Research advances in adverse liver reactions caused by immune checkpoint inhibitors

Yu WANG; Zhaoying LI; Shuang LI; Chenghai LIU

doi:10.3969/j.issn.1001-5256.2022.01.039

Volume 38 Issue 1

Jan. 2022

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Research advances in adverse liver reactions caused by immune checkpoint inhibitors

DOI: 10.3969/j.issn.1001-5256.2022.01.039

Yu WANG¹,
Zhaoying LI²,
Shuang LI¹,
Chenghai LIU^{3a, 3b
,
,}

1.
Department of Gastroenterology, Baoshan Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 201999, China
2.
Department of Neurology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610000, China
3a.
Second Department of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3b.
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Research funding:

Key specialty construction of Shanghai Baoshan District Health and Family Planning Commission (BSK-2018-A03);

Shanghai Municipal Health Commission Research project plan (20214Y0236)

Received Date: 2021-06-07
Accepted Date: 2021-06-28
Published Date: 2022-01-20

Abstract

Abstract

Immune checkpoint inhibitors can enhance the anti-tumor effect of T cells by blocking the negative regulatory signal of T cells, and meanwhile, they may also cause the imbalance of immune tolerance or normal immune hyperfunction, thus leading to immune hepatitis. This article mainly reviews the therapeutic mechanism of immune checkpoint inhibitors, their mechanism in causing the adverse reaction of liver injury, related risk factors, and incidence rate and summarizes the treatment methods for liver injury caused by immune checkpoint inhibitors. It is believed that while promoting anti-tumor immunity, immune checkpoint inhibitors may cause non-homogeneous immune-related liver injury due to the specificity of non-tumor tissue targets, and the main purpose of treatment is to restore immune homeostasis. Therefore, the management of patients using immune checkpoint inhibitors often requires a balance between treatment window, toxicity, and treatment of specific injury, as well as multidisciplinary collaboration.
- Chemical and Drug Induced Liver Injury,
- Immunosuppressive Agents,
- Therapeutics

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References

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Research advances in adverse liver reactions caused by immune checkpoint inhibitors

DOI: 10.3969/j.issn.1001-5256.2022.01.039

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