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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 10
Oct.  2020
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Efficacy and safety of lenvatinib for unresectable,advanced hepatocellular carcinoma in a real-world setting

DOI: 10.3969/j.issn.1001-5256.2020.10.021
  • Published Date: 2020-10-20
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  • [1] KUDO M,FINN RS,QIN S,et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma:A randomised phase 3 non-inferiority trial[J]. Lancet,2018,391(10126):1163-1173.
    [2] Guideline Working Committee of Chinese Society of Clinical Oncology. Guidelines of Chinese society of Clinical Oncology(CSCO)hepatocellular carcinoma(2018,Ⅵ)[M]. Beijing:People’s Medical Publishing House(PMPH),2018.(in Chinese)中国临床肿瘤学会指南工作委员会.中国临床肿瘤学会原发性肝癌诊疗指南(2018. V1)[M].北京:人民卫生出版社,2018.
    [3] IKEDA M,OKUSAKA T,MITSUNAGA S,et al. Safety and pharmacokinetics of lenvatinib in patients with advanced hepatocellular carcinoma[J]. Clin Cancer Res,2016,22(6):1385-1394.
    [4] BERTUCCIO P,TURATI F,CARIOLI G,et al. Global trends and predictions in hepatocellular carcinoma mortality[J]. J Hepatol,2017,67(2):302-309.
    [5] OMATA M,CHENG AL,KOKUDO N,et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma:A 2017 update[J]. Hepatol Int,2017,11(4):317-370.
    [6] CHANG QQ,PENG Y,WANG GJ,et al. Clinical research progress of small molecule tyrosine kinase inhibitors as antihepatocell carcinoma agents[J]. Chin J Clin Pharmacol Ther,2019,24(8):948-956.(in Chinese)常青青,彭英,王广基,等.抗肝癌小分子酪氨酸激酶抑制剂的临床研究进展[J].中国临床药理学与治疗学,2019,24(8):948-956.
    [7] OBI S,SATO T,SATO S,et al. The efficacy and safety of lenvatinib for advanced hepatocellular carcinoma in a real-world setting[J]. Hepatol Int,2019,13(2):199-204.
    [8] YU JI,PARK HC. Radiotherapy as valid modality for hepatocellular carcinoma with portal vein tumor thrombosis[J]. World J Gastroenterol,2016,22(30):6851-6863.
    [9] SCHLUMBERGER M,TAHARA M,WIRTH LJ,et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer[J]. N Engl J Med,2015,372(7):621-630.
    [10] IKEDA K,KUDO M,KAWAZOE S,et al. Phase 2 study of lenvatinib in patients with advanced hepatocellular carcinoma[J]. J Gastroenterol,2017,52(4):512-519.
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