中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 36 Issue 9
Sep.  2020
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Article Contents

Regulatory effect of tumor-associated neutrophils in the development and progression of liver cancer

DOI: 10.3969/j.issn.1001-5256.2020.09.043
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  • Published Date: 2020-09-20
  • The incidence rate of liver cancer keeps increasing in recent years,and this disease has difficulties in early diagnosis,poor treatment outcome,and poor prognosis. This article describes the research advances in tumor-associated neutrophils involved in the regulation of liver tumor microenvironment and points out that they can be used as a new target for the treatment of liver cancer. Combined with tumor-associated macrophages, regulatory T cells, and various cytokines in liver tumor microenvironment, tumor-associated neutrophils can achieve a systemic anti-tumor effect and thus bring hopes to the treatment of liver cancer.

     

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  • [1] AZIZ B,NAZAR T,AKHLAQ S. The frequency of occurrence of hepatocellular carcinoma after direct antiviral therapy in hepatitis C virus patients[J]. Pak J Med Sci,2019,35(1):101-105.
    [2] MIZUNO R,KAWADA K,ITATANI Y,et al. The role of tumor-associated neutrophils in colorectal cancer[J]. Int J Mol Sci,2019,20(3):529-541.
    [3] KIM Y,LEE D,LEE J,et al. Role of tumor-associated neutrophils in regulation of tumor growth in lung cancer development:A mathematical model[J]. PLo S One,2019,14(1):e0211041-e0211053.
    [4] SANO M,IJICHI H,TAKAHASHI R,et al. Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment[J]. Oncogenesis,2019,8(2):8.
    [5] LI S,CONG X,GAO H,et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells[J]. J Exp Clin Cancer Res,2019,38(1):6-17.
    [6] SODA H,OGAWARA D,FUKUDA Y,et al. Dynamics of blood neutrophil-related indices during nivolumab treatment may be associated with response to salvage chemotherapy for nonsmall cell lung cancer:A hypothesis-generating study[J].Thorac Cancer,2019,10(2):341-346.
    [7] WEN ZF,LIU H,GAO R,et al. Tumor cell-released autophagosomes(TRAPs)promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1[J]. J Immunother Cancer,2018,6(1):151-163.
    [8] TRINER D,DEVENPORT SN,RAMAKRISHNAN SK,et al.Neutrophils restrict tumor-associated microbiota to reduce growth and invasion of colon tumors in mice[J]. Gastroenterology,2019,156(5):1467-1482.
    [9] SENGUPTA S,SUBRAMANIAN BC,PARENT CA. Getting TANned:How the tumor microenvironment drives neutrophil recruitment[J]. J Leukoc Biol,2019,105(3):449-462.
    [10] PYLAEVA E,HARATI MD,SPYRA I,et al. NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils[J]. Int J Cancer,2019,144(1):136-149.
    [11] STEENBRUGGE J,BREYNE K,DEMEYERE K,et al. Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer[J]. J Exp Clin Cancer Res,2018,37(1):191.
    [12] MARTIN A,SEIGNEZ C,RACOEUR C,et al. Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment[J]. Oncotarget,2018,9(47):28364-28378.
    [13] MANFROI B,MOREAUX J,RIGHINI C,et al. Tumor-associated neutrophils correlate with poor prognosis in diffuse large B-cell lymphoma patients[J]. Blood Cancer J,2018,8(7):66.
    [14] JANG TJ,KIM SA,KIM MK. Increased number of arginase 1-positive cells in the stroma of carcinomas compared to precursor lesions and nonneoplastic tissues[J]. Pathol Res Pract,2018,214(8):1179-1184.
    [15] SILVA R,DALLARMI LB,ARAUJO A,et al. Immunohistochemical analysis of neutrophils,interleukin-17,matrix metalloproteinase-9,and neoformed vessels in oral squamous cell carcinoma[J]. J Oral Pathol Med,2018,47(9):856-863.
    [16] YAN C,YANG Q,GONG Z. Tumor-associated neutrophils and macrophages promote gender disparity in hepatocellular carcinoma in Zebrafish[J]. Cancer Res,2017,77(6):1395-1407.
    [17] ZHOU SL,ZHOU ZJ,HU ZQ,et al. tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to Sorafenib[J]. Gastroenterology,2016,150(7):1646-1658.
    [18] ALBINI A,BRUNO A,NOONAN DM,et al. Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment:Implications for immunotherapy[J]. Front Immunol,2018,9(7):527-541.
    [19] XIAO WM,XU SL,LIU JJ,et al. Clinical significance of preoperative neutrophil-to-lymphocyte ratio in prognostic evaluation of patients with hepatocellular carcinoma[J]. Med Equip,2018,31(24):51-52.(in Chinese)肖维木,徐绍良,刘菁菁,等.术前中性粒细胞与淋巴细胞比值对肝癌患者预后评估的临床意义[J].医疗装备,2018,31(24):51-52.
    [20] HE ZB,LIN XJ. Correlation of neutrophils to lymphocyte ratio and platelet to lymphocyte ratio with prognosis of hepatocellular carcinoma patients treated with transarterial chemoembolization[J]. Chin J Clin Oncol,2017,44(6):283-288.(in Chinese)何朝滨,林小军.中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与TACE治疗肝癌患者后的相关性[J].中国肿瘤临床,2017,44(6):283-288.
    [21] DENG GR,CHEN BY,LI R,et al. Clinical impact of preoperative platelet-lymphocyte ratio on prognosis for hepatocellular carcinoma[J/CD]. Chin Arch Gen Surg(Electronic Edition),2017,11(1):13-17.(in Chinese)邓国荣,陈博艺,李荣,等.术前血小板淋巴细胞比率对肝细胞癌患者的临床意义分析[J/CD].中华普通外科学文献(电子版),2017,11(1):13-17.
    [22] WANG Y,PENG C,CHENG Z,et al. The prognostic significance of preoperative neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma receiving hepatectomy:A systematic review and meta-analysis[J]. Int J Surg,2018,55(12):73-80.
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