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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 10
Oct.  2020
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Article Contents

Mechanism of action and clinical application of 17β-hydroxysteroid dehydrogenase 13 in alcohol-related liver diseases

DOI: 10.3969/j.issn.1001-5256.2020.10.044
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  • Received Date: 2020-04-22
  • Published Date: 2020-10-20
  • As a new hepatocyte-specific lipid droplet-related protein,17β-hydroxysteroid dehydrogenase 13( HSD17 B13) is involved in hepatocyte lipid synthesis. Recent studies have shown that an insertion-deletion variant of the HSD17 B13 gene is associated with a reduced risk of chronic liver diseases; however,the specific biological function of HSD17 B13 and its involvement in the pathogenesis of liver diseases remain unclear. This article elaborates on the biological function of HSD17 B13,its mechanism of action in alcohol-related liver,and the research advances in clinical application.

     

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