Application of sofosbuvir in HCV-infected patients with end-stage renal disease undergoing hemodialysis

Zujiang YU; Ye ZHANG; Jianqi LIAN

doi:10.3969/j.issn.1001-5256.2021.05.045

Volume 37 Issue 5

May 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(5): 1193-1196

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Application of sofosbuvir in HCV-infected patients with end-stage renal disease undergoing hemodialysis

DOI: 10.3969/j.issn.1001-5256.2021.05.045

1.
Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
2.
Department of Infectious Diseases, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China

Received Date: 2020-09-30
Accepted Date: 2020-10-30
Published Date: 2021-05-20

Abstract

Abstract

For chronic hepatitis C patents with end-stage renal disease (ESRD) undergoing hemodialysis, most guidelines recommend the use of direct-acting antivirals containing protease inhibitor (PI), yet dialysis patients with severe liver injury are often unable to receive such treatment due to contraindications to PIs. This article briefly introduces the unmet treatment needs in hepatitis C patients with ESRD undergoing dialysis, reviews the data from clinical trials and real-world studies investigating the use of PI-free sofosbuvir (SOF)-based regimens in such patients, and explores the value of SOF-based regimens in the treatment of dialysis patients in China and issues requiring further research. It is pointed out that full-dose SOF-based regimens have good clinical effect, tolerability, and safety in dialysis patients and thus provide additional safe and effective treatment options for such patients with moderate or severe liver injury.
- Hepatitis C,
- Antiviral Agents,
- Nephrosis,
- Renal Dialysis,
- Kidney Failure, Chronic

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References(42)

References

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Application of sofosbuvir in HCV-infected patients with end-stage renal disease undergoing hemodialysis

DOI: 10.3969/j.issn.1001-5256.2021.05.045

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Application of sofosbuvir in HCV-infected patients with end-stage renal disease undergoing hemodialysis

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