中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 9
Sep.  2020
Turn off MathJax
Article Contents

Research advances in Akkermansia muciniphila and liver injury

DOI: 10.3969/j.issn.1001-5256.2020.09.051
Research funding:

 

  • Published Date: 2020-09-20
  • Liver injury caused by viral and non-viral factors is an important stage of chronic liver disease,and the pathogenesis of liver injury is still a research hotspot. With the deepening of the research on gut microbiota,substantial evidence indicates that gut microbiota participates in the development and progression of liver injury,and it has been confirmed that Akkermansia muciniphila( Akk) has a beneficial effect against liver injury. This article summarizes the role and potential mechanism of Akk in immune-mediated liver injury,alcoholic liver disease,and nonalcoholic fatty liver disease. It is believed that Akk may provide new directions and choices for the prevention and treatment of liver injury.

     

  • loading
  • [1] TILG H,CANI PD,MAYER EA. Gut microbiome and liver diseases[J]. Gut,2016,65(12):2035-2044.
    [2] OTTMAN N,HUUSKONEN L,REUNANEN J,et al. Characterization of outer membrane proteome of akkermansia muciniphila reveals sets of novel proteins exposed to the human intestine[J]. Front Microbiol,2016,7:1157.
    [3] DERRIEN M,VAUGHAN EE,PLUGGE CM,et al. Akkermansia muciniphila gen. nov.,sp. nov.,a human intestinal mucin-degrading bacterium[J]. Int J Syst Evol Microbiol,2004,54(Pt 5):1469-1476.
    [4] OUWERKERK JP,van DER ARK K,DAVIDS M,et al. Adaptation of akkermansia muciniphila to the oxic-anoxic interface of the mucus layer[J]. Appl Environ Microbiol,2016,82(23):6983-6993.
    [5] COLLADO MC,DERRIEN M,ISOLAURI E,et al. Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants,adults,and the elderly[J]. Appl Environ Microbiol,2007,73(23):7767-7770.
    [6] CHENG J,RINGEL-KULKA T,HEIKAMP-DE JONG I,et al.Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children[J]. ISME J,2016,10(4):1002-1014.
    [7] BELZER C,de VOS WM. Microbes inside—from diversity to function:The case of Akkermansia[J]. ISME J,2012,6(8):1449-1458.
    [8] DERRIEN M,van BAARLEN P,HOOIVELD G,et al. Modulation of mucosal immune response,tolerance,and proliferation in mice colonized by the mucin-degrader akkermansia muciniphila[J]. Front Microbiol,2011,2:166.
    [9] CANI PD. Human gut microbiome:Hopes,threats and promises[J]. Gut,2018,67(9):1716-1725.
    [10] RIVERA-CHVEZ F,LOPEZ CA,BUMLER AJ. Oxygen as a driver of gut dysbiosis[J]. Free Radic Biol Med,2017,105:93-101.
    [11] ZHANG H,DIBAISE JK,ZUCCOLO A,et al. Human gut microbiota in obesity and after gastric bypass[J]. Proc Natl Acad Sci U S A,2009,106(7):2365-2370.
    [12] PNG CW,LINDN SK,GILSHENAN KS,et al. Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria[J]. Am J Gastroenterol,2010,105(11):2420-2428.
    [13] WANG L,CHRISTOPHERSEN CT,SORICH MJ,et al. Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism[J]. Appl Environ Microbiol,2011,77(18):6718-6721.
    [14] DAO MC,EVERARD A,ARON-WISNEWSKY J,et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity:Relationship with gut microbiome richness and ecology[J]. Gut,2016,65(3):426-436.
    [15] PLOVIER H,EVERARD A,DRUART C,et al. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice[J]. Nat Med,2017,23(1):107-113.
    [16] EVERARD A,BELZER C,GEURTS L,et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity[J]. Proc Natl Acad Sci U S A,2013,110(22):9066-9071.
    [17] LI J,LIN S,VANHOUTTE PM,et al. Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-/-Mice[J]. Circulation,2016,133(24):2434-2446.
    [18] HEYMANN F,HAMESCH K,WEISKIRCHEN R,et al. The concanavalin A model of acute hepatitis in mice[J]. Lab Anim,2015,49(1 Suppl):12-20.
    [19] WANG HX,LIU M,WENG SY,et al. Immune mechanisms of Concanavalin A model of autoimmune hepatitis[J]. World J Gastroenterol,2012,18(2):119-125.
    [20] WU W,LV L,SHI D,et al. Protective effect of akkermansia muciniphila against immune-mediated liver injury in a mouse model[J]. Front Microbiol,2017,8:1804.
    [21] LI J,CHEN K,LI S,et al. Pretreatment with fucoidan from fucus vesiculosus protected against Con A-induced acute liver injury by inhibiting both intrinsic and extrinsic apoptosis[J].PLo S One,2016,11(4):e0152570.
    [22] SONG E,LEE SK,WANG J,et al. RNA interference targeting Fas protects mice from fulminant hepatitis[J]. Nat Med,2003,9(3):347-351.
    [23] ZHENG SJ,WANG P,TSABARY G,et al. Critical roles of TRAIL in hepatic cell death and hepatic inflammation[J]. J Clin Invest,2004,113(1):58-64.
    [24] MALHI H,BARREYRO FJ,ISOMOTO H,et al. Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity[J]. Gut,2007,56(8):1124-1131.
    [25] LUKOVAC S,BELZER C,PELLIS L,et al. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids[J]. m Bio,2014,5(4):e01438-14.
    [26] SHIN NR,LEE JC,LEE HY,et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice[J].Gut,2014,63(5):727-735.
    [27] BAJAJ JS,HEUMAN DM,HYLEMON PB,et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications[J]. J Hepatol,2014,60(5):940-947.
    [28] MARA U',MARGARET L,LETICIA M. Obeticholic acid reduces bacterial translocation and inhibits intestinal inflflammation in cirrhotic rats[J]. J Hepatol,2016,64(5):1049-1057.
    [29] CARIO E,GERKEN G,PODOLSKY DK. Toll-like receptor 2controls mucosal inflammation by regulating epithelial barrier function[J]. Gastroenterology,2007,132(4):1359-1374.
    [30] MUCCIOLI GG,NASLAIN D,BCKHED F,et al. The endocannabinoid system links gut microbiota to adipogenesis[J]. Mol Syst Biol,2010,6:392.
    [31] FUSUNYAN RD,QUINN JJ,FUJIMOTO M,et al. Butyrate switches the pattern of chemokine secretion by intestinal epithelial cells through histone acetylation[J]. Mol Med,1999,5(9):631-640.
    [32] CIARLO E,HEINONEN T,HERDERSCHEE J,et al. Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo[J]. Sci Rep,2016,6:37944.
    [33] GRANDER C,ADOLPH TE,WIESER V,et al. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease[J]. Gut,2018,67(5):891-901.
    [34] TILG H,MOSCHEN AR,SZABO G. Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis[J]. Hepatology,2016,64(3):955-965.
    [35] BASHIARDES S,SHAPIRO H,ROZIN S,et al. Non-alcoholic fatty liver and the gut microbiota[J]. Mol Metab,2016,5(9):782-794.
    [36] KIM S,LEE Y,KIM Y,et al. Akkermansia muciniphila prevents fatty liver disease,decreases serum triglycerides,and maintains gut homeostasis[J]. Appl Environ Microbiol,2020,86(7).
    [37] ASAOKA Y,TERAI S,SAKAIDA I,et al. The expanding role of fish models in understanding non-alcoholic fatty liver disease[J]. Dis Model Mech,2013,6(4):905-914.
    [38] DAI X,WANG B. Role of gut barrier function in the pathogenesis of nonalcoholic fatty liver disease[J]. Gastroenterol Res Pract,2015,2015:287348.
    [39] ARON-WISNEWSKY J,GABORIT B,DUTOUR A,et al. Gut microbiota and non-alcoholic fatty liver disease:New insights[J]. Clin Microbiol Infect,2013,19(4):338-348.
    [40] JACKSON MA,GOODRICH JK,MAXAN ME,et al. Proton pump inhibitors alter the composition of the gut microbiota[J]. Gut,2016,65(5):749-756.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (770) PDF downloads(92) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return