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Volume 38 Issue 5
May  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(5): 1175-1178

Role of thymic stromal lymphopoietin in liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.05.042

  • Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China

Research funding:

National Natural Science Foundation of China (81960358)

More Information
  • Corresponding author: ZHU Jijin, zhujijin63@vip.sina.com(ORCID: 0000-0001-6419-1350)
  • Received Date: 2021-09-12
  • Accepted Date: 2021-10-27
  • Published Date: 2022-05-20
    Abstract
  • Thymic stromal lymphopoietin (TSLP) is a type I interleukin 2 family cytokine composed of four short-chain α-helix bundles and has homology with interleukin-7. TSLP plays an important role in many allergic diseases or autoimmune diseases, such as asthma, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel disease, and promotes the development of these diseases. At present, there are some reports on TSLP in liver diseases, and some studies showed that it can promote the development and progression of liver diseases, while others showed that it plays a protective role in liver diseases. This article reviews the molecular composition and biological features of TSLP and the role of TSLP in benign liver diseases and liver tumors and elaborates on the research advances in TSLP in liver diseases.

     

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