| [1] |
HUANG H, WENG H, SUN W, et al. Recognition of RNA N(6)- methyladenosine by IGF2BP proteins enhances mRNA stability and translation[J]. Nat Cell Biol, 2018, 20(3): 285-295. DOI: 10.1038/s41556-018-0045-z. |
| [2] |
ZHAO BS, WANG X, BEADELL AV, et al. m(6)A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition[J]. Nature, 2017, 542(7642): 475-478. DOI: 10.1038/nature21355. |
| [3] |
LIU Z, ZHANG J. Human C-to-U coding RNA editing is largely nonadaptive[J]. Mol Biol Evol, 2018, 35(4): 963-969. DOI: 10.1093/molbev/msy011. |
| [4] |
PING XL, SUN BF, WANG L, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase[J]. Cell Res, 2014, 24(2): 177-189. DOI: 10.1038/cr.2014.3. |
| [5] |
JIA G, FU Y, ZHAO X, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO[J]. Nat Chem Biol, 2011, 7(12): 885-887. DOI: 10.1038/nchembio.687. |
| [6] |
FU Y, JIA G, PANG X, et al. FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA[J]. Nat Commun, 2013, 4: 1798. DOI: 10.1038/ncomms2822. |
| [7] |
SHI H, WANG X, LU Z, et al. YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA[J]. Cell Res, 2017, 27(3): 315-328. DOI: 10.1038/cr.2017.15. |
| [8] |
HE S, WANG H, LIU R, et al. mRNA N6-methyladenosine methylation of postnatal liver development in pig[J]. PLoS One, 2017, 12(3): e0173421. DOI: 10.1371/journal.pone.0173421. |
| [9] |
NAKANO M, ONDO K, TAKEMOTO S, et al. Methylation of adenosine at the N(6) position post-transcriptionally regulates hepatic P450s expression[J]. Biochem Pharmacol, 2020, 171: 113697. DOI: 10.1016/j.bcp.2019.113697. |
| [10] |
JABS S, BITON A, BÉCAVIN C, et al. Impact of the gut microbiota on the m(6)A epitranscriptome of mouse cecum and liver[J]. Nat Commun, 2020, 11(1): 1344. DOI: 10.1038/s41467-020-15126-x. |
| [11] |
FUSTIN JM, DOIM, YAMAGUCHI Y, et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock[J]. Cell, 2013, 155(4): 793-806. DOI: 10.1016/j.cell.2013.10.026. |
| [12] |
IMAM H, KHAN M, GOKHALE NS, et al. N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle[J]. Proc Natl Acad Sci U S A, 2018, 115(35): 8829-8834. DOI: 10.1073/pnas.1808319115. |
| [13] |
KIM GW, SIDDIQUI A. Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs[J]. Proc Natl Acad Sci U S A, 2021, 118(3). DOI: 10.1073/pnas.2019455118. |
| [14] |
GOKHALE NS, MCINTYRE A, MCFADDEN MJ, et al. N6-methyladenosine in flaviviridae viral RNA genomes regulates infection[J]. Cell Host Microbe, 2016, 20(5): 654-665. DOI: 10.1016/j.chom.2016.09.015. |
| [15] |
DURBIN AF, WANG C, MARCOTRIGIANO J, et al. RNAs containing modified nucleotides fail to trigger RIG-I conformational changes for innate immune signaling[J]. mBio, 2016, 7(5). DOI: 10.1128/mBio.00833-16. |
| [16] |
GOKHALE NS, MCINTYRE A, MATTOCKS MD, et al. Altered m(6)A modification of specific cellular transcripts affects flaviviridae infection[J]. Mol Cell, 2020, 77(3): 542-555. e8. DOI: 10.1016/j.molcel.2019.11.007. |
| [17] |
RAO X, LAI L, LI X, et al. N(6) -methyladenosine modification of circular RNA circ-ARL3 facilitates hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305[J]. IUBMB Life, 2021, 73(2): 408-417. DOI: 10.1002/iub.2438. |
| [18] |
KIM GW, SIDDIQUI A. N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition[J]. Proc Natl Acad Sci U S A, 2021, 118(10): e2022024118. DOI: 10.1073/pnas.2022024118. |
| [19] |
KLEINER DE, BRUNT EM, VAN NATTA M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease[J]. Hepatology, 2005, 41(6): 1313-1321. DOI: 10.1002/hep.20701. |
| [20] |
CHEN X, LUO Y, JIA G, et al. FTO promotes adipogenesis through inhibition of the Wnt/β-catenin signaling pathway in porcine intramuscular preadipocytes[J]. Anim Biotechnol, 2017, 28(4): 268-274. DOI: 10.1080/10495398.2016.1273835. |
| [21] |
KANG H, ZHANG Z, YU L, et al. FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation[J]. J Cell Biochem, 2018, 119(7): 5676-5685. DOI: 10.1002/jcb.26746. |
| [22] |
MERKESTEIN M, LABER S, MCMURRAY F, et al. FTO influences adipogenesis by regulating mitotic clonal expansion[J]. Nat Commun, 2015, 6: 6792. DOI: 10.1038/ncomms7792. |
| [23] |
WU R, LIU Y, YAO Y, et al. FTO regulates adipogenesis by controlling cell cycle progression via m(6)A-YTHDF2 dependent mechanism[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(10): 1323-1330. DOI: 10.1016/j.bbalip.2018.08.008. |
| [24] |
WANG X, ZHU L, CHEN J, et al. mRNA m 6A methylation downregulates adipogenesis in porcine adipocytes[J]. Biochem Biophys Res Commun, 2015, 459(2): 201-207. DOI: 10.1016/j.bbrc.2015.02.048. |
| [25] |
XIE W, MA LL, XU YQ, et al. METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism[J]. Biochem Biophys Res Commun, 2019, 518(1): 120-126. DOI: 10.1016/j.bbrc.2019.08.018. |
| [26] |
CHEN J, ZHOU X, WU W, et al. FTO-dependent function of N6- methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice[J]. J Physiol Biochem, 2015, 71(3): 405-413. DOI: 10.1007/s13105-015-0420-1. |
| [27] |
ZHOU X, CHEN J, CHEN J, et al. The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit[J]. J Nutr Biochem, 2015, 26(12): 1678-1684. DOI: 10.1016/j.jnutbio.2015.08.014. |
| [28] |
LU N, LI X, YU J, et al. Curcumin attenuates lipopolysaccharide-induced hepatic lipid metabolism disorder by modification of m(6)A RNA methylation in piglets[J]. Lipids, 2018, 53(1): 53-63. DOI: 10.1002/lipd.12023. |
| [29] |
LIU XY, LIU RX, HOU F, et al. Fibronectin expression is critical for liver fibrogenesis in vivo and inïvitro[J]. Mol Med Rep, 2016, 14(4): 3669-3675. DOI: 10.3892/mmr.2016.5673. |
| [30] |
CUI Z, HUANG N, LIU L, et al. Dynamic analysis of m6A methylation spectroscopy during progression and reversal of hepatic fibrosis[J]. Epigenomics, 2020, 12(19): 1707-1723. DOI: 10.2217/epi-2019-0365. |
| [31] |
ZHU Y, PAN X, DU N, et al. ASIC1a regulates miR-350/SPRY2 by N(6) -methyladenosine to promote liver fibrosis[J]. FASEB J, 2020, 34(11): 14371-14388. DOI: 10.1096/fj.202001337R. |
| [32] |
BRAY F, FERLAY J, SOERJOMATARAM I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424. DOI: 10.3322/caac.21492. |
| [33] |
CHEN M, WEI L, LAW CT, et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2[J]. Hepatology, 2018, 67(6): 2254-2270. DOI: 10.1002/hep.29683. |
| [34] |
MA JZ, YANG F, ZHOU CC, et al. METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N(6) -methyladenosine-dependent primary MicroRNA processing[J]. Hepatology, 2017, 65(2): 529-543. DOI: 10.1002/hep.28885. |
| [35] |
YANG Z, LI J, FENG G, et al. MicroRNA-145 modulates N(6)-methyladenosine levels by targeting the 3'-untranslated mRNA region of the N(6)-methyladenosine binding YTH domain family 2 protein[J]. J Biol Chem, 2017, 292(9): 3614- 3623. DOI: 10.1074/jbc.M116.749689. |
| [36] |
LI J, ZHU L, SHI Y, et al. m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation[J]. Am J Transl Res, 2019, 11(9): 6084-6092.
|
| [37] |
CHEN Y, ZHAO Y, CHEN J, et al. ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1[J]. Mol Cancer, 2020, 19(1): 123. DOI: 10.1186/s12943-020-01239-w. |
| [38] |
WU X, ZHANG X, TAO L, et al. Prognostic value of an m6A RNA methylation regulator-based signature in patients with hepatocellular carcinoma[J]. Biomed Res Int, 2020, 2020: 2053902. DOI: 10.1155/2020/2053902. |
| [39] |
LIN Z, NIU Y, WAN A, et al. RNA m(6) A methylation regulates sorafenib resistance in liver cancer through FOXO3-mediated autophagy[J]. EMBO J, 2020, 39(12): e103181. DOI: 10.15252/embj.2019103181. |
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