中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 12
Dec.  2021
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(12): 2981-2985

Research advances in intraductal papillary mucinous neoplasm of the bile tract

DOI: 10.3969/j.issn.1001-5256.2021.12.052

  • Department of Gastroenterology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China

Research funding:

Science and Technology Foundation Project of Guizhou Province (J LKZ〔2013〕13 of Guizhou Science and Technology Cooperation)

  • Received Date: 2021-05-25
  • Accepted Date: 2021-07-01
  • Published Date: 2021-12-20
    Abstract
  • Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is a special type of tumor occurring in the biliary system, with no specific clinical manifestations and imaging findings, and thus it is difficult to diagnose before surgery. It is often considered when a large amount of mucus is found in the bile duct during surgery and then it is forced to change the surgical plan. Clinicians lack an understanding of this disease due to its low incidence rate. This article reviews the recent research advances in the etiology and classification, clinical features, differential diagnosis, treatment, and prognosis of IPMN-B, so as to improve the clinical diagnosis and treatment of IPMN-B among clinicians.

     

    • FullText(HTML)
  • loading
    • References(34)
  • [1]
    KIM HJ, KIM MH, LEE SK, et al. Mucin-hypersecreting bile duct tumor characterized by a striking homology with an intraductal papillary mucinous tumor (IPMT) of the pancreas[J]. Endoscopy, 2000, 32(5): 389-393. DOI: 10.1055/s-2000-8996.
    [2]
    PARK HJ, KIM SY, KIM HJ, et al. Intraductal papillary neoplasm of the bile duct: Clinical, imaging, and pathologic features[J]. AJR Am J Roentgenol, 2018, 211(1): 67-75. DOI: 10.2214/AJR.17.19261.
    [3]
    PAIK KY, HEO JS, CHOI SH, et al. Intraductal papillary neoplasm of the bile ducts: The clinical features and surgical outcome of 25 cases[J]. J Surg Oncol, 2008, 97(6): 508-512. DOI: 10.1002/jso.20994.
    [4]
    CAI HQ, GENG ZM. Research progress of intradutal papillary neoplasm of the bile duct[J]. Chin J Dig Surg, 2017, 16(8): 879-882. DOI: 10.3760/cma.j.issn.1673-9752.2017.08.024.

    蔡慧强, 耿智敏. 胆管内乳头状肿瘤的研究进展[J]. 中华消化外科杂志, 2017, 16(8): 879-882. DOI: 10.3760/cma.j.issn.1673-9752.2017.08.024.
    [5]
    ZACCARI P, CARDINALE V, SEVERI C, et al. Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas[J]. World J Gastroenterol, 2019, 25(31): 4343-4359. DOI: 10.3748/wjg.v25.i31.4343.
    [6]
    VALENTE R, CAPURSO G, PIERANTOGNETTI P, et al. Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy[J]. World J Gastrointest Oncol, 2012, 4(2): 22-25. DOI: 10.4251/wjgo.v4.i2.22.
    [7]
    WU XR, ZHAO S, MIAO L, et al. A case report of mucinous papillary adenocarcinoma of extrahepatic bile duct with colloid carcinoma infiltration and recurrent choledocholithiasis[J]. Chin J Dig Endosc, 2020, 37(10): 757-758. DOI: 10.3760/cma.j.cn321463-20190528-00378.

    巫雪茹, 赵思, 缪林, 等. 肝外胆管黏液性乳头状腺癌伴胶样癌浸润合并复发性胆总管结石一例[J]. 中华消化内镜杂志, 2020, 37(10): 757-758. DOI: 10.3760/cma.j.cn321463-20190528-00378.
    [8]
    ROCHA FG, LEE H, KATABI N, et al. Intraductal papillary neoplasm of the bile duct: A biliary equivalent to intraductal papillary mucinous neoplasm of the pancreas?[J]. Hepatology, 2012, 56(4): 1352-1360. DOI: 10.1002/hep.25786.
    [9]
    WANG X, CAI YQ, CHEN YH, et al. Biliary tract intraductal papillary mucinous neoplasm: Report of 19 cases[J]. World J Gastroenterol, 2015, 21(14): 4261-4267. DOI: 10.3748/wjg.v21.i14.4261.
    [10]
    WANG SD, WANG XW, LIU GH, et al. Research advances in intradutal papillary neoplasm of the bile duct[J]. J Clin Hepatol, 2020, 36(2): 476-480. DOI: 10.3969/j.issn.1001-5256.2020.02.054.

    王士东, 王小玮, 刘国红, 等. 胆管内乳头状肿瘤的研究现状[J]. 临床肝胆病杂志, 2020, 36(2): 476-480. DOI: 10.3969/j.issn.1001-5256.2020.02.054.
    [11]
    WHITE AD, YOUNG AL, VERBEKE C, et al. Biliary papillomatosis in three Caucasian patients in a Western centre[J]. Eur J Surg Oncol, 2012, 38(2): 181-184. DOI: 10.1016/j.ejso.2011.11.007.
    [12]
    YANG X, ZHOU X, HU CY, et al. Intraductal papillary neoplasm of intrahepatic bile duct: One case report[J]. Chin J Gastroenterol and Hepatol, 2020, 29(12): 1383-1385. DOI: 10.3969/j.issn.1006-5709.2020.12.013.

    杨潇, 周晓, 胡春阳, 等. 肝内胆管导管内乳头状肿瘤1例报道[J]. 胃肠病学和肝病学杂, 2020, 29(12): 1383-1385. DOI: 10.3969/j.issn.1006-5709.2020.12.013.
    [13]
    BENNETT S, MARGINEAN EC, PAQUIN-GOBEIL M, et al. Clinical and pathological features of intraductal papillary neoplasm of the biliary tract and gallbladder[J]. HPB (Oxford), 2015, 17(9): 811-818. DOI: 10.1111/hpb.12460.
    [14]
    OHTSUKA M, KIMURA F, SHIMIZU H, et al. Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion[J]. Am J Surg Pathol, 2011, 35(4): 512-521. DOI: 10.1097/PAS.0b013e3182103f36.
    [15]
    KIM KM, LEE JK, SHIN JU, et al. Clinicopathologic features of intraductal papillary neoplasm of the bile duct according to histologic subtype[J]. Am J Gastroenterol, 2012, 107(1): 118-125. DOI: 10.1038/ajg.2011.316.
    [16]
    LI RR, CHEN YY, ZHOU S. A case report of papillary mucinous tumor in bile duct[J/CD]. Chin J Hepat Surg: Electronic Edition, 2020, 9(6): 609-612. DOI: 10.3877/cma.j.issn.2095-3232.2020.06.023.

    李冉冉, 陈永艺, 周松. 胆管内乳头状黏液性肿瘤一例[J/CD]. 中华肝脏外科手术学电子杂志, 2020, 9(6): 609-612. DOI: 10.3877/cma.j.issn.2095-3232.2020.06.023.
    [17]
    RUIZ A, VEDEL B, FABRE C, et al. Intraductal papillary mucinous neoplasm of the bile ducts (IPMN-B)[J]. Clin Res Hepatol Gastroenterol, 2016, 40(4): 370-372. DOI: 10.1016/j.clinre.2016.03.001.
    [18]
    WANG M, DENG BY, WEN TF, et al. An observational and comparative study on intraductal papillary mucinous neoplasm of the biliary tract and the pancreas from a Chinese cohort[J]. Clin Res Hepatol Gastroenterol, 2016, 40(2): 161-168. DOI: 10.1016/j.clinre.2015.12.002.
    [19]
    LI LT, WU B, WANG SQ, et al. Intrahepatic biliary papillomatosis with local canceration: A case report[J]. J Clin Hepatol, 2018, 34(8): 1760-1762. DOI: 10.3969/j.issn.1001-5256.2018.08.035.

    李良涛, 武波, 王守乾, 等. 肝内胆管乳头状瘤伴局部癌变1例报告[J]. 临床肝胆病杂志, 2018, 34(8): 1760-1762. DOI: 10.3969/j.issn.1001-5256.2018.08.035.
    [20]
    ZHANG H, ZHONG Z, KONG G, et al. Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts[J]. PeerJ, 2020, 8: e10040. DOI: 10.7717/peerj.10040.
    [21]
    OHTSUKA M, SHIMIZU H, KATO A, et al. Intraductal papillary neoplasms of the bile duct[J]. Int J Hepatol, 2014, 2014: 459091. DOI: 10.1155/2014/459091.
    [22]
    YING S, YING M, LIANG W, et al. Morphological classification of intraductal papillary neoplasm of the bile duct[J]. Eur Radiol, 2018, 28(4): 1568-1578. DOI: 10.1007/s00330-017-5123-2.
    [23]
    LIU LN, XU HX, ZHANG YF, et al. Imaging features of intraductal papillary neoplasm of the bile duct (IPN-B) on baseline ultrasound and contrast-enhanced ultrasound[J]. Chin J Ultrasonogr, 2012, 21(11): 969-972. DOI: 10.3760/cma.j.issn.1004-4477.2012.11.016.

    刘琳娜, 徐辉雄, 张一峰, 等. 胆管内乳头状肿瘤超声及超声造影表现[J]. 中华超声影像学杂志, 2012, 21(11): 969-972. DOI: 10.3760/cma.j.issn.1004-4477.2012.11.016.
    [24]
    LIU YB, LI M, ZHONG XM, et al. Imaging features of intraductal papillary neoplasm of the bile duct[J]. Chin J Radiol, 2014, 48(2): 128-131. DOI: 10.3760/cma.j.issn.1005-1201.2014.02.010.

    刘于宝, 李萌, 钟小梅, 等. 胆管导管内乳头状肿瘤的影像表现[J]. 中华放射学杂志, 2014, 48(2): 128-131. DOI: 10.3760/cma.j.issn.1005-1201.2014.02.010.
    [25]
    YING SH, ZHAO YL, TENG XD, et al. Imaging findings and morphology classification of intreductal papillary mucinous neoplasm of the bile duct[J]. Chin J Radiol, 2015, 49(1): 42-46. DOI: 10.3760/cma.j.issn.1005-1201.2015.01.011.

    应世红, 赵艺蕾, 滕晓东, 等. 胆管导管内乳头状黏液性肿瘤的影像表现和形态分型[J]. 中华放射学杂志, 2015, 49(1): 42-46. DOI: 10.3760/cma.j.issn.1005-1201.2015.01.011.
    [26]
    YOON HJ, KIM YK, JANG KT, et al. Intraductal papillary neoplasm of the bile ducts: Description of MRI and added value of diffusion-weighted MRI[J]. Abdom Imaging, 2013, 38(5): 1082-1090. DOI: 10.1007/s00261-013-9989-4.
    [27]
    YING SH, TENG XD, WANG ZM, et al. Gd-EOB-DTPA-enhanced magnetic resonance imaging for bile duct intraductal papillary mucinous neoplasms[J]. World J Gastroenterol, 2015, 21(25): 7824-7833. DOI: 10.3748/wjg.v21.i25.7824.
    [28]
    REN X, ZHU CL, QIN XF, et al. Co-occurrence of IPMN and malignant IPNB complicated by a pancreatobiliary fistula: A case report and review of the literature[J]. World J Clin Cases, 2019, 7(1): 102-108. DOI: 10.12998/wjcc.v7.i1.102.
    [29]
    PAN P, ZHAO SB, WANG S, et al. Biliary dilatation in a 67-year-old woman: Seeing is believing[J]. Gut, 2020, 69(2): 223-310. DOI: 10.1136/gutjnl-2018-318200.
    [30]
    KUBOTA K, NAKANUMA Y, KONDO F, et al. Clinicopathological features and prognosis of mucin-producing bile duct tumor and mucinous cystic tumor of the liver: A multi-institutional study by the Japan Biliary Association[J]. J Hepatobiliary Pancreat Sci, 2014, 21(3): 176-185. DOI: 10.1002/jhbp.23.
    [31]
    WU X, LI BL, ZHENG CJ, et al. Diagnosis and surgical treatment of intraductal papillary mucinous of biliary tract[J]. Chin J Hepatobiliary Surg, 2017, 23(1): 28-31. DOI: 10.3760/cma.j.issn.1007-8118.2017.01.009.

    吴昕, 李秉璐, 郑朝纪, 等. 胆管导管内乳头状黏液瘤的诊断和外科治疗[J]. 中华肝胆外科杂志, 2017, 23(1): 28-31. DOI: 10.3760/cma.j.issn.1007-8118.2017.01.009.
    [32]
    RIZZO A, FREGA G, RICCI AD, et al. Anti-EGFR monoclonal antibodies in advanced biliary tract cancer: A systematic review and meta-analysis[J]. In Vivo, 2020, 34(2): 479-488. DOI: 10.21873/invivo.11798.
    [33]
    LEVY MJ, WONG KEE SONG LM, KENDRICK ML, et al. EUS-guided coil embolization for refractory ectopic variceal bleeding (with videos)[J]. Gastrointest Endosc, 2008, 67(3): 572-574. DOI: 10.1016/j.gie.2007.06.063.
    [34]
    GUO W, ZHANG ZT. Diagnosis and treatment of intraductal papillary neoplasm of the bile duct[J]. Chin J Dig Surg, 2018, 17(3): 233-236. DOI: 10.3760/cma.j.issn.1673-9752.2018.03.005.

    郭伟, 张忠涛. 胆管内乳头状肿瘤的诊断与治疗[J]. 中华消化外科杂志, 2018, 17(3): 233-236. DOI: 10.3760/cma.j.issn.1673-9752.2018.03.005.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1070) PDF downloads(92) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return