Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Minghao LIU; Sutong LIU; Lihui ZHANG; Yajiao GU; Dongfang SHANG; Zhun XIAO; Wenxia ZHAO

doi:10.3969/j.issn.1001-5256.2022.05.037

Volume 38 Issue 5

May 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(5): 1152-1155

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Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

DOI: 10.3969/j.issn.1001-5256.2022.05.037

Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81904154);

The Science and Technology Research Program of Henan Province (202102310168);

Key Research and Promotion Project of Henan Province (192102310425);

Traditional Chinese Medicine Science Research Project of Henan Province (2019JDZX2051);

Key Science and Technology Project of Henan Province (202102310495);

TCM Discipline Construction Project of Characteristic Backbone Disciplines of Henan Province (STG-ZYXKY-2020024)

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Corresponding author: ZHAO Wenxia, zhao-wenxia@163.com(ORCID: 0000-0001-6666-9469)
Received Date: 2022-01-20
Published Date: 2022-05-20

Abstract

Abstract

Ferroptosis is a type of iron-dependent cell death driven by lipid peroxidation, and its mechanism is associated with iron homeostasis imbalance, lipid peroxidation, and slC7A11-GSH-GPX4 antioxidant system. Ferroptosis plays a key role in the development and progression of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), and inhibition of ferroptosis can almost completely inhibit the development of NASH. This article reviews the research advances in the mechanism of ferroptosis and its role in NAFLD/NASH and proposes the research strategies and technical means for ferroptosis, so as to provide a reference for research on the mechanism of NAFLD/NASH.
- Non-alcoholic Fatty Liver Disease,
- Iron Death,
- Lipid Peroxidation

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References(36)

References

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Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

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Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

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