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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 6
Jun.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(6): 1278-1278

Antiviral therapy should be selected for patients in the immune-tolerant phase of chronic hepatitis B virus infection

DOI: 10.3969/j.issn.1001-5256.2021.06.010

  • First Department of Liver Disease Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

  • Received Date: 2021-03-28
  • Accepted Date: 2021-05-13
  • Published Date: 2021-06-20
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    • References(6)
  • [1]
    Polaris Observatory Collaborators. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: A modelling study[J]. Lancet Gastroenterol Hepatol, 2018, 3(6): 383-403. DOI: 10.1016/S2468-1253(18)30056-6.
    [2]
    LEE HW, CHAN HL. Unresolved issues of immune tolerance in chronic hepatitis B[J]. J Gastroenterol, 2020, 55(4): 383-389. DOI: 10.1007/s00535-020-01665-z.
    [3]
    CHEN CF, LEE WC, YANG HI, et al. Changes in serum levels of HBV DNA and alanine aminotransferase determine risk for hepatocellular carcinoma[J]. Gastroenterology, 2011, 141(4): 1240-1248, 1248. e1-2. DOI: 10.1053/j.gastro.2011.06.036.
    [4]
    KIM GA, LIM YS, HAN S, et al. High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B[J]. Gut, 2018, 67(5): 945-952. DOI: 10.1136/gutjnl-2017-314904.
    [5]
    CHANG Y, CHOE WH, SINN DH, et al. Nucleos(t)ide analogue treatment for patients with hepatitis B virus (HBV) e antigen-positive chronic HBV genotype C infection: A nationwide, multicenter, retrospective study[J]. J Infect Dis, 2017, 216(11): 1407-1414. DOI: 10.1093/infdis/jix506.
    [6]
    CHEN CJ, YANG HI, SU J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level[J]. JAMA, 2006, 295(1): 65-73. DOI: 10.1001/jama.295.1.65.
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