors for herb-induced liver injury

Yan YANG; Feilin GE; Qian HUANG; Rui ZENG; Xinyue ZHANG; Qin SUN

doi:10.3969/j.issn.1001-5256.2022.05.044

Volume 38 Issue 5

May 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(5): 1183-1187

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Risk factors for herb-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2022.05.044

Yan YANG^1a,
Feilin GE²,
Qian HUANG^1b,
Rui ZENG^1a,
Xinyue ZHANG^1a,
Qin SUN^{1a, 3
,
,
,}

1a.
School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
1b.
School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China
2.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
3.
Drug Research Center of Integrated Traditional Chinese and Western Medicine, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

National Natural Science Foundation of China (81704053);

National Natural Science Foundation of China (8193000309);

National Talents Training Project for Characteristic Technical Inheritance of Traditional Chinese Medicine (T20184828005);

Sichuan Provincial Department of Science and Technology Project (2021YFH0150);

Luzhou Municipal People's Government-Southwest Medical University Special Funding Project for the Introduction of High-level Talents (2017RC-002)

More Information

Corresponding author: SUN Qin, zxyjhsq@swmu.edu.cn(ORCID: 0000-0002-4624-8808)
Received Date: 2021-09-14
Accepted Date: 2021-10-25
Published Date: 2022-05-20

Abstract

Abstract

Drug-induced liver injury (DILI) is one of the common adverse drug reactions and is the main cause of withdrawal of drugs after marketing, which has attracted more and more attention of the public, and herb-induced liver injury (HILI) is a special type of DILI. In recent years, the frequent occurrence of HILI not only seriously endangers the health of patients, but also causes the controversy over the safety of traditional Chinese medicine. Therefore, this article reviews the potential risk factors for HILI from the three aspects of "patient", "drug", and "use", so as to provide a basis for the objective identification, prevention, and control of HILI and a reference for the construction of traditional Chinese medicine pharmacovigilance system represented by liver injury.
- Drugs, Chinese Herbal,
- Liver Injury,
- Risk Factors,
- Drug Safety

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References(47)

References

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Risk factors for herb-induced liver injury

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