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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 11
Nov.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(11): 2696-2700

Immunotherapy for acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2021.11.046
  • 1.

    Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China

  • 2.

    Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation Project (81960841);

General Project of National Natural Science Foundation Project (82060848);

Guangxi Natural Science Fund Project (2018GXNSFAA281096);

Guangxi Natural Science Fund Project (2020JJA140273)

  • Received Date: 2021-03-28
  • Accepted Date: 2021-04-21
  • Published Date: 2021-11-20
    Abstract
  • Acute-on-chronic liver failure (ACLF) is a life-threatening disease with a high risk of multiple organ failure, sepsis, and death. ACLF activates innate and acquired immune responses in human body and thus leads to the progression of persistent systemic inflammatory response syndrome and multiple organ dysfunction, leading to the high mortality rate of this disease. Dysregulated immune response plays a key role in disease progression, and immunotherapy may help to target immune-mediated organ damage and inhibit the progression of liver failure. This article reviews the role and mechanism of drugs and means with a potential immune regulatory effect in ACLF, in order to provide a reference for immunotherapy for ACLF.

     

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