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Volume 38 Issue 5
May  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(5): 1156-1160

Role of exercise-induced autophagy in prevention and treatment of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2022.05.038

  • School of Physical Sciences, Tianjin Normal University, Tianjin 300387, China

Research funding:

National Social Science Fund of China (19ZDA353);

Youth Program of National Social Science Foundation of China (20CTY004)

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  • Corresponding author: BAI Lili, blx0305@163.com(ORCID: 0000-0002-2216-8723)
  • Received Date: 2021-08-22
  • Published Date: 2022-05-20
    Abstract
  • Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by chronic liver damage. Epidemiological surveys have shown that the incidence rate of NAFLD is increasing constantly and NAFLD has become a serious threat to human life and health. Studies have shown that autophagy dysregulation is an important pathophysiological mechanism of NAFLD, and exercise, as an important non-pharmacological treatment, can prevent and treat NAFLD by inducing autophagy, but its exact mechanism is still unclear. This article summarizes the theoretical studies and application results related to the association between autophagy and NAFLD, the effect of exercise-induced autophagy on NAFLD, and its potential molecular mechanism, in order to provide a theoretical reference for the prevention and treatment of NAFLD.

     

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