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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 3
Mar.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(3): 601-605

Comorbidity of hepatic cystic echinococcosis with HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2022.03.020
  • 1.

    Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China

  • 2a.

    Department of Oncology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China

  • 2b.

    Department of Hepatobiliary Surgery, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China

  • 3.

    NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi, Xinjiang 832000, China

Research funding:

National Natural Science Foundation of China (81860363);

Chen Xiao-Ping Foundation for the Development of Science and Technology of Hubei province (CXPJJH11900001-2019313);

Non-profit Central Research lnstitute Fund of Chinese Academy of Medical Sciences (2020-PT330-003)

More Information
  • Corresponding author: ZHANG Hongwei, zhw0108@163.com(ORCID: 0000-0002-3505-5804)
  • Received Date: 2021-08-23
  • Accepted Date: 2021-11-30
  • Published Date: 2022-03-20
    Abstract
  •   Objective  To investigate the comorbidity of hepatic cystic echinococcosis with HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma, and to lay a foundation for further research on the influence of hepatic cystic echinococcosis on HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma.  Methods  A retrospective analysis was performed for the data of 401 patients with hepatic cystic echinococcosis who were admitted to The First Affiliated Hospital of Shihezi University from 2003 to 2019, and the state of comorbidity of hepatic cystic echinococcosis with HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma was clarified. The patients with hepatic cystic echinococcosis and chronic HBV/HCV infection were selected as comorbidity group, and the patients with HBV/HCV infection alone were matched as control group. The chi-square test and the Fisher's exact test were used to analyze the state of viral infection and the disease composition of liver cirrhosis and hepatocellular carcinoma.  Results  Of all 401 patients, 38(9.5%) were included in the comorbidity group and 2(0.5%) had liver cirrhosis after HBV/HCV infection, while no patient had hepatocellular carcinoma after HBV/HCV infection. Among the patients with chronic hepatitis B virus infection in the comorbidity group, non-active HBsAg carriers accounted for 81%, HBeAg-positive chronic hepatitis B patients accounted for 9.5%, and HBeAg-negative chronic hepatitis B patients accounted for 9.5%; among the patients with hepatitis B virus infection in the control group, non-active HBsAg carriers accounted for 43%, HBeAg-positive chronic hepatitis B patients accounted for 33%, and HBeAg-negative chronic hepatitis B patients accounted for 19%, with a significant difference between the two groups (P=0.033). There was a significant difference in the HBV RNA clearance rate of the patients with HCV infection between the comorbidity group and the control group (χ2=4.447, P=0.035). In the comorbidity group, the patients with liver cirrhosis accounted for 5.2% and there were no patients with hepatocellular carcinoma, while in the control group, the patients with liver cirrhosis accounted for 18.4% and those with hepatocellular carcinoma accounted for 5.2%; the comorbidity group had significantly lower proportions than the control group (P=0.048).  Conclusion  The proportion of liver cirrhosis patients with hepatic cystic echinococcosis and HBV/HCV infection is lower than that of liver cirrhosis patients with viral hepatitis alone, and there are no cases of hepatocellular carcinoma after HBV/HCV infection. Further multicenter studies are needed to investigate the influence of hepatic cystic echinococcosis on chronic HBV/HCV infection, liver cirrhosis, and hepatocellular carcinoma.

     

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    • References(23)
  • [1]
    GAO Y, WU XW, LIU GS, et al. Clinical effect of surgery in treatment of calcified hepatic cystic echinococcosis[J]. J Clin Hepatol, 2020, 36(3): 616-619. DOI: 10.3969/j.issn.1001-5256.2020.03.029.

    高宇, 吴向未, 刘桂生, 等. 手术治疗钙化型肝细粒棘球蚴病的效果观察[J]. 临床肝胆病杂志, 2020, 36(3): 616-619. DOI: 10.3969/j.issn.1001-5256.2020.03.029.
    [2]
    HUANG D, LI R, QIU J, et al. Geographical environment factors and risk mapping of human cystic echinococcosis in western China[J]. Int J Environ Res Public Health, 2018, 15(8): 1729. DOI: 10.3390/ijerph15081729.
    [3]
    LIU J, LIANG W, JING W, et al. Countdown to 2030: Eliminating hepatitis B disease, China[J]. Bull World Health Organ, 2019, 97(3): 230-238. DOI: 10.2471/BLT.18.219469.
    [4]
    CHEN YS, LI L, CUI FQ, et al. A sero-epidemiological study on hepatitis C in China[J]. Chin J Epidemiol, 2011, 32(9): 888-891. DOI: 10.3760/cma.j.issn.0254-6450.2011.09.009.

    陈园生, 李黎, 崔富强, 等. 中国丙型肝炎血清流行病学研究[J]. 中华流行病学杂志, 2011, 32(9): 888-891. DOI: 10.3760/cma.j.issn.0254-6450.2011.09.009.
    [5]
    MYSORE KR, LEUNG DH. Hepatitis B and C[J]. Clin Liver Dis, 2018, 22(4): 703-722. DOI: 10.1016/j.cld.2018.06.002.
    [6]
    ZHENG X, LIU J, WU J, et al. Advances and challenges in immune control and functional cure of chronic hepatitis B[J]. J Clin Hepatol, 2020, 36(5): 961-964. DOI: 10.3969/j.issn.1001-5256.2020.05.001.

    郑昕, 刘嘉, 吴珺, 等. 免疫控制与慢性乙型肝炎功能性治愈的进展与挑战[J]. 临床肝胆病杂志, 2020, 36(5): 961-964. DOI: 10.3969/j.issn.1001-5256.2020.05.001.
    [7]
    CHEN C, GAO Q, LUO Y, et al. The immunotherapy with hMASP-2 DNA nanolipoplexes against echinococcosis in experimentally protoscolex-infected mice[J]. Acta Trop, 2020, 210: 105579. DOI: 10.1016/j.actatropica.2020.105579.
    [8]
    WANG ZY, LIU YH, ZHANG R, et al. Epidemiological characteristics of hepatitis B in China from 2004 to 2013[J]. Chin Gen Pract, 2017, 20(23): 2879-2883. DOI: 10.3969/j.issn.1007-9572.

    王祖煜, 刘熠赫, 张芮, 等. 2004-2013年中国乙型病毒性肝炎的流行病学特征研究[J]. 中国全科医学, 2017, 20(23): 2879-2883. DOI: 10.3969/j.issn.1007-9572.
    [9]
    Ministry of Health, The People's Republic of China. Diagnostic Criteria For Echinococcosis(WS257-2006)[S]. Beijing: People's Medical Publishing House, 2006.

    中华人民共和国卫生部. 包虫病诊断标准(WS257-2006)[S]. 北京: 人民卫生出版社, 2006.
    [10]
    Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association. The guideline of prevention and treatment for chronic hepatitis B: A 2015 update[J]. J Clin Hepatol, 2015, 31(12): 1941-1960. DOI: 10.3969/j.issn.1001-5256.2015.12.002.

    中华医学会肝病学分会, 中华医学会感染病学分会. 慢性乙型肝炎防治指南(2015年更新版)[J]. 临床肝胆病杂志, 2015, 31(12): 1941-1960. DOI: 10.3969/j.issn.1001-5256.2015.12.002.
    [11]
    Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association. The guideline of prevention and treatment for hepatitis C: A 2015 update[J]. J Clin Hepatol, 2015, 31(12): 1961-1979. DOI: 10.3969/j.issn.1001-5256.2015.12.003.

    中华医学会肝病学分会, 中华医学会感染病学分会. 丙型肝炎防治指南(2015年更新版)[J]. 临床肝胆病杂志, 2015, 31(12): 1961-1979. DOI: 10.3969/j.issn.1001-5256.2015.12.003.
    [12]
    Chinese Society of Hepatology, Chinese Medical Association. Chinese guidelines on the management of liver cirrhosis[J]. J Clin Hepatol, 2019, 35(11): 2408-2425. DOI: 10.3969/j.issn.1001-5256.2019.11.006.

    中华医学会肝病学分会. 肝硬化诊治指南[J]. 临床肝胆病杂志, 2019, 35(11): 2408-2425. DOI: 10.3969/j.issn.1001-5256.2019.11.006.
    [13]
    National Health and Family Planning Commission of the People's Republic of China. Diagnosis, management, and treatment of hepatocellular carcinoma (V2017)[J]. J Clin Hepatol, 2017, 33(8): 1419-1431. DOI: 10.3969/j.issn.1001-5256.2017.08.003.

    中华人民共和国国家卫生和计划生育委员会. 原发性肝癌诊疗规范(2017年版)[J]. 临床肝胆病杂志, 2017, 33(8): 1419-1431. DOI: 10.3969/j.issn.1001-5256.2017.08.003.
    [14]
    SOLOMON N, KACHANI M, ZEYHLE E, et al. The natural history of cystic echinococcosis in untreated and albendazole-treated patients[J]. Acta Trop, 2017, 171: 52-57. DOI: 10.1016/j.actatropica.2017.03.018.
    [15]
    Chinese Society of Hepatology, Chinese Medical Association. Strengthen prevention of chronic hepatitis B blocking liver cirrhosis and liver cancer[J]. Health Guide, 2020, 7: 14-15.

    中华医学会肝病学分会. 加强预防慢性乙肝阻截肝硬化和肝癌[J]. 健康指南, 2020, 7: 14-15.
    [16]
    LEVRERO M, ZUCMAN-ROSSI J. Mechanisms of HBV-induced hepatocellular carcinoma[J]. J Hepatol, 2016, 64(1 Suppl): S84, S101. DOI: 10.1016/j.jhep.2016.02.021.
    [17]
    GAO P, LUO YP, LI JF. Effects of hepatitis B virus on T lymphocytes and their subsets in chronic hepatitis B patients in different ALT states[J]. J Jilin Univ(Med Edit), 2020, 46(2): 359-364. DOI: 10.13481/j.1671-587x.20200225.

    高鹏, 雒艳萍, 李俊峰. 乙型肝炎病毒对不同ALT状态下慢性乙型肝炎患者T淋巴细胞及其亚群的影响[J]. 吉林大学学报(医学版), 2020, 46(2): 359-364. DOI: 10.13481/j.1671-587x.20200225.
    [18]
    ZHANG WL, LIU ZJ, GAN HZ, et al. Effect of viral load on serum inflammatory factors, immune function indexes and liver function indexes in patients with hepatitis B virus infection[J]. Clin J Med Offic, 2020, 48(7): 856-857. DOI: 10.16680/j.1671-3826.2020.07.44.

    张文良, 刘正金, 甘海忠, 等. 乙型肝炎病毒感染患者病毒载量对血清炎症因子、免疫功能指标及肝功能指标影响[J]. 临床军医杂志, 2020, 48(7): 856-857. DOI: 10.16680/j.1671-3826.2020.07.44.
    [19]
    SAXENA R, KAUR J. Th1/Th2 cytokines and their genotypes as predictors of hepatitis B virus related hepatocellular carcinoma[J]. World J Hepatol, 2015, 7(11): 1572-1580. DOI: 10.4254/wjh.v7.i11.1572.
    [20]
    LI H, ZHENG HW, CHEN H, et al. Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines[J]. Dig Liver Dis, 2012, 44(4): 328-333. DOI: 10.1016/j.dld.2011.11.005.
    [21]
    LI TY, YANG Y, ZHOU G, et al. Immune suppression in chronic hepatitis B infection associated liver disease: A review[J]. World J Gastroenterol, 2019, 25(27): 3527-3537. DOI: 10.3748/wjg.v25.i27.3527.
    [22]
    DÍAZ Á. Immunology of cystic echinococcosis (hydatid disease)[J]. Br Med Bull, 2017, 124(1): 121-133. DOI: 10.1093/bmb/ldx033.
    [23]
    BERRIEL E, FREIRE T, CHIALE C, et al. Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1+ cell activation in mice[J]. Cancer Immunol Immun, 2021, 70: 3617-3627. DOI: 10.1007/s00262-021-02948-x.
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