Multi-omics molecular subgrouping of hepatocellular carcinoma and its application in precision diagnosis and treatment

Liangqing DONG; Qiang GAO

doi:10.3969/j.issn.1001-5256.2022.03.004

Volume 38 Issue 3

Mar. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(3): 510-514

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Multi-omics molecular subgrouping of hepatocellular carcinoma and its application in precision diagnosis and treatment

DOI: 10.3969/j.issn.1001-5256.2022.03.004

Liangqing DONG,
Qiang GAO^{,
,}

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China

Research funding:

National Natural Science Foundation of China (81961128025);

National Natural Science Foundation of China (82002514);

Science and Technology Commission of Shanghai Municipality (19XD1420700)

More Information

Corresponding author: GAO Qiang, gaoqiang@fudan.edu.cn(ORCID: 0000-0002-6695-9906)
Received Date: 2022-02-15
Accepted Date: 2022-02-17
Published Date: 2022-03-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality in China. In recent years, the application of targeted therapy and immunotherapy has improved the survival rate of HCC patients. However, a significant difference in treatment response is observed among HCC patients due to tumor heterogeneity and a lack of biomarkers to predict efficacy. The advance in proteogenomics-centered multi-omics studies and the development of high-throughput drug screening platforms will help to develop new clinical treatment strategies for HCC and new methods for predicting the efficacy of precision medication, thereby realizing personalized precision diagnosis and treatment.
- Carcinoma, Hepatocellular,
- Genetic Heterogeneity,
- Drug Screening Assays, Antitumor,
- Therapeutics

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References(106)

References

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Multi-omics molecular subgrouping of hepatocellular carcinoma and its application in precision diagnosis and treatment

DOI: 10.3969/j.issn.1001-5256.2022.03.004

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Multi-omics molecular subgrouping of hepatocellular carcinoma and its application in precision diagnosis and treatment

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