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CN 22-1108/R
Volume 38 Issue 1
Jan.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(1): 224-227

Research advances in the mechanism of action of TRPV4 ion channel protein in liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.01.040

  • Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China

Research funding:

The Key Project of Hubei Province (2020BCB007)

  • Received Date: 2021-05-30
  • Accepted Date: 2021-07-12
  • Published Date: 2022-01-20
    Abstract
  • As a member of the transient receptor potential ion channel family, transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel and is widely distributed in a variety of tissues and organs. In recent years, more and more studies have shown that TRPV4 channel proteins are closely associated with liver diseases such as liver fibrosis, liver cancer, and polycystic liver disease. This article analyzes the articles on TRPV4 and liver disease and summarizes the exact signaling pathways and possible potential mechanism between TRPV4 and liver disease, so as to provide new ideas for clinical application and further studies.

     

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