Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma

Xuemei DING; Shilun WU; Wenbing SUN

doi:10.3969/j.issn.1001-5256.2021.05.028

Volume 37 Issue 5

May 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(5): 1121-1125

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Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.05.028

1.
Health Examination Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
2.
Department of Hepatobiliary-Pancreatic-Splenic Surgery, West Branch of Chaoyang Hospital, Capital Medical University, Beijing 100043, China

Received Date: 2020-11-02
Accepted Date: 2020-12-03
Published Date: 2021-05-20

Abstract

Abstract

Objective To investigate the value of preoperative microRNA-192 (miR-192) in peripheral blood mononuclear cells (PBMCs) in predicting microvascular invasion (MVI) of solitary hepatocellular carcinoma (HCC). Methods A total of 136 patients with HCC who underwent surgical treatment in Department of Hepatobiliary-Pancreatic-Splenic Surgery, West Branch of Chaoyang Hospital, Capital Medical University, from March 2018 to April 2020 were enrolled and related data were collected. Ultrasound examination was performed and the expression of miR-192 in PBMCs was measured before surgery. According to the presence or absence of MVI after postoperative pathological examination, the patients were divided into MVI group with 41 patients and non-MVI group with 95 patients. The t-test was used for comparison of continuous data between two groups, and the chi-square test was used for comparison of categorical data between two groups. Univariate and multivariate logistic regression analyses were used to analyze the factors that may be associated with MVI, and the receiver operating characteristic (ROC) curve was used to analyze the value of preoperative miR-192 expression in predicting MVI. Results The MVI group had significantly lower preoperative relative expression of miR-192 in PBMCs than the non-MVI group (0.798±0.164 vs 1.086±0.215, t=7.663, P < 0.01). The multivariate logistic regression analysis showed that preoperative miR-192 (odds ratio [OR]=3.999, 95% confidence interval [CI]: 1.585-10.086, P=0.003), nodule type (OR=3.241, 95%CI: 1.154-9.106, P=0.026), and capsule type (OR=2.776, 95%CI: 1.088-7.084, P=0.033) were independent risk factors for MVI in HCC patients. The area under the ROC curve was 0.872 (95%CI: 0.768-0.931), with a sensitivity of 68.38% and a specificity of 70.59% at the optimal cut-off value of 0.858. Conclusion Preoperative miR-192 in PBMCs is closely associated with the development of MVI in patients with solitary HCC. Low preoperative miR-192, multiple nodules, and absence of capsule may increase the risk of MVI. Preoperative miR-192 level has a good value in predicting MVI in patients with solitary HCC.
- Carcinoma, Hepatocellular,
- Microvascularinvasion,
- MicroRNAs,
- Risk Factors

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Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.05.028

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Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma

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